anti-Granulin (GRN) Antibodies

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Additionally we are shipping Granulin Kits (108) and Granulin Proteins (45) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GRN 2896 P28799
GRN 29143 P23785
GRN 14824  
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Top anti-Granulin Antibodies at antibodies-online.com

Showing 10 out of 159 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human esophageal carcinoma labeled with Anti PGRN/Granulin Polyclonal Antibody,Unconjugated (ABIN728668) at 1:200 followed by conjugation to the secondary antibody and DAB staining. Formalin-fixed and paraffin embedded human esophageal carcinoma labeled with Anti PGRN Granulin Polyclonal Antibody, unconjugated (ABIN728668) at 1:200 followed by incubation with conjugated secondary antibody and DAB staining. 100 μL Log in to see 3 to 7 Days
$307.45
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: Granulin Antibody [NBP1-32076] - Rat tissue extract (50 ug) was separated by 7.5% SDS-PAGE, and the membrane was blotted with Granulins antibody diluted at 1:1000. Western Blot: Granulin Antibody [NBP1-32076] - Sample (30 ug of whole cell lysate) A: HepG2 7. 5% SDS PAGE; antibody diluted at 1:1000. 0.1 mL Log in to see 7 to 9 Days
$447.56
Details
Mouse Rabbit Un-conjugated ELISA, IHC (p) 100 μg Log in to see 20 to 21 Days
$218.90
Details
Human Rabbit Un-conjugated WB GRN Antibody (C-term) (ABIN1881391) western blot analysis in A2058,HepG2,HL-60,T47D cell line lysates (35 µg/lane). This demonstrates the GRN antibody detected the GRN protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated IP, IHC, ELISA, WB Immunoprecipitation of recombinant hProgranulin proteins using anti-Progranulin (human), mAb (PG359-7) . Recombinant hProgranulin Proteins were precipitated by PG359-7. The precipitated proteins were separated by SDS-PAGE, electroblotted, and visualized by Western blot/ECL reaction with rabbit anti-human Progranulin pAb. Western blot analysis using anti-Progranulin (human), mAb (PG359-7)  at 1:2,000 dilution. 1. Recombinant human Progranulin (FLAG ® -tagged). 2. Recombinant mouse Progranulin (FLAG ® -tagged) (Negative control). 3. Recombinant human GRN-C (FLAG ® -tagged). 4. Recombinant mouse Vaspin (FLAG ® -tagged) (Negative control). 100 μg Log in to see 5 to 8 Days
$330.75
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 7 to 9 Days
$408.19
Details
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunocytochemistry/Immunofluorescence: Granulin Antibody [NBP1-87325] Staining of human cell line U-251 MG shows positivity in vesicles. Immunohistochemistry-Paraffin: Granulin Antibody [NBP1-87325] - Staining of human duodenum shows strong cytoplasmic positivity in glandular cells. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: Granulin Antibody [NBP1-87324] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells).Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells) Immunocytochemistry/Immunofluorescence: Granulin Antibody [NBP1-87324] - Staining of human cell line A-431 shows positivity in vesicles. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$481.25
Details

GRN Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Granulin Antibodies

  1. Human Polyclonal Granulin Primary Antibody for WB - ABIN1881391 : Bhandari, Bateman: Structure and chromosomal location of the human granulin gene. in Biochemical and biophysical research communications 1992 (PubMed)
    Show all 3 references for 1881391

  2. Human Monoclonal Granulin Primary Antibody for IP, IHC - ABIN1169394 : Ho, Ip, Cheung, Lee, Chan, Wong, Fan: Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma. in Hepatology (Baltimore, Md.) 2008 (PubMed)
    Show all 2 references for 1169394

  3. Human Polyclonal Granulin Primary Antibody for ICC, IF - ABIN4315998 : Elkabets, Gifford, Scheel, Nilsson, Reinhardt, Bray, Carpenter, Jirström, Magnusson, Ebert, Pontén, Weinberg, McAllister: Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice. in The Journal of clinical investigation 2011 (PubMed)

