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Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Additionally we are shipping Granulin Kits (86) and Granulin Proteins (38) and many more products for this protein.
Showing 10 out of 153 products:
Human Polyclonal Granulin Primary Antibody for WB - ABIN1881391
Bhandari, Bateman: Structure and chromosomal location of the human granulin gene. in Biochemical and biophysical research communications 1992
Show all 3 references for ABIN1881391
Human Monoclonal Granulin Primary Antibody for IP, IHC - ABIN1169394
Ho, Ip, Cheung, Lee, Chan, Wong, Fan: Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma. in Hepatology (Baltimore, Md.) 2008
Show all 2 references for ABIN1169394
Mouse (Murine) Polyclonal Granulin Primary Antibody for ELISA - ABIN2000867
Trinh, Brown, Jeang: Epithelin/granulin growth factors: extracellular cofactors for HIV-1 and HIV-2 Tat proteins. in Biochemical and biophysical research communications 1999
Human Polyclonal Granulin Primary Antibody for ELISA, WB - ABIN561132
Bandey, Chiou, Huang, Tsai, Tu: Progranulin promotes Temozolomide resistance of glioblastoma by orchestrating DNA repair and tumor stemness. in Oncogene 2015
Human Polyclonal Granulin Primary Antibody for WB - ABIN375134
Ghetti, Spina, Murrell, Huey, Pietrini, Sweeney, Wassermann, Keohane, Farlow, Grafman: In vivo and postmortem clinicoanatomical correlations in frontotemporal dementia and parkinsonism linked to chromosome 17. in Neuro-degenerative diseases 2008
Human Polyclonal Granulin Primary Antibody for IF (p), IHC (p) - ABIN728668
Thurner, Fadle, Regitz, Kemele, Klemm, Zaks, Stöger, Bette, Carbon, Zimmer, Assmann, Murawski, Kubuschok, Held, Preuss, Pfreundschuh: The molecular basis for development of proinflammatory autoantibodies to progranulin. in Journal of autoimmunity 2015
the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes
GrnA positively modulates hepatic MET expression both in vivo and in vitro.
Studied levels of salivary visfatin (show NAMPT Antibodies), chemerin (show RARRES2 Antibodies), and progranulin and in gingivitis, periodontitis, as well as healthy patients. Salivary progranulin levels were similar in all groups; chemerin (show RARRES2 Antibodies) was detected at higher levels in the periodontitis group compared to the gingivitis and the healthy groups; visfatin (show NAMPT Antibodies) levels were higher in patients with gingivitis and periodontitis compared to those of healthy subjects.
Induction of PGRN expression may play a role in rheumatoid arthritis immune reaction and PGRN levels could be a useful biomarker in RA inflammatory response, but is not related with Breg cell levels.
Results indicate that CNS progranulin levels are regulated differently from peripheral progranulin levels in Alzheimer's dementia, frontotemporal dementia and amyotrophic lateral sclerosis
This study demonstrated that there appears to be a differential pattern of cerebellar atrophy in the major genetic forms of FTD (show FTL Antibodies), being relatively spared in GRN.
Data show that progranulin is upregulated in neuroendocrine tumors (NETs) and islets of the multiple endocrine neoplasia 1 (show MEN1 Antibodies) protein (MEN1 (show MEN1 Antibodies)) mouse as well as in the serum of patients with pancreatic NETs associated with glucagonoma syndrome.
data indicate that the described variants may cause a loss-of-function, albeit to a lesser extent than GRN null mutations, and hence could be considered as low-penetrant risk factors for neurodegenerative diseases
Progranulin is increased in lipodystrophy.
This study demonstrated that the GRN Thr272fs carriers of fronto-temporo-parietal damage.
Missense mutations in progranulin gene associated with frontotemporal lobar degeneration.
progranulin (PGRN), a protein targeted to the classical secretory pathway, is also secreted in association with exosomes by human primary fibroblasts and null mutations in the progranulin gene (GRN), a major cause of frontotemporal dementia, strongly reduce the number of released exosomes and alter their composition.
The results suggest that PGRN may affect the differentiation of retinal precursor cells to photoreceptor cells through the HGF receptor signaling pathway.
PGRN is overexpressed in the early stage of endotoxic shock in mice.
Deleting C1qa (show C1QA Antibodies) gene significantly reduces synaptic pruning by Grn(-/-) microglia and mitigates neurodegeneration, behavioral phenotypes, and premature mortality in Grn(-/-) mice; results uncover a previously unrecognized role of progranulin in suppressing aberrant microglia activation during aging.
CXCL9 (show CXCL9 Antibodies) expression is strongly upregulated in PGRN KO mice and its level is correlated with severity of inflammation in a dermatitis model.
Progranulin suppresses titanium particle induced inflammatory osteolysis by targeting TNFalpha (show TNF Antibodies) signaling.
Study concluded that core progranulin-mediated neurodegenerative phenotypes are penetrant on C57Bl/6 and 129/SvImJ mouse strains, but that genetic background modulates progranulin's role in neuroinflammation and hippocampal biology
Results suggest that PGRN is involved in the development and/or maturation of neuronal networks comprising Purkinje cells in the cerebellum, which may be a prerequisite to normal motor function
PGRN is a key regulator of insulin (show INS Antibodies) resistance and PGRN may mediate its effects, at least in part, by inducing ER stress via the PERK (show EIF2AK3 Antibodies)-eIF2alpha (show EIF2A Antibodies) dependent pathway
ADAM15 (show ADAM15 Antibodies) and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
, PC cell-derived growth factor