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anti-Granulin (GRN) Antibodies

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Additionally we are shipping Granulin Kits (106) and Granulin Proteins (38) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GRN 2896 P28799
GRN 29143 P23785
GRN 14824  
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Top anti-Granulin Antibodies at antibodies-online.com

Showing 10 out of 145 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human esophageal carcinoma labeled with Anti PGRN/Granulin Polyclonal Antibody,Unconjugated (ABIN728668) at 1:200 followed by conjugation to the secondary antibody and DAB staining. Formalin-fixed and paraffin embedded human esophageal carcinoma labeled with Anti PGRN Granulin Polyclonal Antibody, unconjugated (ABIN728668) at 1:200 followed by incubation with conjugated secondary antibody and DAB staining. 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Mouse Un-conjugated IP, IHC, ELISA, WB Immunoprecipitation of recombinant hProgranulin proteins using anti-Progranulin (human), mAb (PG359-7) . Recombinant hProgranulin Proteins were precipitated by PG359-7. The precipitated proteins were separated by SDS-PAGE, electroblotted, and visualized by Western blot/ECL reaction with rabbit anti-human Progranulin pAb. Western blot analysis using anti-Progranulin (human), mAb (PG359-7)  at 1:2,000 dilution. 1. Recombinant human Progranulin (FLAG ® -tagged). 2. Recombinant mouse Progranulin (FLAG ® -tagged) (Negative control). 3. Recombinant human GRN-C (FLAG ® -tagged). 4. Recombinant mouse Vaspin (FLAG ® -tagged) (Negative control). 100 μg Log in to see 5 to 8 Days
$309.75
Details
Human Rabbit Un-conjugated WB GRN Antibody (C-term) (ABIN1881391) western blot analysis in A2058,HepG2,HL-60,T47D cell line lysates (35 µg/lane). This demonstrates the GRN antibody detected the GRN protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Mouse Rabbit Un-conjugated ELISA 100 μg Log in to see 16 Days
$218.90
Details
Human Mouse Un-conjugated ELISA, WB GRN polyclonal antibody (A01), Lot # 061206JCSa Western Blot analysis of GRN expression in HepG2 . Western Blot detection against Immunogen (37.11 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Goat Un-conjugated ELISA, WB EB08934 (1µg/ml) staining of HeLa lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Goat Un-conjugated EIA, WB AP31954PU-N Granulin-3 antibody staining of A431 lysate at 1 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to GRN on HeLa cell (antibody concentration 10 µg/mL). GRN monoclonal antibody (M01), clone 1F5 Western Blot analysis of GRN expression in HeLa. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details

GRN Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Granulin Antibodies

  1. Human Polyclonal Granulin Primary Antibody for WB - ABIN1881391 : Bhandari, Bateman: Structure and chromosomal location of the human granulin gene. in Biochemical and biophysical research communications 1992 (PubMed)
    Show all 3 references for ABIN1881391

  2. Human Monoclonal Granulin Primary Antibody for IP, IHC - ABIN1169394 : Ho, Ip, Cheung, Lee, Chan, Wong, Fan: Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma. in Hepatology (Baltimore, Md.) 2008 (PubMed)
    Show all 2 references for ABIN1169394

  3. Human Polyclonal Granulin Primary Antibody for ELISA, WB - ABIN561132 : Bandey, Chiou, Huang, Tsai, Tu: Progranulin promotes Temozolomide resistance of glioblastoma by orchestrating DNA repair and tumor stemness. in Oncogene 2015 (PubMed)

  4. Mouse (Murine) Polyclonal Granulin Primary Antibody for ELISA - ABIN2000867 : Trinh, Brown, Jeang: Epithelin/granulin growth factors: extracellular cofactors for HIV-1 and HIV-2 Tat proteins. in Biochemical and biophysical research communications 1999 (PubMed)

  5. Human Polyclonal Granulin Primary Antibody for IF (p), IHC (p) - ABIN728668 : Thurner, Fadle, Regitz, Kemele, Klemm, Zaks, Stöger, Bette, Carbon, Zimmer, Assmann, Murawski, Kubuschok, Held, Preuss, Pfreundschuh: The molecular basis for development of proinflammatory autoantibodies to progranulin. in Journal of autoimmunity 2015 (PubMed)

  6. Human Polyclonal Granulin Primary Antibody for WB - ABIN375134 : Ghetti, Spina, Murrell, Huey, Pietrini, Sweeney, Wassermann, Keohane, Farlow, Grafman: In vivo and postmortem clinicoanatomical correlations in frontotemporal dementia and parkinsonism linked to chromosome 17. in Neuro-degenerative diseases 2008 (PubMed)

More Antibodies against Granulin Interaction Partners

Zebrafish Granulin (GRN) interaction partners

  1. the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes

  2. GrnA positively modulates hepatic MET expression both in vivo and in vitro.

Human Granulin (GRN) interaction partners

  1. Progranulin CSF (show CSF2 Antibodies) concentrations and CSF (show CSF2 Antibodies)/serum progranulin ratio were significantly higher in patients with infectious diseases, with disturbed BBB (show ALMS1 Antibodies) function and with elevated CSF (show CSF2 Antibodies) cell count and presence of oligoclonal bands.