  4. Mouse (Murine) Polyclonal Granulin Primary Antibody for ELISA, IHC (p) - ABIN2000867 : Trinh, Brown, Jeang: Epithelin/granulin growth factors: extracellular cofactors for HIV-1 and HIV-2 Tat proteins. in Biochemical and biophysical research communications 1999 (PubMed)

  5. Human Polyclonal Granulin Primary Antibody for ELISA, WB - ABIN439720 : Ghetti, Spina, Murrell, Huey, Pietrini, Sweeney, Wassermann, Keohane, Farlow, Grafman: In vivo and postmortem clinicoanatomical correlations in frontotemporal dementia and parkinsonism linked to chromosome 17. in Neuro-degenerative diseases 2008 (PubMed)

  6. Human Polyclonal Granulin Primary Antibody for ICC, IF - ABIN4315995 : Kahle, Gulbahce, Shaw, Lim, Hill, Barabási, Zoghbi: Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. in Human molecular genetics 2011 (PubMed)

  7. Human Polyclonal Granulin Primary Antibody for IF (p), IHC (p) - ABIN728668 : Thurner, Fadle, Regitz, Kemele, Klemm, Zaks, Stöger, Bette, Carbon, Zimmer, Assmann, Murawski, Kubuschok, Held, Preuss, Pfreundschuh: The molecular basis for development of proinflammatory autoantibodies to progranulin. in Journal of autoimmunity 2015 (PubMed)

More Antibodies against Granulin Interaction Partners

Zebrafish Granulin (GRN) interaction partners

  1. Findings show that miR (show MYLIP Antibodies)-145 and GrnA expression patterns are inversely correlated during liver development and provide evidence that GrnA-dependent hepatic outgrowth is regulated by miR (show MYLIP Antibodies)-145 in zebrafish embryonic development.

  2. the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes

  3. GrnA positively modulates hepatic MET expression both in vivo and in vitro.

Human Granulin (GRN) interaction partners

  1. Mutation of GRN is a common cause of FTD (show FTL Antibodies) in mainland China.

  2. the influence of the p.A152T MAPT (show MAPT Antibodies) variant on the clinical and neuropathological features of these Basque GRN families, is reported.

  3. Results indicate that central nervous progranulin reduction is not restricted to the relatively rare cases of frontotemporal dementia caused by progranulin gene (GRN) loss of function mutations, but also contributes to the more common GRN-negative forms of frontotemporal dementia.

  4. a complete screening for mutations in MAPT (show MAPT Antibodies), GRN and C9ORF72 (show C9ORF72 Antibodies) genes revealed a frequency of 5.4% of pathogenic mutations in a random cohort of 93 Turkish index patients with dementia

  5. This Progress article reviews recent advances in progranulin biology emphasizing its roles in lysosomal function and brain innate immunity, and outlines future avenues of investigation that may lead to new therapeutic approaches for neurodegeneration--{REVIEW}

  6. serum progranulin levels had a positive correlation with pulmonary function in patients with asthma and a negative correlation with blood neutrophil counts.

  7. Progranulin (PGRN), a 593-amino-acid autocrine growth factor has multiple functions involved in cell proliferation, wound healing, neurodegeneration, insulin (show INS Antibodies) resistance, and tumorigenesis.

  8. progranulin is affected by a decrease in eGFR (show EGFR Antibodies), being at a higher concentration in serum and lower in urine of DKD patients with T2DM and eGFR (show EGFR Antibodies) <60 mL/min/1.73m2. It is also associated with markers of obesity and inflammation

  9. EphA2 (show EPHA2 Antibodies), a member of the large family of Ephrin receptor tyrosine kinases, is a functional signaling receptor for progranulin.

