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anti-Granulin (GRN) Antibodies

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Additionally we are shipping Granulin Kits (106) and Granulin Proteins (37) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GRN 2896 P28799
GRN 29143 P23785
GRN 14824  
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Top anti-Granulin Antibodies at antibodies-online.com

Showing 10 out of 156 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human esophageal carcinoma labeled with Anti PGRN/Granulin Polyclonal Antibody,Unconjugated (ABIN728668) at 1:200 followed by conjugation to the secondary antibody and DAB staining. Formalin-fixed and paraffin embedded human esophageal carcinoma labeled with Anti PGRN Granulin Polyclonal Antibody, unconjugated (ABIN728668) at 1:200 followed by incubation with conjugated secondary antibody and DAB staining. 100 μL Log in to see 3 to 7 Days
$307.45
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: Granulin Antibody [NBP1-32076] - Rat tissue extract (50 ug) was separated by 7.5% SDS-PAGE, and the membrane was blotted with Granulins antibody diluted at 1:1000. Western Blot: Granulin Antibody [NBP1-32076] - Sample (30 ug of whole cell lysate) A: HepG2 7. 5% SDS PAGE; antibody diluted at 1:1000. 0.1 mL Log in to see 7 to 9 Days
$447.56
Details
Mouse Rabbit Un-conjugated ELISA, IHC (p) 100 μg Log in to see 20 to 21 Days
$218.90
Details
Human Rabbit Un-conjugated WB GRN Antibody (C-term) (ABIN1881391) western blot analysis in A2058,HepG2,HL-60,T47D cell line lysates (35 µg/lane). This demonstrates the GRN antibody detected the GRN protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated IP, IHC, ELISA, WB Immunoprecipitation of recombinant hProgranulin proteins using anti-Progranulin (human), mAb (PG359-7) . Recombinant hProgranulin Proteins were precipitated by PG359-7. The precipitated proteins were separated by SDS-PAGE, electroblotted, and visualized by Western blot/ECL reaction with rabbit anti-human Progranulin pAb. Western blot analysis using anti-Progranulin (human), mAb (PG359-7)  at 1:2,000 dilution. 1. Recombinant human Progranulin (FLAG ® -tagged). 2. Recombinant mouse Progranulin (FLAG ® -tagged) (Negative control). 3. Recombinant human GRN-C (FLAG ® -tagged). 4. Recombinant mouse Vaspin (FLAG ® -tagged) (Negative control). 100 μg Log in to see 5 to 8 Days
$330.75
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 7 to 9 Days
$408.19
Details
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunocytochemistry/Immunofluorescence: Granulin Antibody [NBP1-87325] Staining of human cell line U-251 MG shows positivity in vesicles. Immunohistochemistry-Paraffin: Granulin Antibody [NBP1-87325] - Staining of human duodenum shows strong cytoplasmic positivity in glandular cells. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: Granulin Antibody [NBP1-87324] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells).Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells) Immunocytochemistry/Immunofluorescence: Granulin Antibody [NBP1-87324] - Staining of human cell line A-431 shows positivity in vesicles. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details

GRN Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Granulin Antibodies

  1. Human Polyclonal Granulin Primary Antibody for WB - ABIN1881391 : Bhandari, Bateman: Structure and chromosomal location of the human granulin gene. in Biochemical and biophysical research communications 1992 (PubMed)
    Show all 3 references for ABIN1881391

  2. Human Monoclonal Granulin Primary Antibody for IP, IHC - ABIN1169394 : Ho, Ip, Cheung, Lee, Chan, Wong, Fan: Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma. in Hepatology (Baltimore, Md.) 2008 (PubMed)
    Show all 2 references for ABIN1169394

  3. Human Polyclonal Granulin Primary Antibody for ICC, IF - ABIN4315998 : Elkabets, Gifford, Scheel, Nilsson, Reinhardt, Bray, Carpenter, Jirström, Magnusson, Ebert, Pontén, Weinberg, McAllister: Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice. in The Journal of clinical investigation 2011 (PubMed)

  4. Human Polyclonal Granulin Primary Antibody for ELISA, WB - ABIN439720 : Ghetti, Spina, Murrell, Huey, Pietrini, Sweeney, Wassermann, Keohane, Farlow, Grafman: In vivo and postmortem clinicoanatomical correlations in frontotemporal dementia and parkinsonism linked to chromosome 17. in Neuro-degenerative diseases 2008 (PubMed)

  5. Human Polyclonal Granulin Primary Antibody for IF (p), IHC (p) - ABIN728668 : Thurner, Fadle, Regitz, Kemele, Klemm, Zaks, Stöger, Bette, Carbon, Zimmer, Assmann, Murawski, Kubuschok, Held, Preuss, Pfreundschuh: The molecular basis for development of proinflammatory autoantibodies to progranulin. in Journal of autoimmunity 2015 (PubMed)

  6. Human Polyclonal Granulin Primary Antibody for ICC, IF - ABIN4315995 : Kahle, Gulbahce, Shaw, Lim, Hill, Barabási, Zoghbi: Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. in Human molecular genetics 2011 (PubMed)

  7. Mouse (Murine) Polyclonal Granulin Primary Antibody for ELISA, IHC (p) - ABIN2000867 : Trinh, Brown, Jeang: Epithelin/granulin growth factors: extracellular cofactors for HIV-1 and HIV-2 Tat proteins. in Biochemical and biophysical research communications 1999 (PubMed)

More Antibodies against Granulin Interaction Partners

Zebrafish Granulin (GRN) interaction partners

  1. the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes

  2. GrnA positively modulates hepatic MET expression both in vivo and in vitro.

Human Granulin (GRN) interaction partners

  1. progranulin is affected by a decrease in eGFR (show EGFR Antibodies), being at a higher concentration in serum and lower in urine of DKD patients with T2DM and eGFR (show EGFR Antibodies) <60 mL/min/1.73m2. It is also associated with markers of obesity and inflammation

  2. EphA2 (show EPHA2 Antibodies), a member of the large family of Ephrin receptor tyrosine kinases, is a functional signaling receptor for progranulin.

