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The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans, and they have been implicated in the control of cell growth and cell division. Additionally we are shipping Glypican 6 Antibodies (52) and Glypican 6 Proteins (7) and many more products for this protein.
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Thus, GPC6 and TMEM132D may serve as predictors of CD8 (show CD8A ELISA Kits)+ T-lymphocyte infiltration and as favorable prognostic markers in early stage ovarian cancer with important consequences for diagnosis.
GPC6 promotes invasive migration by inhibition of canonical beta-catenin (show CTNNB1 ELISA Kits) and Wnt (show WNT2 ELISA Kits) signalling, and up-regulation of non-canonical Wnt5A (show WNT5A ELISA Kits) signalling leading to the activation of JNK (show MAPK8 ELISA Kits) and p38 MAPK (show MAPK14 ELISA Kits).
a reduction in GPC6 mRNA in retinoblastoma is associated with the non-random allelic loss at 13q31 that could contribute to RB development.
Mutations in the heparan-sulfate proteoglycan glypican 6 impair endochondral ossification and cause recessive omodysplasia
data identify glypicans as a family of novel astrocyte-derived molecules that are necessary and sufficient to promote glutamate (show GRIN1 ELISA Kits) receptor clustering and receptivity and to induce the formation of postsynaptically functioning CNS synapses
The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans, and they have been implicated in the control of cell growth and cell division. The glypican encoded by this gene is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases.
, glypican proteoglycan 6