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Granulin Proteins (GRN)

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Additionally we are shipping Granulin Antibodies (151) and Granulin Kits (106) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GRN 2896 P28799
GRN 29143 P23785
GRN 14824  
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Top Granulin Proteins at antibodies-online.com

Showing 10 out of 38 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_HEK-293 Rat Un-conjugated 50 μg Log in to see 2 to 3 Days
$792.75
Details
HOST_HEK-293 Mouse Un-conjugated 50 μg Log in to see 2 to 3 Days
$792.75
Details
HOST_HEK-293 Mouse Un-conjugated 50 μg Log in to see 2 to 3 Days
$840.00
Details
HOST_HEK-293 Rat Un-conjugated 50 μg Log in to see 2 to 3 Days
$840.00
Details
HOST_HEK-293 Human Un-conjugated 50 μg Log in to see 2 to 3 Days
$840.00
Details
HOST_Human Rat DYKDDDDK Tag   10 μg Log in to see 5 to 8 Days
$231.00
Details
HOST_Escherichia coli (E. coli) Human His tag,S tag 100 μg Log in to see 11 to 13 Days
$492.80
Details

GRN Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , ,
Rat (Rattus) , ,
,
Mouse (Murine) , ,
,

Top referenced Granulin Proteins

  1. Human Granulin Protein expressed in Wheat germ - ABIN1355792 : Chen, Chang, Deng, Xu, Nguyen, Martens, Cenik, Taylor, Hudson, Chung, Yu, Yu, Herz, Farese, Kukar, Tansey: Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 (PubMed)
    Show all 3 references for ABIN1355792

More Proteins for Granulin (GRN) Interaction Partners

Zebrafish Granulin (GRN) interaction partners

  1. the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes

  2. GrnA positively modulates hepatic MET expression both in vivo and in vitro.

Human Granulin (GRN) interaction partners

  1. Progranulin CSF (show CSF2 Proteins) concentrations and CSF (show CSF2 Proteins)/serum progranulin ratio were significantly higher in patients with infectious diseases, with disturbed BBB function and with elevated CSF (show CSF2 Proteins) cell count and presence of oligoclonal bands.

  2. We investigated the effect of progranulin (PGRN) expression on the proliferation and senescence of cervical cancer cells

  3. Mutations in granulin are the genetic causes of frontotemporal lobar degeneration.

  4. GRN mutated FTD (show FTL Proteins) patients were older at death and more likely to present with non-fluent aphasia. They had TDP-43 (show TARDBP Proteins) pathology.

  5. PGRN-mediated stimulation of the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)-ERK1/2/CDK4/6 (show CDK4 Proteins)/pRb (show RB1 Proteins) pathway

  6. In contrast with TBK1 (show TBK1 Proteins) carriers, Belgian GRN carriers were more often diagnosed with the language variant than the behavioral variant in frontotemporal dementia patients.

  7. that progranulin could promote invasiveness of epithelial ovarian cancer cells through an epithelial mesenchymal transition program directly

  8. The study demonstrates increased PGRN expression at local sites of inflammation and association between PGRN levels, disease activity, and functional impairment in patients with Rheumatoid Arthritis.

  9. Data show that exclusive occurrence of pSer81 progranulin (PGRN) isoform in PGRN-antibody-positive patients.

  10. Progranulin overproduction due to Fli-1 (show FLI1 Proteins) deficiency may contribute to the constitutive activation of SSc (show CYP11A1 Proteins) dermal fibroblasts by antagonizing the antifibrotic effect of TNF (show TNF Proteins).

Mouse (Murine) Granulin (GRN) interaction partners

  1. Study concluded that core progranulin-mediated neurodegenerative phenotypes are penetrant on C57Bl/6 and 129/SvImJ mouse strains, but that genetic background modulates progranulin's role in neuroinflammation and hippocampal biology

  2. Results suggest that PGRN is involved in the development and/or maturation of neuronal networks comprising Purkinje cells in the cerebellum, which may be a prerequisite to normal motor function

  3. PGRN is a key regulator of insulin (show INS Proteins) resistance and PGRN may mediate its effects, at least in part, by inducing ER stress via the PERK (show EIF2AK3 Proteins)-eIF2alpha (show EIF2A Proteins) dependent pathway

  4. Progranulin overproduction due to Fli-1 (show FLI1 Proteins) deficiency may contribute to the constitutive activation of SSc (show CYP11A1 Proteins) dermal fibroblasts by antagonizing the antifibrotic effect of TNF (show TNF Proteins).

  5. PGRN may play a critical role in homeostasis of IVD (show IVD Proteins), and may serve as a potential molecular target for prevention and treatment of disc degenerative diseases.

  6. These data suggest that targeting activation of the alpha7 nAChR (show CHRNA7 Proteins) pathway may be beneficial in decreasing neuroinflammation and reversing some of the behavioral deficits observed in progranulin-deficient frontotemporal dementia.

  7. Prosaposin (show PSAP Proteins) facilitates sortilin (show SORT1 Proteins)-independent lysosomal trafficking of progranulin.

  8. In conclusion, PGRN may be a promising treatment target for both atherosclerosis and inflammation-related osteoporosis.

  9. PGRN protects against colitis progression in mice in an IL-10 (show IL10 Proteins) and TNFR2 (show TNFRSF1B Proteins) dependent manner.

  10. progranulin may be a novel therapeutic target that provides vascular protection, anti-neuroinflammation, and neuroprotection

Guinea Pig Granulin (GRN) interaction partners

  1. ADAM15 (show ADAM15 Proteins) and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.

Granulin (GRN) Protein Profile

Protein Summary

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Gene names and symbols associated with Granulin Proteins (GRN)

  • granulin (GRN)
  • granulin a (grna)
  • Granulins (grn)
  • granulin (grn)
  • granulin (granulin)
  • granulin (ORF1 granulin)
  • granulin (Grn)
  • acrogranin protein
  • CLN11 protein
  • DKFZp459H066 protein
  • epithelin protein
  • GEP protein
  • GP88 protein
  • grn protein
  • MGC53354 protein
  • PCDGF protein
  • PEPI protein
  • PGRN protein
  • wu:fb11g12 protein
  • wu:fj18f05 protein

Protein level used designations for Granulin Proteins (GRN)

granulin , granulin-a , zfPGRN-A , Granulins , PC cell-derived growth factor , acrogranin , granulin-epithelin , granulins , proepithelin , progranulin , PCDGF , PEPI , acrogranulin

GENE ID SPECIES
454728 Pan troglodytes
100051035 Equus caballus
791524 Danio rerio
100195018 Salmo salar
380370 Xenopus laevis
1463344 Adoxophyes orana granulovirus
2776804 Agrotis segetum granulovirus
100173689 Pongo abelii
2896 Homo sapiens
29143 Rattus norvegicus
14824 Mus musculus
480501 Canis lupus familiaris
733645 Sus scrofa
767942 Bos taurus
100135533 Cavia porcellus
100349528 Oryctolagus cuniculus
101115470 Ovis aries
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