  3. recruitment of granulin-expressing inflammatory monocytes plays a key role in Pancreatic ductal adenocarcinoma metastasis

  4. PGRN expression might help predict treatment outcomes and provide a new target for molecular therapy

  5. Secreted PGRN is incorporated into cells via sortilin (show SORT1 Antibodies) or cation-independent mannose 6-phosphate receptor (show IGF2R Antibodies), and facilitated the acidification of lysosomes and degradation of CTSDmat. Moreover, the change of PGRN levels led to a cell-type-specific increase of insoluble TDP-43 (show TARDBP Antibodies). In the brain tissue of FTLD-TDP patients with PGRN deficiency, CTSD (show CTSD Antibodies) and phosphorylated TDP-43 (show TARDBP Antibodies) accumulated in neurons

  6. High progranulin expression is associated with Overweight/obese.

  7. human and rodent data suggest that global PGRN reduction induces microglial TYROBP (show TYROBP Antibodies) network genes expression

  8. The overexpression of miR588 in lung squamous cell carcinoma cells reduced the mRNA and protein levels of progranulin (GRN), whereas miR588 silencing increased the expression of GRN.

  9. PGRN is upregulated in psoriasis lesions and the overexpression of PGRN inhibits the inflammation in keratinocytes induced by TNF-alpha (show TNF Antibodies) by negatively regulating the production of inflammatory factors and positively mediating autophagy through the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway

  10. PGRN may have great potential as a diagnostic factor for active lupus nephritis and as a predictor for its disease activity.

Mouse (Murine) Granulin (GRN) interaction partners

  1. Knocking down receptor-interacting serine/threonine protein kinase 1 (Ripk1 (show RIPK1 Antibodies)) increased both intracellular and extracellular PGRN protein levels by increasing the translation rate of PGRN without affecting mRNA levels.

  2. In progranulin knockout mice, there was no estrogen receptor alpha (show ESR1 Antibodies) immunoreactivity in astrocytes in males or females at various ages. These results suggest that PGRN plays a crucial role in the expression of ERalpha (show ESR1 Antibodies) in astrocytes regardless of the estrous cycle stage, sex, and maturity.

  3. recruitment of granulin-expressing inflammatory monocytes plays a key role in Pancreatic ductal adenocarcinoma metastasis.

  4. Progranulin causes adipose insulin (show INS Antibodies) resistance via increased autophagy resulting from activated oxidative stress and endoplasmic reticulum stress.

  5. Grn+/- mice have biphasic social dominance associated with abnormal neuronal morphology and signaling. Grn-/- mice did not exhibit abnormal social dominance.

  6. human and rodent data suggest that global PGRN reduction induces microglial TYROBP (show TYROBP Antibodies) network genes expression

  7. this study shows that PGRN deficiency results in kidney injury, inflammatory cell infiltration, production of pro-inflammatory mediators, while administration of recombinant PGRN ameliorates endotoxin-induced acute kidney injury

  8. Our data demonstrates an unknown association between PGRN and GD and identifies PGRN as an essential factor for GCase's lysosomal localization. These findings not only provide new insight into the pathogenesis of GD, but may also have implications for diagnosis and alternative targeted therapies for GD.

  9. These findings not only demonstrate that PGRN is a co-chaperone of HSP70 (show HSP70 Antibodies) and plays an important role in GCase (show GBA Antibodies) lysosomal localization, but may also provide new therapeutic interventions for lysosomal storage diseases, in particular GD.

  10. The results suggest that PGRN may affect the differentiation of retinal precursor cells to photoreceptor cells through the HGF receptor signaling pathway.

Guinea Pig Granulin (GRN) interaction partners

  1. ADAM15 (show ADAM15 Antibodies) and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.

Granulin (GRN) Antigen Profile

Protein Summary

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Gene names and symbols associated with anti-Granulin (GRN) Antibodies

  • granulin (GRN) antibody
  • granulin a (grna) antibody
  • Granulins (grn) antibody
  • granulin (grn) antibody
  • granulin (granulin) antibody
  • granulin (ORF1 granulin) antibody
  • granulin (Grn) antibody
  • acrogranin antibody
  • CLN11 antibody
  • DKFZp459H066 antibody
  • epithelin antibody
  • GEP antibody
  • GP88 antibody
  • grn antibody
  • MGC53354 antibody
  • PCDGF antibody
  • PEPI antibody
  • PGRN antibody
  • wu:fb11g12 antibody
  • wu:fj18f05 antibody

Protein level used designations for anti-Granulin (GRN) Antibodies

granulin , granulin-a , zfPGRN-A , Granulins , PC cell-derived growth factor , acrogranin , granulin-epithelin , granulins , proepithelin , progranulin , PCDGF , PEPI , acrogranulin

GENE ID SPECIES
454728 Pan troglodytes
100051035 Equus caballus
791524 Danio rerio
100195018 Salmo salar
380370 Xenopus laevis
1463344 Adoxophyes orana granulovirus
2776804 Agrotis segetum granulovirus
100173689 Pongo abelii
2896 Homo sapiens
29143 Rattus norvegicus
14824 Mus musculus
480501 Canis lupus familiaris
733645 Sus scrofa
767942 Bos taurus
100135533 Cavia porcellus
100349528 Oryctolagus cuniculus
101115470 Ovis aries
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