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GSC encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. Additionally we are shipping Goosecoid Homeobox Antibodies (85) and Goosecoid Homeobox Proteins (10) and many more products for this protein.
these data suggest that Lnx (show LNX1 ELISA Kits)-2b maintains the integrity of the ectodermal tissues via suppressing gsc expression which can be driven by the coordinated action of nodal-related factors and Boz.
FoxA3 (show FOXA3 ELISA Kits) and goosecoid cooperate to promote formation of anterior neural tissue by protecting, as early as blastula stage, presumptive anterior neural cells from an irreversible caudalization by the posteriorizing factor Wnt8a (show WNT8A ELISA Kits).
Gsc has dose dependent effects on axis induction and provide new insights into molecularly distinct short- and long-range signaling activities of the organizer.
5 genomic variants in GSC, HOXA2 (show HOXA2 ELISA Kits) and PRKRA (show PRKRA ELISA Kits) were identified through mutational analysis in Chinese patients with microtia.
GSC is also a prognostic factor for poor survival and metastasis of HCC (show FAM126A ELISA Kits), which suggests its potential as a therapeutic target for metastatic HCC (show FAM126A ELISA Kits).
Results suggest that GSC is the most potential biomarker of drug response and poor prognosis in ovarian serous carcinomas.
EtOH exposure increased the expression of an organizer specific gene, goosecoid, in human embryonic carcinoma cells.
SAMS (show MAT1A ELISA Kits), a syndrome of short stature, auditory-canal atresia, mandibular hypoplasia, and skeletal abnormalities is a unique neurocristopathy caused by mutations in Goosecoid.
GSC represses EVX1 expression and is required for development of anterior primitive-streak-like cell progeny in response to activin (show Actbeta ELISA Kits).
the 4 recently reported SNPs,located near BNC2, SORCS1 (show SORCS1 ELISA Kits), GSC and WDR72 loci, affecting glycemic control in type 1 diabetes had no apparent effect on HbA1c in type 2 diabetes; but, for SORCS1 (show SORCS1 ELISA Kits) SNP, findings do not rule out possible relationship with HbA1c
The goosecoid gene mutation in exon 3 may be involved in the malformation events (microtia) in this family.
Goosecoid promotes tumor cell malignancy and suggest that other conserved organizer genes may function similarly in human cancer
GSC protein might contribute to the observed phenotype.
Studies demonstrate that Wwp2 (show WWP2 ELISA Kits) influences craniofacial patterning through its interactions with Goosecoid (Gsc).
Role of gsc in mouse embryogenesis
TFII-I (show GTF2I ELISA Kits) has a role in the regulation of the Gsc gene in response to a TGFbeta (show TGFB1 ELISA Kits)/activin (show Actbeta ELISA Kits) signal
As Gsc is itself induced in a Foxh1 (show FOXH1 ELISA Kits)-dependent manner, we propose that Foxh1 (show FOXH1 ELISA Kits) initiates positive and negative transcriptional circuits to refine cell fate decisions during gastrulation
These data suggests that regulation of Gsc repressive activity by SUMO modification is promoter specific and may serve to differentially regulate genes that function to control cell morphology during early development and cancer.
Regulatory expression of Goosecoid in P19 embryonal carcinoma cells.
This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis.
, muenster 72
, goosecoid homeobox
, homeobox protein goosecoid
, zK49F1.1.2 (goosecoid)
, Homeobox protein goosecoid