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Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Additionally we are shipping Granulin Kits (103) and Granulin Proteins (38) and many more products for this protein.
Showing 10 out of 155 products:
Human Polyclonal Granulin Primary Antibody for WB - ABIN1881391
Bhandari, Bateman: Structure and chromosomal location of the human granulin gene. in Biochemical and biophysical research communications 1992
Show all 3 references for ABIN1881391
Human Monoclonal Granulin Primary Antibody for IP, IHC - ABIN1169394
Ho, Ip, Cheung, Lee, Chan, Wong, Fan: Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma. in Hepatology (Baltimore, Md.) 2008
Show all 2 references for ABIN1169394
Human Polyclonal Granulin Primary Antibody for ICC, IF - ABIN4315997
Elkabets, Gifford, Scheel, Nilsson, Reinhardt, Bray, Carpenter, Jirström, Magnusson, Ebert, Pontén, Weinberg, McAllister: Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice. in The Journal of clinical investigation 2011
Mouse (Murine) Polyclonal Granulin Primary Antibody for ELISA - ABIN2000867
Trinh, Brown, Jeang: Epithelin/granulin growth factors: extracellular cofactors for HIV-1 and HIV-2 Tat proteins. in Biochemical and biophysical research communications 1999
Human Polyclonal Granulin Primary Antibody for ELISA, WB - ABIN439720
Ghetti, Spina, Murrell, Huey, Pietrini, Sweeney, Wassermann, Keohane, Farlow, Grafman: In vivo and postmortem clinicoanatomical correlations in frontotemporal dementia and parkinsonism linked to chromosome 17. in Neuro-degenerative diseases 2008
Human Polyclonal Granulin Primary Antibody for ICC, IF - ABIN4315995
Kahle, Gulbahce, Shaw, Lim, Hill, Barabási, Zoghbi: Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. in Human molecular genetics 2011
Human Polyclonal Granulin Primary Antibody for IF (p), IHC (p) - ABIN728668
Thurner, Fadle, Regitz, Kemele, Klemm, Zaks, Stöger, Bette, Carbon, Zimmer, Assmann, Murawski, Kubuschok, Held, Preuss, Pfreundschuh: The molecular basis for development of proinflammatory autoantibodies to progranulin. in Journal of autoimmunity 2015
the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes
GrnA positively modulates hepatic MET expression both in vivo and in vitro.
human and rodent data suggest that global PGRN reduction induces microglial TYROBP (show TYROBP Antibodies) network genes expression
The overexpression of miR588 in lung squamous cell carcinoma cells reduced the mRNA and protein levels of progranulin (GRN), whereas miR588 silencing increased the expression of GRN.
PGRN is upregulated in psoriasis lesions and the overexpression of PGRN inhibits the inflammation in keratinocytes induced by TNF-alpha (show TNF Antibodies) by negatively regulating the production of inflammatory factors and positively mediating autophagy through the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway
PGRN may have great potential as a diagnostic factor for active lupus nephritis and as a predictor for its disease activity.
GRN rs5458 may decrease the risk of PD in Chinese individuals.
Our report extends the evidence for genetic and phenotypic variability in frontotemporal lobar degeneration (FTLD) disorders, and detects a novel pathogenic GRN mutation, carriers of which could eventually help to evaluate the efficacy of different treatments at early stages of dementia
Results support further examination of PGRN as a potential marker in neurodegenerative diseases, since PGRN is stable in serum and CSF (show CSF2 Antibodies) and can be measured using ELISA kits from several providers
Our data demonstrates an unknown association between PGRN and GD and identifies PGRN as an essential factor for GCase's lysosomal localization. These findings not only provide new insight into the pathogenesis of GD, but may also have implications for diagnosis and alternative targeted therapies for GD.
Studied levels of salivary visfatin (show NAMPT Antibodies), chemerin (show RARRES2 Antibodies), and progranulin and in gingivitis, periodontitis, as well as healthy patients. Salivary progranulin levels were similar in all groups; chemerin (show RARRES2 Antibodies) was detected at higher levels in the periodontitis group compared to the gingivitis and the healthy groups; visfatin (show NAMPT Antibodies) levels were higher in patients with gingivitis and periodontitis compared to those of healthy subjects.
Induction of PGRN expression may play a role in rheumatoid arthritis immune reaction and PGRN levels could be a useful biomarker in RA inflammatory response, but is not related with Breg cell levels.
this study shows that PGRN deficiency results in kidney injury, inflammatory cell infiltration, production of pro-inflammatory mediators, while administration of recombinant PGRN ameliorates endotoxin-induced acute kidney injury
These findings not only demonstrate that PGRN is a co-chaperone of HSP70 (show HSP70 Antibodies) and plays an important role in GCase (show GBA Antibodies) lysosomal localization, but may also provide new therapeutic interventions for lysosomal storage diseases, in particular GD.
The results suggest that PGRN may affect the differentiation of retinal precursor cells to photoreceptor cells through the HGF receptor signaling pathway.
PGRN is overexpressed in the early stage of endotoxic shock in mice.
Deleting C1qa (show C1QA Antibodies) gene significantly reduces synaptic pruning by Grn(-/-) microglia and mitigates neurodegeneration, behavioral phenotypes, and premature mortality in Grn(-/-) mice; results uncover a previously unrecognized role of progranulin in suppressing aberrant microglia activation during aging.
CXCL9 (show CXCL9 Antibodies) expression is strongly upregulated in PGRN KO mice and its level is correlated with severity of inflammation in a dermatitis model.
Progranulin suppresses titanium particle induced inflammatory osteolysis by targeting TNFalpha (show TNF Antibodies) signaling.
Data show that progranulin is upregulated in neuroendocrine tumors (NETs) and islets of the multiple endocrine neoplasia 1 (show MEN1 Antibodies) protein (MEN1 (show MEN1 Antibodies)) mouse as well as in the serum of patients with pancreatic NETs associated with glucagonoma syndrome.
ADAM15 (show ADAM15 Antibodies) and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
, PC cell-derived growth factor