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Granulin (GRN) ELISA Kits

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Additionally we are shipping Granulin Antibodies (156) and Granulin Proteins (37) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
GRN 2896 P28799
GRN 29143 P23785
GRN 14824  
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Top Granulin ELISA Kits at antibodies-online.com

Showing 10 out of 106 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 50pg/mL 1.56-100 ng/mL Human Progranulin PicoKine ELISA Kit standard curve 96 Tests Log in to see 4 to 6 Days
$369.00
Details
Mouse 10pg/mL 0.78-50 ng/mL Mouse Progranulin PicoKine ELISA Kit standard curve 96 Tests Log in to see 4 to 6 Days
$369.00
Details
Rat 0.065 ng/mL 0.15-10 ng/mL 96 Tests Log in to see 13 to 16 Days
$640.00
Details
Guinea Pig 1.0 pg/mL 50-1000 pg/mL   96 Tests Log in to see 11 to 13 Days
$707.14
Details
Rabbit 1.0 pg/mL 50-1000 pg/mL   96 Tests Log in to see 11 to 13 Days
$707.14
Details
Chicken 1.875 ng/mL 3.125-200 ng/mL   96 Tests Log in to see 8 to 9 Days
$715.00
Details
Pig 0.938 ng/mL 1.563-100 ng/mL   96 Tests Log in to see 8 to 9 Days
$715.00
Details
Monkey 1.0 pg/mL 250-5000 pg/mL   96 Tests Log in to see 11 to 13 Days
$707.14
Details
Dog 1.0 pg/mL 50-1000 pg/mL   96 Tests Log in to see 11 to 13 Days
$707.14
Details
Sheep
  96 Tests Log in to see 11 to 13 Days
$707.14
Details

Top referenced Granulin ELISA Kits

  1. Human Granulin ELISA Kit for Sandwich ELISA - ABIN1672874 : Ahmed, Sheng, Xu, Lin, Innes, Gass, Yu, Wuertzer, Hou, Chiba, Yamanouchi, Leissring, Petrucelli, Nishihara, Hutton, McGowan, Dickson, Lewis: Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging. in The American journal of pathology 2010 (PubMed)
    Show all 2 references for ABIN1672874

  2. Mouse (Murine) Granulin ELISA Kit for Sandwich ELISA - ABIN1889363 : Kelley, Haidar, Boeve, Baker, Shiung, Knopman, Rademakers, Hutton, Adamson, Kuntz, Dickson, Parisi, Smith, Petersen: Alzheimer disease-like phenotype associated with the c.154delA mutation in progranulin. in Archives of neurology 2010 (PubMed)
    Show all 2 references for ABIN1889363

More ELISA Kits for Granulin Interaction Partners

Zebrafish Granulin (GRN) interaction partners

  1. the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes

  2. GrnA positively modulates hepatic MET expression both in vivo and in vitro.

Human Granulin (GRN) interaction partners

  1. progranulin is affected by a decrease in eGFR (show EGFR ELISA Kits), being at a higher concentration in serum and lower in urine of DKD patients with T2DM and eGFR (show EGFR ELISA Kits) <60 mL/min/1.73m2. It is also associated with markers of obesity and inflammation

  2. EphA2 (show EPHA2 ELISA Kits), a member of the large family of Ephrin receptor tyrosine kinases, is a functional signaling receptor for progranulin.

  3. recruitment of granulin-expressing inflammatory monocytes plays a key role in Pancreatic ductal adenocarcinoma metastasis

  4. PGRN expression might help predict treatment outcomes and provide a new target for molecular therapy

  5. Secreted PGRN is incorporated into cells via sortilin (show SORT1 ELISA Kits) or cation-independent mannose 6-phosphate receptor (show IGF2R ELISA Kits), and facilitated the acidification of lysosomes and degradation of CTSDmat. Moreover, the change of PGRN levels led to a cell-type-specific increase of insoluble TDP-43 (show TARDBP ELISA Kits). In the brain tissue of FTLD-TDP patients with PGRN deficiency, CTSD (show CTSD ELISA Kits) and phosphorylated TDP-43 (show TARDBP ELISA Kits) accumulated in neurons

  6. High progranulin expression is associated with Overweight/obese.

  7. human and rodent data suggest that global PGRN reduction induces microglial TYROBP (show TYROBP ELISA Kits) network genes expression

  8. The overexpression of miR588 in lung squamous cell carcinoma cells reduced the mRNA and protein levels of progranulin (GRN), whereas miR588 silencing increased the expression of GRN.

