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GP6 encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. Additionally we are shipping GP6 Kits (29) and GP6 Proteins (6) and many more products for this protein.
Showing 10 out of 77 products:
Human Polyclonal GP6 Primary Antibody for WB - ABIN2782886
Gardiner, Karunakaran, Arthur, Mu, Powell, Baker, Hogarth, Kahn, Andrews, Berndt: Dual ITAM-mediated proteolytic pathways for irreversible inactivation of platelet receptors: de-ITAM-izing FcgammaRIIa. in Blood 2007
These results reveal a novel and unexpected function of hepatic Fc-gamma-RIIB in the targeted downregulation of GPVI in vivo.
collagen-I-mediated inhibition of proplatelet formation is specifically controlled by GPVI.
platelet GP6 and thromboxane A2 receptor (show TBXA2R Antibodies) have a role in promoting inflammatory macrophage phenotype in skin inflammation
Novel antithrombotic peptides derived from trowaglerix that acts through GPVI antagonism with greater safety-no severe bleeding.
TULA-2 (show STS1 Antibodies) Protein Phosphatase Suppresses Activation of Syk (show SYK Antibodies) through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr (show TYR Antibodies)(P)346, a Regulatory Site of Syk (show SYK Antibodies).
Inhibition of platelet activation by an anti-GPVI antibody significantly reduces infarct size.
These results demonstrate that GPVI is a receptor for fibrin and provide evidence that this interaction contributes to thrombus growth and stability.
data demonstrate that genetic deletion of GPVI receptor, FcRgamma (show FCER1G Antibodies) chain, or the alpha2beta1 integrin changes the thrombotic potentials of these platelets to collagen dependent on the stimulus mechanism.
data suggest a novel role for FAK (show PTK2 Antibodies) in GPVI-dependent ROS (show ROS1 Antibodies) formation and platelet activation and elucidate a proximal signaling role for FAK (show PTK2 Antibodies) within the GPVI pathway.
our results show that GPVI plays a dual role in inflammation by enhancing neutrophil-damaging activities while supporting the activation and hemostatic adhesion of single platelets to neutrophil-induced vascular breaches.
results support the idea that genetic variability of GP6 regulatory regions can be associated with platelet hyperaggregability - a possible cause of miscarriage
These results demonstrate that GP6 is a receptor for fibrin and provide evidence that this interaction contributes to thrombus growth and stability.
This study identifies GPVI as a platelet receptor for polymerized fibrin with 2 major functions: (1) amplification of thrombin (show F2 Antibodies) generation and (2) recruitment of circulating platelets to clots.
Glaucocalyxin A inhibits platelet activation and thrombus formation preferentially via GPVI signaling pathway.
The plasma levels of sGPVI were the highest in patients with TMA without markedly reduced ADAMTS13 (show ADAMTS13 Antibodies) and those were significantly reduced after plasma exchange.
Results suggest that variants of GP6 SNPs, namely, rs1671153, rs1654410, rs1654419, and rs1613662, may be associated with risk of recurrent miscarriage.
Lower platelet GPIV (show CD36 Antibodies) levels are associated with no-reflow phenomenon in patients with acute myocardial infarction.
Studies indicate that Megakaryocyte maturation is accompanied by up-regulation of glycoprotein VI and down-regulation of leukocyte-associated immunoglobulin-like receptor-1 (show LAIR1 Antibodies).
This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
glycoprotein VI (platelet)
, glycoprotein 5
, platelet glycoprotein VI
, glycoprotein 6
, platelet collagen receptor