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Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 1 Proteins (GGA1)

GGA1 encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Additionally we are shipping GGA1 Antibodies (61) and GGA1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GGA1 106039 Q8R0H9
Rat GGA1 GGA1 300066  
GGA1 26088 Q9UJY5
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Top GGA1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

GGA1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 1 (GGA1) Interaction Partners

Mouse (Murine) Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 1 (GGA1) interaction partners

  1. novel protein complex composed of Rabep1, GGA1 and Arl3 is responsible for the sorting and targeting of the polycystin 1 (show PKD1 Proteins) andpolycystin 2 to the cilium.

  2. GGA1 interacts with internal LRP9 (show LRP10 Proteins) and LRP12 (show LRP12 Proteins) DXXLL motifs.

  3. depletion of GGA1 and GGA3 (show GGA3 Proteins) engender a rapid and robust elevation of BACE1 (show BACE Proteins) in the acute phase after brain injury.

  4. termination of Arf1 (show ARF1 Proteins) signals mediated through GGA require that Arf1 (show ARF1 Proteins).GTP (show AK3 Proteins) dissociates from GGA prior to interaction with GAP and consequent hydrolysis of GTP (show AK3 Proteins)

  5. serine phosphorylation of BACE (show BACE Proteins) is a physiologically relevant post-translational modification that regulates trafficking in the juxtanuclear compartment by interaction with GGA1

  6. Glut4 (show SLC2A4 Proteins) insulin (show INS Proteins)-responsive trafficking is mediated by GGA adaptors in mouse adipocytes

  7. the trafficking of adiponectin (show ADIPOQ Proteins) through its secretory pathway is dependent on GGA-coated vesicles

Human Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 1 (GGA1) interaction partners

  1. These findings show that the AD-like phenotype of NPC (show NPC1 Proteins) model cells can be partly reverted by promoting a non-amyloidogenic processing of APP (show APP Proteins) through the upregulation of GGA1 supporting its preventive role against AD

  2. These data indicate that clathrin is required for the function of AP-1 (show FOSB Proteins)- and GGA-coated carriers at the trans-Golgi network but may be dispensable for outward traffic en route to the plasma membrane.

  3. On basis of these results, propose that GGA1 facilitates LR11 (show SORL1 Proteins) endocytic traffic and that LR11 (show SORL1 Proteins) modulates A-beta (show SUCLA2 Proteins) levels by promoting amyloid-beta precursor protein traffic to the endocytic recycling compartment

  4. X-ray structure of the GGA1 VHS domain alone, and in complex with the carboxy-terminal peptide of cation-independent mannose 6-phosphate receptor (show IGF2R Proteins) containing an ACLL sequence

  5. endocytosis and intracellular transport of memapsin 2 (show BACE Proteins), mediated by its cytosolic domain, may involve the binding of GGA1 and GGA2 (show GGA2 Proteins)

  6. The 2.4-A crystal structure of the GAT domain of human GGA1 reveals a three-helix bundle, with a long N-terminal helical extension that is not conserved in GAT domains that do not bind ARF.

  7. X-ray crystal structures of the human GGA1-GAT domain and the complex between ARF1-GTP and the N-terminal region of the GAT domain

  8. Crystal structure of the human GGA1 GAT domain

  9. A hydrophobic surface patch on the C-terminal three-helix bundle motif of the GGA1 GAT domain is directly involved in binding with a coiled-coil region of rabaptin-5.

  10. GGA1 interacts with the adaptor protein AP-1 (show FOSB Proteins) through a WNSF sequence in its hinge region

GGA1 Protein Profile

Protein Summary

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with GGA1

  • golgi associated gamma adaptin ear containing arf binding protein 1 (gga1) (Smp_164030)
  • golgi associated, gamma adaptin ear containing, ARF binding protein 1 (Gga1)
  • golgi associated, gamma adaptin ear containing, ARF binding protein 1 (gga1)
  • golgi-associated, gamma adaptin ear containing, ARF binding protein 1 (GGA1)
  • 4930406E12Rik protein
  • AU016030 protein
  • AW209092 protein
  • fb33h10 protein
  • im:6912200 protein
  • wu:fb33h10 protein
  • zgc:101044 protein

Protein level used designations for GGA1

golgi associated gamma adaptin ear containing arf binding protein 1 (gga1) , ADP-ribosylation factor-binding protein GGA1 , gamma-adaptin-related protein 1 , golgi-localized, gamma ear-containing, ARF-binding protein 1 , ADP-ribosylation factor binding protein 1 , gamma-adaptin related protein 1 , golgi associated, gamma adaptin ear containing, ARF binding protein 1

GENE ID SPECIES
8345265 Schistosoma mansoni
106039 Mus musculus
300066 Rattus norvegicus
798361 Danio rerio
26088 Homo sapiens
534634 Bos taurus
481266 Canis lupus familiaris
100623753 Sus scrofa
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