  9. PGRN is upregulated in psoriasis lesions and the overexpression of PGRN inhibits the inflammation in keratinocytes induced by TNF-alpha (show TNF ELISA Kits) by negatively regulating the production of inflammatory factors and positively mediating autophagy through the Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling pathway

  10. PGRN may have great potential as a diagnostic factor for active lupus nephritis and as a predictor for its disease activity.

Mouse (Murine) Granulin (GRN) interaction partners

  1. Knocking down receptor-interacting serine/threonine protein kinase 1 (Ripk1 (show RIPK1 ELISA Kits)) increased both intracellular and extracellular PGRN protein levels by increasing the translation rate of PGRN without affecting mRNA levels.

  2. In progranulin knockout mice, there was no estrogen receptor alpha (show ESR1 ELISA Kits) immunoreactivity in astrocytes in males or females at various ages. These results suggest that PGRN plays a crucial role in the expression of ERalpha (show ESR1 ELISA Kits) in astrocytes regardless of the estrous cycle stage, sex, and maturity.

  3. recruitment of granulin-expressing inflammatory monocytes plays a key role in Pancreatic ductal adenocarcinoma metastasis.

  4. Progranulin causes adipose insulin (show INS ELISA Kits) resistance via increased autophagy resulting from activated oxidative stress and endoplasmic reticulum stress.

  5. Grn+/- mice have biphasic social dominance associated with abnormal neuronal morphology and signaling. Grn-/- mice did not exhibit abnormal social dominance.

  6. human and rodent data suggest that global PGRN reduction induces microglial TYROBP (show TYROBP ELISA Kits) network genes expression

  7. this study shows that PGRN deficiency results in kidney injury, inflammatory cell infiltration, production of pro-inflammatory mediators, while administration of recombinant PGRN ameliorates endotoxin-induced acute kidney injury

  8. Our data demonstrates an unknown association between PGRN and GD and identifies PGRN as an essential factor for GCase's lysosomal localization. These findings not only provide new insight into the pathogenesis of GD, but may also have implications for diagnosis and alternative targeted therapies for GD.

  9. These findings not only demonstrate that PGRN is a co-chaperone of HSP70 (show HSP70 ELISA Kits) and plays an important role in GCase (show GBA ELISA Kits) lysosomal localization, but may also provide new therapeutic interventions for lysosomal storage diseases, in particular GD.

  10. The results suggest that PGRN may affect the differentiation of retinal precursor cells to photoreceptor cells through the HGF receptor signaling pathway.

Guinea Pig Granulin (GRN) interaction partners

  1. ADAM15 (show ADAM15 ELISA Kits) and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.

Granulin (GRN) Antigen Profile

Antigen Summary

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Gene names and symbols associated with Granulin (GRN) ELISA Kits

  • granulin (GRN) antibody
  • granulin a (grna) antibody
  • Granulins (grn) antibody
  • granulin (grn) antibody
  • granulin (granulin) antibody
  • granulin (ORF1 granulin) antibody
  • granulin (Grn) antibody
  • acrogranin antibody
  • CLN11 antibody
  • DKFZp459H066 antibody
  • epithelin antibody
  • GEP antibody
  • GP88 antibody
  • grn antibody
  • MGC53354 antibody
  • PCDGF antibody
  • PEPI antibody
  • PGRN antibody
  • wu:fb11g12 antibody
  • wu:fj18f05 antibody

Protein level used designations for Granulin (GRN) ELISA Kits

granulin , granulin-a , zfPGRN-A , Granulins , PC cell-derived growth factor , acrogranin , granulin-epithelin , granulins , proepithelin , progranulin , PCDGF , PEPI , acrogranulin

GENE ID SPECIES
454728 Pan troglodytes
100051035 Equus caballus
791524 Danio rerio
100195018 Salmo salar
380370 Xenopus laevis
1463344 Adoxophyes orana granulovirus
2776804 Agrotis segetum granulovirus
100173689 Pongo abelii
2896 Homo sapiens
29143 Rattus norvegicus
14824 Mus musculus
480501 Canis lupus familiaris
733645 Sus scrofa
767942 Bos taurus
100135533 Cavia porcellus
100349528 Oryctolagus cuniculus
101115470 Ovis aries
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