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anti-Glycyl-tRNA Synthetase (GARS) Antibodies

GARS encodes glycyl-tRNA synthetase, one of the aminoacyl-tRNA synthetases that charge tRNAs with their cognate amino acids. Additionally we are shipping Glycyl-tRNA Synthetase Kits (12) and Glycyl-tRNA Synthetase Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GARS 2617 P41250
GARS 353172 Q9CZD3
GARS 297113  
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Top anti-Glycyl-tRNA Synthetase Antibodies at antibodies-online.com

Showing 10 out of 61 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-GARS Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: MCF7 cell lysate WB Suggested Anti-GARS  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500  Positive Control: MCF7 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-GARS Antibody (C-term) (ABIN392465) in Ramos cell line lysates (35 µg/lane). GARS (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated ELISA, WB Western Blot: GARS Antibody (4E10) [NBP2-42679] - The cell lysates of Hela and 293T (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human GARS antibody 1:500. Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. 100 μL Log in to see 8 to 11 Days
$381.94
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated IF, IHC, WB 100 μL Log in to see 14 Days
$323.13
Details
Human Mouse Un-conjugated IHC Immunohistochemistry: GARS Antibody (4G4) [NBP2-45808] - Analysis of Human Kidney tissue. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min) Immunohistochemistry: GARS Antibody (4G4) [NBP2-45808] - Analysis of Carcinoma of Human liver tissue.(Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min) 0.1 mL Log in to see 6 to 9 Days
$447.56
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: GARS Antibody [NBP1-85533] - Staining of human cell line U-2 OS shows positivity in cytoplasm. Western Blot: GARS Antibody [NBP1-85533] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp 0.1 mL Log in to see 8 to 11 Days
$439.69
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: GARS Antibody [NBP1-85534] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells).Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells) Western Blot: GARS Antibody [NBP1-85534] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp 0.1 mL Log in to see 8 to 11 Days
$439.69
Details
Human Rabbit Un-conjugated WB Western Blot: GARS Antibody [NBP1-54602] - MCF-7 whole cell lysates, concentration 0.2-1 ug/ml. 100 μL Log in to see 6 to 9 Days
$447.56
Details

GARS Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Glycyl-tRNA Synthetase Antibodies

  1. Human Polyclonal GARS Primary Antibody for WB - ABIN392465 : Shiba, Schimmel, Motegi, Noda: Human glycyl-tRNA synthetase. Wide divergence of primary structure from bacterial counterpart and species-specific aminoacylation. in The Journal of biological chemistry 1994 (PubMed)
    Show all 2 references for ABIN392465

  2. Human Polyclonal GARS Primary Antibody for EIA, WB - ABIN360353 : Antonellis, Ellsworth, Sambuughin, Puls, Abel, Lee-Lin, Jordanova, Kremensky, Christodoulou, Middleton, Sivakumar, Ionasescu, Funalot, Vance, Goldfarb, Fischbeck, Green: Glycyl tRNA synthetase mutations in Charcot-Marie-Tooth disease type 2D and distal spinal muscular atrophy type V. in American journal of human genetics 2003 (PubMed)
    Show all 2 references for ABIN360353

  3. Chicken Polyclonal GARS Primary Antibody for WB - ABIN2787816 : Förster, Zerressen-Harte, Fürste, Perbandt, Betzel, Erdmann: Comparative X-ray structure analysis of human and Escherichia coli tRNA(Gly) acceptor stem microhelices. in Biochemical and biophysical research communications 2008 (PubMed)

More Antibodies against Glycyl-tRNA Synthetase Interaction Partners

Fruit Fly (Drosophila melanogaster) Glycyl-tRNA Synthetase (GARS) interaction partners

  1. Our findings suggest that mutant GlyRS gains access to ectopic sub-compartments of the motor neuron, providing a possible explanation for the selective neuropathology caused by mutations in a widely expressed gene.

Human Glycyl-tRNA Synthetase (GARS) interaction partners

  1. Data indicate that dimerization is required for the dominant neurotoxicity of disease-associated GARS mutations and provide a rapid, tractable model for studying newly identified GARS variants for a role in human disease.

  2. one of the mRNAs isoforms tightly controls expression and localization of human GARS.

  3. This study reports two crystal structures of human GlyRS variants, in the free form and in complex with tRNA(Gly) respectively, and reveal new aspects of the glycylation mechanism.

  4. GARS mutations are an uncommon cause of Charcot-Marie-Tooth Disease (CMT) in Taiwan. The p.Asp146Tyr and p.Met238Arg mutations are associated with early-onset axonal CMT.

  5. Our findings suggest that mutant GlyRS gains access to ectopic sub-compartments of the motor neuron, providing a possible explanation for the selective neuropathology caused by mutations in a widely expressed gene.

  6. Expression of three CMT-mutant GARS proteins in Drosophila induces defects in motor performance and motor and sensory neuron morphology, and shortens lifespan.

