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Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Additionally we are shipping Glypican 3 Antibodies (286) and Glypican 3 Kits (47) and many more products for this protein.
Showing 10 out of 22 products:
Human Glypican 3 Protein expressed in Escherichia coli (E. coli) - ABIN1880377
Capurro, Xu, Shi, Li, Jia, Filmus: Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding. in Developmental cell 2008
Show all 2 references for ABIN1880377
Human Glypican 3 Protein expressed in HEK-293 Cells - ABIN2181182
Davoodi, Kelly, Gendron, MacKenzie: The Simpson-Golabi-Behmel syndrome causative glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26. in Proteomics 2007
Show all 2 references for ABIN2181182
Mouse (Murine) Glypican 3 Protein expressed in Baculovirus infected Insect Cells - ABIN2008482
De Cat, Muyldermans, Coomans, Degeest, Vanderschueren, Creemers, Biemar, Peers, David: Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements. in The Journal of cell biology 2003
The clinical implication of GPC3 detection and targeting in the management of patients with hepatocellular carcinoma. Review.
Glypican 3 expression showed a significant difference between endometrioid endometrial carcinoma and serous endometrial carcinoma, and it was significantly correlated with tumor grade, stage and myometrial invasion
Data show that notum (show NOTUM Proteins) and glypican-1 (show GPC1 Proteins) and glypican-3 gene expression during colorectal cancer (CRC (show CALR Proteins)) development and present evidence to suggest them as potential new biomarkers of CRC (show CALR Proteins) pathogenesis.
GPC3 expression was measured in hepatocellular carcinoma at different stages and correlated with prognosis. CK19 (show KRT19 Proteins)+/GPC3+ HCC (show FAM126A Proteins) has the highest risk of intrahepatic metastasis, microvascular invasion, regional lymph node involvement, and distant metastasis.
Review: Glypican-3 is a highly specific biomarker for the diagnosis of hepatocellular carcinoma and a promising therapeutic target.
In South Korean hepatocellular carcinoma patients, GPC3 expression was more frequent in hepatocellular carcinoma with aggressive features, but it was not an independent prognostic biomarker.
In this meta-analysis, GPC3 was found to be acceptable as a serum marker for the diagnosis of hepatocellular carcinoma.
GPC3 may be a candidate marker for detecting lung squamous cell carcinoma.
study suggests that GPC3 is involved in HCC (show FAM126A Proteins) cell migration and motility through HS chain-mediated cooperation with the HGF (show HGF Proteins)/Met pathway, showing how HS targeting has potential therapeutic implications for liver cancer
potential role of GPC3 in urothelial carcinogenesis warrants further investigation, especially the potential use of Glypican-3 for therapeutic and diagnostic purposes
Data show that notum (show NOTUM Proteins) and glypican-1 (show GPC1 Proteins) and glypican-3 gene expression during colorectal cancer (CRC) development and present evidence to suggest them as potential new biomarkers of CRC pathogenesis.
Coupling of pGPC3 to liposomes was essential for effective priming of GPC3-specific CTLs.
The expression of GPC-3 was altered by DEN treatment.
Data suggest that GPC3 down-regulates hepatocyte proliferation by binding to hedgehog (show SHH Proteins) (HH) and down-regulating the HH signaling pathway and binding with CD81 (show CD81 Proteins), thus making it unavailable to bind to Hhex (show HHEX Proteins) and causing its nuclear translocation.
Finding represents a rare four layer genomic overlap consisting of growth associated quantitative trait locus (QTL), body mass associated Gpc3 gene, highly conserved miRNA gene and mature miRNA seed SNP identified in the lean mouse.
Hepatocyte overexpression of GPC3 suppresses hepatocyte proliferation and liver regeneration and alters gene expression profiles.
glypican-3 is involved in the recruitment of M2-polarized tumor-associated macrophages in hepatocellular carcinoma
GPC3 inhibits the PI3K/Akt (show AKT1 Proteins) anti-apoptotic pathway while it stimulates the p38MAPK (show MAPK14 Proteins) stress-activated one in murine mammary adenocarcinoma LM3 cells
Gpc3 function in development of Simpson-Golabi-Behmel syndrome is IGF-independent
GPC3 knockout mice exhibit alterations in the Wnt (show WNT2 Proteins) signaling pathway, which is also associated with the regulation of cell proliferation
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants.
, glypican proteoglycan 3
, heparan sulphate proteoglycan
, intestinal protein OCI-5
, secreted glypican-3
, defective in Simpson-Golabi-Behmel overgrowth syndrome
, proteoglycan GPC3
, Intestinal protein OCI-5