  10. recruitment of granulin-expressing inflammatory monocytes plays a key role in Pancreatic ductal adenocarcinoma metastasis

Mouse (Murine) Granulin (GRN) interaction partners

  1. PGRN decrease, resulting from pathogenic mutations, might compromise the trophism of cortical neurons by affecting GluN2B (show GRIN2B Antibodies)-contaning NMDA receptors

  2. The PGRN is a nonredundant regulator of systemic inflammation via modulating the levels and activity of C/EBPalpha, IL-10, and the ubiquitin-proteasome proteolysis pathway.

  3. Grn and Tmem106b genes have opposite effects on lysosomal enzyme levels, and their interaction determines the extent of neurodegeneration

  4. PGRN induction of IL-10 (show IL10 Antibodies) in Treg cells depends on FOXO4 (show FOXO4 Antibodies) and Stat3 (show STAT3 Antibodies).

  5. ECM1 (show ECM1 Antibodies) seems to be critical for PTHrP (show PTHLH Antibodies) action in chondrogenesis, as blockage of ECM1 (show ECM1 Antibodies) nearly abolishes PTHrP (show PTHLH Antibodies) regulation of chondrocyte hypertrophy, and overexpression of ECM1 (show ECM1 Antibodies) rescues disorganized growth plates of PTHrP (show PTHLH Antibodies)-null mice; ECM1 (show ECM1 Antibodies) and progranulin chondrogenic growth factor constitute an interaction network.

  6. Knocking down receptor-interacting serine/threonine protein kinase 1 (Ripk1 (show RIPK1 Antibodies)) increased both intracellular and extracellular PGRN protein levels by increasing the translation rate of PGRN without affecting mRNA levels.

  7. In progranulin knockout mice, there was no estrogen receptor alpha (show ESR1 Antibodies) immunoreactivity in astrocytes in males or females at various ages. These results suggest that PGRN plays a crucial role in the expression of ERalpha (show ESR1 Antibodies) in astrocytes regardless of the estrous cycle stage, sex, and maturity.

  8. recruitment of granulin-expressing inflammatory monocytes plays a key role in Pancreatic ductal adenocarcinoma metastasis.

  9. Progranulin causes adipose insulin (show INS Antibodies) resistance via increased autophagy resulting from activated oxidative stress and endoplasmic reticulum stress.

  10. Grn+/- mice have biphasic social dominance associated with abnormal neuronal morphology and signaling. Grn-/- mice did not exhibit abnormal social dominance.

Guinea Pig Granulin (GRN) interaction partners

  1. ADAM15 (show ADAM15 Antibodies) and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.

Granulin (GRN) Antigen Profile

Protein Summary

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Gene names and symbols associated with anti-Granulin (GRN) Antibodies

  • granulin (GRN) antibody
  • granulin a (grna) antibody
  • Granulins (grn) antibody
  • granulin (grn) antibody
  • granulin (granulin) antibody
  • granulin (ORF1 granulin) antibody
  • granulin (Grn) antibody
  • acrogranin antibody
  • CLN11 antibody
  • DKFZp459H066 antibody
  • epithelin antibody
  • GEP antibody
  • GP88 antibody
  • grn antibody
  • MGC53354 antibody
  • PCDGF antibody
  • PEPI antibody
  • PGRN antibody
  • wu:fb11g12 antibody
  • wu:fj18f05 antibody

Protein level used designations for anti-Granulin (GRN) Antibodies

granulin , granulin-a , zfPGRN-A , Granulins , PC cell-derived growth factor , acrogranin , granulin-epithelin , granulins , proepithelin , progranulin , PCDGF , PEPI , acrogranulin

GENE ID SPECIES
454728 Pan troglodytes
100051035 Equus caballus
791524 Danio rerio
100195018 Salmo salar
380370 Xenopus laevis
1463344 Adoxophyes orana granulovirus
2776804 Agrotis segetum granulovirus
100173689 Pongo abelii
2896 Homo sapiens
29143 Rattus norvegicus
14824 Mus musculus
480501 Canis lupus familiaris
733645 Sus scrofa
767942 Bos taurus
100135533 Cavia porcellus
100349528 Oryctolagus cuniculus
101115470 Ovis aries
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