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The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans, and they have been implicated in the control of cell growth and cell division. Additionally we are shipping Glypican 6 Antibodies (41) and Glypican 6 Kits (2) and many more products for this protein.
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Thus, GPC6 and TMEM132D may serve as predictors of CD8 (show CD8A Proteins)+ T-lymphocyte infiltration and as favorable prognostic markers in early stage ovarian cancer with important consequences for diagnosis.
GPC6 promotes invasive migration by inhibition of canonical beta-catenin (show CTNNB1 Proteins) and Wnt (show WNT2 Proteins) signalling, and up-regulation of non-canonical Wnt5A (show WNT5A Proteins) signalling leading to the activation of JNK (show MAPK8 Proteins) and p38 MAPK (show MAPK14 Proteins).
a reduction in GPC6 mRNA in retinoblastoma is associated with the non-random allelic loss at 13q31 that could contribute to RB development.
Mutations in the heparan-sulfate proteoglycan glypican 6 impair endochondral ossification and cause recessive omodysplasia
data identify glypicans as a family of novel astrocyte-derived molecules that are necessary and sufficient to promote glutamate (show GRIN1 Proteins) receptor clustering and receptivity and to induce the formation of postsynaptically functioning CNS synapses
The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans, and they have been implicated in the control of cell growth and cell division. The glypican encoded by this gene is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases.
, glypican proteoglycan 6