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Glypican 3 Proteins (GPC3)

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Additionally we are shipping Glypican 3 Antibodies (172) and Glypican 3 Kits (57) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GPC3 2719 P51654
GPC3 14734 Q8CFZ4
GPC3 25236 P13265
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Top Glypican 3 Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 100 μg Log in to see 2 to 3 Days
$275.00
Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Baculovirus infected Insect Cells Mouse His tag 100 μg Log in to see 16 Days
$382.80
Details
Yeast Rat His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 11 to 13 Days
$668.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$735.90
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_HEK-293 Human His tag   0.1 mg Log in to see 2 to 3 Days
$515.63
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 7 Days
$1,281.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 5 to 9 Days
$1,235.25
Details

GPC3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine) ,
,
Rat (Rattus)

Top referenced Glypican 3 Proteins

  1. Human Glypican 3 Protein expressed in Escherichia coli (E. coli) - ABIN1880377 : Capurro, Xu, Shi, Li, Jia, Filmus: Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding. in Developmental cell 2008 (PubMed)
    Show all 2 references for ABIN1880377

  2. Human Glypican 3 Protein expressed in HEK-293 Cells - ABIN2181182 : Davoodi, Kelly, Gendron, MacKenzie: The Simpson-Golabi-Behmel syndrome causative glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26. in Proteomics 2007 (PubMed)
    Show all 2 references for ABIN2181182

  3. Human Glypican 3 Protein expressed in Human Cells - ABIN2002041 : De Cat, Muyldermans, Coomans, Degeest, Vanderschueren, Creemers, Biemar, Peers, David: Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements. in The Journal of cell biology 2003 (PubMed)

More Proteins for Glypican 3 (GPC3) Interaction Partners

Human Glypican 3 (GPC3) interaction partners

  1. Glypican 3 expression showed a significant difference between endometrioid endometrial carcinoma and serous endometrial carcinoma, and it was significantly correlated with tumor grade, stage and myometrial invasion

  2. Data show that notum (show NOTUM Proteins) and glypican-1 (show GPC1 Proteins) and glypican-3 gene expression during colorectal cancer (CRC (show CALR Proteins)) development and present evidence to suggest them as potential new biomarkers of CRC (show CALR Proteins) pathogenesis.

  3. GPC3 expression was measured in hepatocellular carcinoma at different stages and correlated with prognosis. CK19 (show KRT19 Proteins)+/GPC3+ HCC (show FAM126A Proteins) has the highest risk of intrahepatic metastasis, microvascular invasion, regional lymph node involvement, and distant metastasis.

  4. Review: Glypican-3 is a highly specific biomarker for the diagnosis of hepatocellular carcinoma and a promising therapeutic target.

  5. In South Korean hepatocellular carcinoma patients, GPC3 expression was more frequent in hepatocellular carcinoma with aggressive features, but it was not an independent prognostic biomarker.

  6. In this meta-analysis, GPC3 was found to be acceptable as a serum marker for the diagnosis of hepatocellular carcinoma.

  7. GPC3 may be a candidate marker for detecting lung squamous cell carcinoma.

  8. study suggests that GPC3 is involved in HCC (show FAM126A Proteins) cell migration and motility through HS chain-mediated cooperation with the HGF (show HGF Proteins)/Met pathway, showing how HS targeting has potential therapeutic implications for liver cancer

  9. potential role of GPC3 in urothelial carcinogenesis warrants further investigation, especially the potential use of Glypican-3 for therapeutic and diagnostic purposes

  10. Downregulation of glypican-3 expression increases migration, invasion, and tumorigenicity of ovarian cancer.

Mouse (Murine) Glypican 3 (GPC3) interaction partners

  1. Data show that notum (show NOTUM Proteins) and glypican-1 (show GPC1 Proteins) and glypican-3 gene expression during colorectal cancer (CRC) development and present evidence to suggest them as potential new biomarkers of CRC pathogenesis.

  2. Coupling of pGPC3 to liposomes was essential for effective priming of GPC3-specific CTLs.

  3. The expression of GPC-3 was altered by DEN treatment.

  4. Data suggest that GPC3 down-regulates hepatocyte proliferation by binding to hedgehog (show SHH Proteins) (HH) and down-regulating the HH signaling pathway and binding with CD81 (show CD81 Proteins), thus making it unavailable to bind to Hhex (show HHEX Proteins) and causing its nuclear translocation.

  5. Finding represents a rare four layer genomic overlap consisting of growth associated quantitative trait locus (QTL), body mass associated Gpc3 gene, highly conserved miRNA gene and mature miRNA seed SNP identified in the lean mouse.

  6. Hepatocyte overexpression of GPC3 suppresses hepatocyte proliferation and liver regeneration and alters gene expression profiles.

  7. glypican-3 is involved in the recruitment of M2-polarized tumor-associated macrophages in hepatocellular carcinoma

  8. GPC3 inhibits the PI3K/Akt (show AKT1 Proteins) anti-apoptotic pathway while it stimulates the p38MAPK (show MAPK14 Proteins) stress-activated one in murine mammary adenocarcinoma LM3 cells

  9. Gpc3 function in development of Simpson-Golabi-Behmel syndrome is IGF-independent

  10. GPC3 knockout mice exhibit alterations in the Wnt (show WNT2 Proteins) signaling pathway, which is also associated with the regulation of cell proliferation

Glypican 3 (GPC3) Protein Profile

Protein Summary

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with Glypican 3 Proteins (GPC3)

  • glypican 3 (gpc3)
  • glypican 3 (GPC3)
  • glypican 3 (Gpc3)
  • DGSX protein
  • Glypican-3 protein
  • GPC3 protein
  • GTR2-2 protein
  • MXR7 protein
  • OCI-5 protein
  • SDYS protein
  • SGB protein
  • SGBS protein
  • SGBS1 protein

Protein level used designations for Glypican 3 Proteins (GPC3)

glypican 3 , glypican-3-like , glypican proteoglycan 3 , glypican-3 , heparan sulphate proteoglycan , intestinal protein OCI-5 , secreted glypican-3 , defective in Simpson-Golabi-Behmel overgrowth syndrome , proteoglycan GPC3 , Intestinal protein OCI-5

GENE ID SPECIES
387365 Danio rerio
706773 Macaca mulatta
100023253 Monodelphis domestica
100135027 Xenopus (Silurana) tropicalis
100401118 Callithrix jacchus
100444952 Pongo abelii
100477314 Ailuropoda melanoleuca
100548246 Meleagris gallopavo
100591673 Nomascus leucogenys
2719 Homo sapiens
481056 Canis lupus familiaris
615239 Bos taurus
14734 Mus musculus
25236 Rattus norvegicus
100351858 Oryctolagus cuniculus
100726246 Cavia porcellus
100516171 Sus scrofa
770863 Gallus gallus
101119285 Ovis aries
465866 Pan troglodytes
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