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The protein encoded by GRHL2 is a transcription factor that can act as a homodimer or as a heterodimer with either GRHL1 or GRHL3. Additionally we are shipping GRHL2 Antibodies (30) and GRHL2 Proteins (5) and many more products for this protein.
Taken together, our results demonstrate a role for miR (show MLXIP ELISA Kits)-217 in the regulation of keratinocyte differentiation, partially through the regulation of GRHL2.
Genetic variations in the EYA4, GRHL2 and DFNA5 genes and their interactions with occupational noise exposure may play an important role in the incidence of noise-induced hearing loss (NIHL).
GRHL1 (show GRHL1 ELISA Kits), GRHL2, and GRHL3 (show GRHL3 ELISA Kits) have roles in cellular proliferation, differentiation, adhesion, and polarity and may promote cancer or be tumor suppressors [review]
The p63 (show RPE65 ELISA Kits) gene is regulated by GRHL2 through reciprocal feedback and determines the epithelial phenotype in human keratinocytes.
A Grhl2-dependent gene network controls trophoblast branching morphogenesis.
has identified ZEB1 (show ZEB1 ELISA Kits) as a target of GRHL2 and suggested a reciprocal GRHL2-ZEB1 (show ZEB1 ELISA Kits) repressive relationship, providing a novel mechanism through which proliferation may be modulated in colorectal cancer cells.
Mutations in GRHL2 result in an autosomal-recessive ectodermal Dysplasia syndrome.
Over-expression of Grhl2 decreased c-Myc (show MYC ELISA Kits) and Bcl-2 (show BCL2 ELISA Kits) protein expression level.
These findings indicate that GRHL2 may be a noise-induced hearing loss susceptibility gene and that polymorphisms of GRLH2 may contribute to the etiology of noise-induced hearing loss.
expression of GRHL2 is directly suppressed by the ZEB1 (show ZEB1 ELISA Kits), which in turn is a direct target for repression by GRHL2, suggesting that the EMT (show ITK ELISA Kits) transcription factors GRHL2 and ZEB1 (show ZEB1 ELISA Kits) form a double negative regulatory feedback loop
GRHL2 promotes the epithelial nature of non-neural ectoderm during dynamic events of neural tube formation by both activating key epithelial genes and actively suppressing epithelial-mesenchymal (EMT (show ITK ELISA Kits)) transition through novel downstream EMT (show ITK ELISA Kits) suppressors.
a Grhl2/Ovol2 network controls Cldn4 (show CLDN4 ELISA Kits) and Rab25 (show RAB25 ELISA Kits) expression that facilitates lumen expansion and barrier formation in subtypes of renal epithelia
Our findings reveal important pathophysiological differences between human pulmonary fibrosis and specific mouse models of fibrosis and support a crucial role of GRHL2 in epithelial activation in lung fibrosis and perhaps also in epithelial plasticity.
Grhl2 plays an essential role in the determination of epithelial phenotype of breast cancers, EMT (show ITK ELISA Kits) and tumor progression
the results indicate that Grhl2 regulates epithelial morphogenesis through transcriptional up-regulation of Cldn3 (show CLDN3 ELISA Kits) and Cldn4 (show CLDN4 ELISA Kits), as well as of Rab25 (show RAB25 ELISA Kits), which increases the Cldn4 (show CLDN4 ELISA Kits) protein and its localization at TJs
Grhl2 and Nkx2-1 (show NKX2-1 ELISA Kits) bind to each other's promoter in vivo, forming a positive feedback regulatory loop.
Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse
tissue closure defects in Grhl2 mutants are similar to that of AP-2alpha (show TFAP2A ELISA Kits) null mutants and AP-2alpha (show TFAP2A ELISA Kits) has been shown to bind to the promoter of E-cadherin (show CDH1 ELISA Kits)
Both GRHL2 and GRHL3 (show GRHL3 ELISA Kits) bind to and regulate expression of the wound repair gene Rho GEF (show ARHGEF2 ELISA Kits) 19, but regulation of the barrier forming gene, Transglutaminase 1 (TGase1 (show TGM1 ELISA Kits)), is unique to GRHL3 (show GRHL3 ELISA Kits).
The data showed that midbrain-hindbrain boundary maintenance and morphogenesis are dissociable events regulated by grhl2b through diverse transcriptional targets.
This work reveals an evolutionarily conserved function of Grhl2 in otic development and provides a fish model for further studying mechanisms of Grhl2-related hearing loss.
The protein encoded by this gene is a transcription factor that can act as a homodimer or as a heterodimer with either GRHL1 or GRHL3. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal dominant type 28 (DFNA28).
grainyhead-like 2 (Drosophila)
, transcription factor CP2-like 3
, brother of mammalian grainyhead
, grainyhead-like protein 2 homolog
, grainyhead like 2
, grainyhead-like 2
, grainyhead-like 2b protein