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Glycoprotein VI (Platelet) Proteins (GP6)

GP6 encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. Additionally we are shipping GP6 Antibodies (72) and GP6 Kits (31) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GP6 243816 P0C191
GP6 51206 Q9HCN6
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Top GP6 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$767.80
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$936.27
Details

GP6 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
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Human ,
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More Proteins for Glycoprotein VI (Platelet) (GP6) Interaction Partners

Mouse (Murine) Glycoprotein VI (Platelet) (GP6) interaction partners

  1. Inhibition of platelet activation by an anti-GPVI antibody significantly reduces infarct size.

  2. These results demonstrate that GPVI is a receptor for fibrin and provide evidence that this interaction contributes to thrombus growth and stability.

  3. data demonstrate that genetic deletion of GPVI receptor, FcRgamma (show FCER1G Proteins) chain, or the alpha2beta1 integrin changes the thrombotic potentials of these platelets to collagen dependent on the stimulus mechanism.

  4. data suggest a novel role for FAK (show PTK2 Proteins) in GPVI-dependent ROS (show ROS1 Proteins) formation and platelet activation and elucidate a proximal signaling role for FAK (show PTK2 Proteins) within the GPVI pathway.

  5. our results show that GPVI plays a dual role in inflammation by enhancing neutrophil-damaging activities while supporting the activation and hemostatic adhesion of single platelets to neutrophil-induced vascular breaches.

  6. This study identifies GPVI as a platelet receptor for polymerized fibrin with 2 major functions: (1) amplification of thrombin (show F2 Proteins) generation and (2) recruitment of circulating platelets to clots.

  7. Functional studies of platelets from Ceacam2 (show CEACAM2 Proteins)(-/-)-deficient mice (Cc2 (show TSG101 Proteins)(-/-)) revealed that CEACAM2 (show CEACAM2 Proteins) serves to negatively regulate collagen glycoprotein VI (platelet) (GPVI)-FcRgamma (show FCER1G Proteins)-chain and the C-type lectinlike receptor 2 (CLEC-2 (show CLEC1B Proteins)) signaling

  8. Glaucocalyxin A inhibits platelet activation and thrombus formation preferentially via GPVI signaling pathway.

  9. a delayed and markedly reduced thrombogenic response was still evident in VWF (show VWF Proteins)(-/-), GPVI, and alpha2beta1 blocked animals, suggesting that alternative primary hemostatic mechanisms can partially rescue the bleeding phenotype associated with these defects.

  10. RhoG is expressed and activated in platelets, plays an important role in GPVI-Fc receptor gamma-chain (show FCER1G Proteins) complex-mediated platelet activation, and is critical for thrombus formation in vivo.

Human Glycoprotein VI (Platelet) (GP6) interaction partners

  1. results support the idea that genetic variability of GP6 regulatory regions can be associated with platelet hyperaggregability - a possible cause of miscarriage

  2. These results demonstrate that GP6 is a receptor for fibrin and provide evidence that this interaction contributes to thrombus growth and stability.

  3. data suggest a novel role for FAK (show PTK2 Proteins) in GPVI-dependent ROS (show ROS1 Proteins) formation and platelet activation and elucidate a proximal signaling role for FAK (show PTK2 Proteins) within the GPVI pathway.

  4. This study identifies GPVI as a platelet receptor for polymerized fibrin with 2 major functions: (1) amplification of thrombin (show F2 Proteins) generation and (2) recruitment of circulating platelets to clots.

  5. Glaucocalyxin A inhibits platelet activation and thrombus formation preferentially via GPVI signaling pathway.

  6. The plasma levels of sGPVI were the highest in patients with TMA without markedly reduced ADAMTS13 (show ADAMTS13 Proteins) and those were significantly reduced after plasma exchange.

  7. Results suggest that variants of GP6 SNPs, namely, rs1671153, rs1654410, rs1654419, and rs1613662, may be associated with risk of recurrent miscarriage.

  8. Lower platelet GPIV (show CD36 Proteins) levels are associated with no-reflow phenomenon in patients with acute myocardial infarction.

  9. Studies indicate that Megakaryocyte maturation is accompanied by up-regulation of glycoprotein VI and down-regulation of leukocyte-associated immunoglobulin-like receptor-1 (show LAIR1 Proteins).

  10. The identification of four unrelated homozygous patients with an identical defect suggests that inherited GPVI deficiency is more frequent than previously suspected, at least in Chile

GP6 Protein Profile

Protein Summary

This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with GP6

  • glycoprotein VI (platelet) (GP6)
  • glycoprotein 6 (platelet) (Gp6)
  • 9830166G18Rik protein
  • BDPLT11 protein
  • Gm469 protein
  • GPIV protein
  • GPVI protein

Protein level used designations for GP6

glycoprotein VI (platelet) , glycoprotein 5 , platelet glycoprotein VI , glycoprotein 6 , platelet collagen receptor

GENE ID SPECIES
456429 Pan troglodytes
484303 Canis lupus familiaris
243816 Mus musculus
51206 Homo sapiens
100141420 Sus scrofa
101123066 Ovis aries
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