  7. The c.999G>T mutation is a novel mutation of the glycyl-tRNA synthetase gene that has not been previously reported. The phenotype of this family is Charcot-Marie-Tooth disease type 2D, which is first reported in Chinese population.

  8. we propose that the disease-causing L129P mutant of glycyl-tRNA synthetase is linked to a distribution defect in peripheral nerves in vivo.

  9. our data indicate that impaired function is a key component of GARS-mediated CMT disease and emphasize the need for careful genetic and functional evaluation before implicating a variant in disease onset.

  10. We developed an ELISA to detect anti-glycyl-tRNA synthetase by using recombinant protein

Mouse (Murine) Glycyl-tRNA Synthetase (GARS) interaction partners

  1. findings link the selective pathology of Charcot-Marie-Tooth disease type 2D to the neomorphic binding activity of GlyRS(CMT2D) that antagonizes the VEGF (show VEGFA Antibodies)-Nrp1 (show NRP1 Antibodies) interaction, meaning the VEGF (show VEGFA Antibodies)-Nrp1 (show NRP1 Antibodies) signalling axis is an actionable target for treating CMT2D

  2. Results indicate that Charcot-Marie-Tooth peripheral neuropathies, type 2D (CMT2D) phenotype is caused by novel pathogenic roles for the mutant GARS that specifically affect peripheral neurons.

  3. a glycyl-tRNA synthetase (GARS) mutation causes peripheral sensory and motor phenotypes creating a model of Charcot-Marie-Tooth type 2D peripheral neuropathy

  4. Gars(C201R) mutation significantly delayed disease onset in the SOD1 (show SOD1 Antibodies)(G93A);Gars(C201R/+) double heterozygous mutant mice and increased lifespan by 29% on the genetic background investigated

Zebrafish Glycyl-tRNA Synthetase (GARS) interaction partners

  1. Data indicate that dimerization is required for the dominant neurotoxicity of disease-associated GARS mutations and provide a rapid, tractable model for studying newly identified GARS variants for a role in human disease.

Pig (Porcine) Glycyl-tRNA Synthetase (GARS) interaction partners

  1. Expression levels of ADSL (show ADSL Antibodies), GARS-AIRS-GART (show GART Antibodies), and DGAT1 (show DGAT1 Antibodies) were higher in longissimus lumborum muscle than in heart or liver tissues

Glycyl-tRNA Synthetase (GARS) Antigen Profile

Protein Summary

This gene encodes glycyl-tRNA synthetase, one of the aminoacyl-tRNA synthetases that charge tRNAs with their cognate amino acids. The encoded enzyme is an (alpha)2 dimer which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis.

Gene names and symbols associated with GARS

  • Glycyl-tRNA synthetase (Aats-gly) antibody
  • glycyl-tRNA synthetase (Aats-gly) antibody
  • glycyl-tRNA synthetase (GARS) antibody
  • glycyl-tRNA synthetase (gars) antibody
  • glycyl-tRNA synthetase (glyQ) antibody
  • glycyl-tRNA synthetase (TTHA0543) antibody
  • glycyl-tRNA synthetase (Gars) antibody
  • glycyl-tRNA synthetase (LOC692991) antibody
  • glycyl-tRNA synthetase-like (LOC100512260) antibody
  • Aat-gly antibody
  • CG6778 antibody
  • CMT2D antibody
  • Dmel\\CG6778 antibody
  • DSMAV antibody
  • fb02f03 antibody
  • gars antibody
  • GB13467 antibody
  • Gena201 antibody
  • GENA202 antibody
  • GlyRS antibody
  • GRS antibody
  • HMN5 antibody
  • MGC79495 antibody
  • Nmf249 antibody
  • RGD1559871 antibody
  • Sgrp23 antibody
  • si:dkey-276i5.1 antibody
  • SMAD1 antibody
  • team antibody
  • wu:fb02f03 antibody

Protein level used designations for GARS

Aats-gly-PA , Aats-gly-PB , Aats-gly-PC , CG6778-PA , CG6778-PB , CG6778-PC , glycyl-tRNA synthetase , glycine--tRNA ligase , AP-4-A synthetase , Charcot-Marie-Tooth neuropathy 2D , Charcot-Marie-Tooth neuropathy, neuronal type, D , diadenosine tetraphosphate synthetase , glycine tRNA ligase , glyRS , storage granule protein 23 , glycyl-tran synthetase

GENE ID SPECIES
39644 Drosophila melanogaster
408392 Apis mellifera
463329 Pan troglodytes
475268 Canis lupus familiaris
493218 Xenopus (Silurana) tropicalis
884595 Chlamydia trachomatis D/UW-3/CX
3169948 Thermus thermophilus HB8
100388470 Callithrix jacchus
2617 Homo sapiens
353172 Mus musculus
297113 Rattus norvegicus
337230 Danio rerio
446482 Xenopus laevis
428403 Gallus gallus
408010 Bos taurus
692991 Bombyx mori
100174405 Pongo abelii
100512260 Sus scrofa
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