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The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. Additionally we are shipping Golgi Reassembly Stacking Protein 1, 65kDa Proteins (6) and many more products for this protein.
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In cells, Mena and actin were required for Golgi ribbon formation after nocodazole washout; in vitro, Mena and microfilaments enhanced GRASP65 oligomerization and Golgi membrane fusion. Thus Mena interacts with GRASP65 to promote local actin polymerization, which facilitates Golgi ribbon linking.
Mutagenesis experiments support these structural observations and demonstrate that they are required for GRASP65-GM130 (show GOLGA2 Antibodies) association.
Cisternal-specific functions of GRASP65 and GRASP55 (show GORASP2 Antibodies) in continuity, compartmentalization, and function of the Golgi ribbon.
propose that GRASP55 (show GORASP2 Antibodies)/65 are negative regulators of exocytic transport and that this slowdown helps to ensure more complete protein glycosylation in the Golgi stack and proper sorting at the trans-Golgi network
The C-terminal fragments of GRASP65 produced following caspase (show CASP3 Antibodies) cleavage are targeted to mitochondria, and ectopic expression of these sensitises HeLa cells to Fas ligand (show FASL Antibodies).
the mechanism of phosphoinhibition as direct inhibition by PLK1 (show PLK1 Antibodies) of the PDZ (show INADL Antibodies) ligand underlying the GRASP65 self-interaction.
GRASP65 has a role in Golgi cisternal stacking and cell cycle progression
These results demonstrate that GRASP55 (show GORASP2 Antibodies) and GRASP65 stack mammalian Golgi cisternae via a common mechanism.
Data demonstrate that both GRASP55 (show GORASP2 Antibodies) and 65 are needed for the efficient transport to and through the Golgi complex, thus highlighting a novel role for the GRASPs in membrane trafficking.
the GRASP domain alone of GRASP65 inhibits mitotic fragmentation of the Golgi apparatus
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a membrane protein involved in establishing the stacked structure of the Golgi apparatus. It is a caspase-3 substrate, and cleavage of this encoded protein contributes to Golgi fragmentation in apoptosis. This encoded protein can form a complex with the Golgi matrix protein GOLGA2, and this complex binds to the vesicle docking protein p115. Several alternatively spliced transcript variants of this gene have been identified, but their full-length natures have not been determined.
Golgi reassembly-stacking protein 1
, golgi reassembly stacking protein 1, 65kDa
, golgi reassembly stacking protein 1
, golgi reassembly-stacking protein 1-like
, Golgi reassembly-stacking protein 1-like
, golgi perepheral membrane protein p65
, golgi peripheral membrane protein p65
, golgi reassembly-stacking protein of 65 kDa
, Golgi peripheral membrane protein p65
, Golgi phosphoprotein 5
, Golgi reassembly and stacking protein 1