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GGA1 encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Additionally we are shipping GGA1 Antibodies (60) and GGA1 Proteins (4) and many more products for this protein.
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novel protein complex composed of Rabep1 (show RABEP1 ELISA Kits), GGA1 and Arl3 is responsible for the sorting and targeting of the polycystin 1 (show PKD1 ELISA Kits) andpolycystin 2 to the cilium.
GGA1 interacts with internal LRP9 and LRP12 (show LRP12 ELISA Kits) DXXLL motifs.
depletion of GGA1 and GGA3 (show GGA3 ELISA Kits) engender a rapid and robust elevation of BACE1 (show BACE ELISA Kits) in the acute phase after brain injury.
termination of Arf1 (show ARF1 ELISA Kits) signals mediated through GGA require that Arf1 (show ARF1 ELISA Kits).GTP (show AK3 ELISA Kits) dissociates from GGA prior to interaction with GAP and consequent hydrolysis of GTP (show AK3 ELISA Kits)
serine phosphorylation of BACE (show BACE ELISA Kits) is a physiologically relevant post-translational modification that regulates trafficking in the juxtanuclear compartment by interaction with GGA1
Glut4 (show SLC2A4 ELISA Kits) insulin (show INS ELISA Kits)-responsive trafficking is mediated by GGA adaptors in mouse adipocytes
the trafficking of adiponectin (show ADIPOQ ELISA Kits) through its secretory pathway is dependent on GGA-coated vesicles
These findings show that the AD-like phenotype of NPC (show NPC1 ELISA Kits) model cells can be partly reverted by promoting a non-amyloidogenic processing of APP (show APP ELISA Kits) through the upregulation of GGA1 supporting its preventive role against AD
These data indicate that clathrin is required for the function of AP-1 (show FOSB ELISA Kits)- and GGA-coated carriers at the trans-Golgi network but may be dispensable for outward traffic en route to the plasma membrane.
On basis of these results, propose that GGA1 facilitates LR11 (show SORL1 ELISA Kits) endocytic traffic and that LR11 (show SORL1 ELISA Kits) modulates A-beta (show SUCLA2 ELISA Kits) levels by promoting amyloid-beta precursor protein traffic to the endocytic recycling compartment
X-ray structure of the GGA1 VHS domain alone, and in complex with the carboxy-terminal peptide of cation-independent mannose 6-phosphate receptor (show IGF2R ELISA Kits) containing an ACLL sequence
endocytosis and intracellular transport of memapsin 2 (show BACE ELISA Kits), mediated by its cytosolic domain, may involve the binding of GGA1 and GGA2 (show GGA2 ELISA Kits)
The 2.4-A crystal structure of the GAT domain of human GGA1 reveals a three-helix bundle, with a long N-terminal helical extension that is not conserved in GAT domains that do not bind ARF.
X-ray crystal structures of the human GGA1-GAT domain and the complex between ARF1-GTP and the N-terminal region of the GAT domain
Crystal structure of the human GGA1 GAT domain
A hydrophobic surface patch on the C-terminal three-helix bundle motif of the GGA1 GAT (show GLYAT ELISA Kits) domain is directly involved in binding with a coiled-coil region of rabaptin-5 (show RABEP1 ELISA Kits).
GGA1 interacts with the adaptor protein AP-1 (show FOSB ELISA Kits) through a WNSF sequence in its hinge region
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
golgi associated gamma adaptin ear containing arf binding protein 1 (gga1)
, ADP-ribosylation factor-binding protein GGA1
, gamma-adaptin-related protein 1
, golgi-localized, gamma ear-containing, ARF-binding protein 1
, ADP-ribosylation factor binding protein 1
, gamma-adaptin related protein 1
, golgi associated, gamma adaptin ear containing, ARF binding protein 1