  2. We investigated the effect of progranulin (PGRN) expression on the proliferation and senescence of cervical cancer cells

  3. Mutations in granulin are the genetic causes of frontotemporal lobar degeneration.

  4. GRN mutated FTD (show FTL Antibodies) patients were older at death and more likely to present with non-fluent aphasia. They had TDP-43 (show TARDBP Antibodies) pathology.

  5. PGRN-mediated stimulation of the PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies)-ERK1/2 (show MAPK1/3 Antibodies)/CDK4/6 (show CDK4 Antibodies)/pRb (show RB1 Antibodies) pathway

  6. In contrast with TBK1 (show TBK1 Antibodies) carriers, Belgian GRN carriers were more often diagnosed with the language variant than the behavioral variant in frontotemporal dementia patients.

  7. that progranulin could promote invasiveness of epithelial ovarian cancer cells through an epithelial mesenchymal transition program directly

  8. The study demonstrates increased PGRN expression at local sites of inflammation and association between PGRN levels, disease activity, and functional impairment in patients with Rheumatoid Arthritis.

  9. Data show that exclusive occurrence of pSer81 progranulin (PGRN) isoform in PGRN-antibody-positive patients.

  10. Progranulin overproduction due to Fli-1 (show FLI1 Antibodies) deficiency may contribute to the constitutive activation of SSc (show CYP11A1 Antibodies) dermal fibroblasts by antagonizing the antifibrotic effect of TNF (show TNF Antibodies).

Mouse (Murine) Granulin (GRN) interaction partners

  1. Study concluded that core progranulin-mediated neurodegenerative phenotypes are penetrant on C57Bl/6 and 129/SvImJ mouse strains, but that genetic background modulates progranulin's role in neuroinflammation and hippocampal biology

  2. Results suggest that PGRN is involved in the development and/or maturation of neuronal networks comprising Purkinje cells in the cerebellum, which may be a prerequisite to normal motor function

  3. PGRN is a key regulator of insulin (show INS Antibodies) resistance and PGRN may mediate its effects, at least in part, by inducing ER stress via the PERK (show EIF2AK3 Antibodies)-eIF2alpha (show EIF2A Antibodies) dependent pathway

  4. Progranulin overproduction due to Fli-1 (show FLI1 Antibodies) deficiency may contribute to the constitutive activation of SSc (show CYP11A1 Antibodies) dermal fibroblasts by antagonizing the antifibrotic effect of TNF (show TNF Antibodies).

  5. PGRN may play a critical role in homeostasis of IVD (show IVD Antibodies), and may serve as a potential molecular target for prevention and treatment of disc degenerative diseases.

  6. These data suggest that targeting activation of the alpha7 nAChR (show CHRNA7 Antibodies) pathway may be beneficial in decreasing neuroinflammation and reversing some of the behavioral deficits observed in progranulin-deficient frontotemporal dementia.

  7. Prosaposin (show PSAP Antibodies) facilitates sortilin (show SORT1 Antibodies)-independent lysosomal trafficking of progranulin.

  8. In conclusion, PGRN may be a promising treatment target for both atherosclerosis and inflammation-related osteoporosis.

  9. PGRN protects against colitis progression in mice in an IL-10 (show IL10 Antibodies) and TNFR2 (show TNFRSF1B Antibodies) dependent manner.

  10. progranulin may be a novel therapeutic target that provides vascular protection, anti-neuroinflammation, and neuroprotection

Guinea Pig Granulin (GRN) interaction partners

  1. ADAM15 (show ADAM15 Antibodies) and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.

Granulin (GRN) Antigen Profile

Protein Summary

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Gene names and symbols associated with anti-Granulin (GRN) Antibodies

  • granulin (GRN) antibody
  • granulin a (grna) antibody
  • Granulins (grn) antibody
  • granulin (grn) antibody
  • granulin (granulin) antibody
  • granulin (ORF1 granulin) antibody
  • granulin (Grn) antibody
  • acrogranin antibody
  • CLN11 antibody
  • DKFZp459H066 antibody
  • epithelin antibody
  • GEP antibody
  • GP88 antibody
  • grn antibody
  • MGC53354 antibody
  • PCDGF antibody
  • PEPI antibody
  • PGRN antibody
  • wu:fb11g12 antibody
  • wu:fj18f05 antibody

Protein level used designations for anti-Granulin (GRN) Antibodies

granulin , granulin-a , zfPGRN-A , Granulins , PC cell-derived growth factor , acrogranin , granulin-epithelin , granulins , proepithelin , progranulin , PCDGF , PEPI , acrogranulin

GENE ID SPECIES
454728 Pan troglodytes
100051035 Equus caballus
791524 Danio rerio
100195018 Salmo salar
380370 Xenopus laevis
1463344 Adoxophyes orana granulovirus
2776804 Agrotis segetum granulovirus
100173689 Pongo abelii
2896 Homo sapiens
29143 Rattus norvegicus
14824 Mus musculus
480501 Canis lupus familiaris
733645 Sus scrofa
767942 Bos taurus
100135533 Cavia porcellus
100349528 Oryctolagus cuniculus
101115470 Ovis aries
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