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Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Additionally we are shipping Granulin Kits (106) and Granulin Proteins (37) and many more products for this protein.
Showing 10 out of 156 products:
Human Polyclonal Granulin Primary Antibody for WB - ABIN1881391
Bhandari, Bateman: Structure and chromosomal location of the human granulin gene. in Biochemical and biophysical research communications 1992
Show all 3 references for ABIN1881391
Human Monoclonal Granulin Primary Antibody for IP, IHC - ABIN1169394
Ho, Ip, Cheung, Lee, Chan, Wong, Fan: Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma. in Hepatology (Baltimore, Md.) 2008
Show all 2 references for ABIN1169394
Human Polyclonal Granulin Primary Antibody for ICC, IF - ABIN4315998
Elkabets, Gifford, Scheel, Nilsson, Reinhardt, Bray, Carpenter, Jirström, Magnusson, Ebert, Pontén, Weinberg, McAllister: Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice. in The Journal of clinical investigation 2011
Human Polyclonal Granulin Primary Antibody for ELISA, WB - ABIN439720
Ghetti, Spina, Murrell, Huey, Pietrini, Sweeney, Wassermann, Keohane, Farlow, Grafman: In vivo and postmortem clinicoanatomical correlations in frontotemporal dementia and parkinsonism linked to chromosome 17. in Neuro-degenerative diseases 2008
Human Polyclonal Granulin Primary Antibody for IF (p), IHC (p) - ABIN728668
Thurner, Fadle, Regitz, Kemele, Klemm, Zaks, Stöger, Bette, Carbon, Zimmer, Assmann, Murawski, Kubuschok, Held, Preuss, Pfreundschuh: The molecular basis for development of proinflammatory autoantibodies to progranulin. in Journal of autoimmunity 2015
Human Polyclonal Granulin Primary Antibody for ICC, IF - ABIN4315995
Kahle, Gulbahce, Shaw, Lim, Hill, Barabási, Zoghbi: Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. in Human molecular genetics 2011
Mouse (Murine) Polyclonal Granulin Primary Antibody for ELISA, IHC (p) - ABIN2000867
Trinh, Brown, Jeang: Epithelin/granulin growth factors: extracellular cofactors for HIV-1 and HIV-2 Tat proteins. in Biochemical and biophysical research communications 1999
the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes
GrnA positively modulates hepatic MET expression both in vivo and in vitro.
progranulin is affected by a decrease in eGFR (show EGFR Antibodies), being at a higher concentration in serum and lower in urine of DKD patients with T2DM and eGFR (show EGFR Antibodies) <60 mL/min/1.73m2. It is also associated with markers of obesity and inflammation
EphA2 (show EPHA2 Antibodies), a member of the large family of Ephrin receptor tyrosine kinases, is a functional signaling receptor for progranulin.
recruitment of granulin-expressing inflammatory monocytes plays a key role in Pancreatic ductal adenocarcinoma metastasis
PGRN expression might help predict treatment outcomes and provide a new target for molecular therapy
Secreted PGRN is incorporated into cells via sortilin (show SORT1 Antibodies) or cation-independent mannose 6-phosphate receptor (show IGF2R Antibodies), and facilitated the acidification of lysosomes and degradation of CTSDmat. Moreover, the change of PGRN levels led to a cell-type-specific increase of insoluble TDP-43 (show TARDBP Antibodies). In the brain tissue of FTLD-TDP patients with PGRN deficiency, CTSD (show CTSD Antibodies) and phosphorylated TDP-43 (show TARDBP Antibodies) accumulated in neurons
High progranulin expression is associated with Overweight/obese.
human and rodent data suggest that global PGRN reduction induces microglial TYROBP (show TYROBP Antibodies) network genes expression
The overexpression of miR588 in lung squamous cell carcinoma cells reduced the mRNA and protein levels of progranulin (GRN), whereas miR588 silencing increased the expression of GRN.
PGRN is upregulated in psoriasis lesions and the overexpression of PGRN inhibits the inflammation in keratinocytes induced by TNF-alpha (show TNF Antibodies) by negatively regulating the production of inflammatory factors and positively mediating autophagy through the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway
PGRN may have great potential as a diagnostic factor for active lupus nephritis and as a predictor for its disease activity.
Knocking down receptor-interacting serine/threonine protein kinase 1 (Ripk1 (show RIPK1 Antibodies)) increased both intracellular and extracellular PGRN protein levels by increasing the translation rate of PGRN without affecting mRNA levels.
In progranulin knockout mice, there was no estrogen receptor alpha (show ESR1 Antibodies) immunoreactivity in astrocytes in males or females at various ages. These results suggest that PGRN plays a crucial role in the expression of ERalpha (show ESR1 Antibodies) in astrocytes regardless of the estrous cycle stage, sex, and maturity.
recruitment of granulin-expressing inflammatory monocytes plays a key role in Pancreatic ductal adenocarcinoma metastasis.
Progranulin causes adipose insulin (show INS Antibodies) resistance via increased autophagy resulting from activated oxidative stress and endoplasmic reticulum stress.
Grn+/- mice have biphasic social dominance associated with abnormal neuronal morphology and signaling. Grn-/- mice did not exhibit abnormal social dominance.
this study shows that PGRN deficiency results in kidney injury, inflammatory cell infiltration, production of pro-inflammatory mediators, while administration of recombinant PGRN ameliorates endotoxin-induced acute kidney injury
Our data demonstrates an unknown association between PGRN and GD and identifies PGRN as an essential factor for GCase's lysosomal localization. These findings not only provide new insight into the pathogenesis of GD, but may also have implications for diagnosis and alternative targeted therapies for GD.
These findings not only demonstrate that PGRN is a co-chaperone of HSP70 (show HSP70 Antibodies) and plays an important role in GCase (show GBA Antibodies) lysosomal localization, but may also provide new therapeutic interventions for lysosomal storage diseases, in particular GD.
The results suggest that PGRN may affect the differentiation of retinal precursor cells to photoreceptor cells through the HGF receptor signaling pathway.
ADAM15 (show ADAM15 Antibodies) and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
, PC cell-derived growth factor