Granulin (GRN) ELISA Kits

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Additionally we are shipping Granulin Antibodies (159) and Granulin Proteins (45) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
GRN 2896 P28799
GRN 29143 P23785
GRN 14824  
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Top Granulin ELISA Kits at antibodies-online.com

Showing 9 out of 108 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 50pg/mL 1.56-100 ng/mL Human Progranulin PicoKine ELISA Kit standard curve 96 Tests Log in to see 4 to 6 Days
$369.00
Details
Mouse 10pg/mL 0.78-50 ng/mL Mouse Progranulin PicoKine ELISA Kit standard curve 96 Tests Log in to see 4 to 6 Days
$369.00
Details
Rat 0.065 ng/mL 0.15-10 ng/mL 96 Tests Log in to see 13 to 16 Days
$640.00
Details
Guinea Pig 1.0 pg/mL 50-1000 pg/mL   96 Tests Log in to see 15 to 18 Days
$707.14
Details
Rabbit 1.0 pg/mL 50-1000 pg/mL   96 Tests Log in to see 15 to 18 Days
$707.14
Details
Chicken 1.875 ng/mL 3.125-200 ng/mL   96 Tests Log in to see 12 to 14 Days
$715.00
Details
Pig 0.938 ng/mL 1.563-100 ng/mL   96 Tests Log in to see 12 to 14 Days
$715.00
Details
Monkey 1.0 pg/mL 250-5000 pg/mL   96 Tests Log in to see 15 to 18 Days
$707.14
Details
Dog 1.0 pg/mL 50-1000 pg/mL   96 Tests Log in to see 15 to 18 Days
$707.14
Details

Top referenced Granulin ELISA Kits

  1. Human Granulin ELISA Kit for Sandwich ELISA - ABIN1672874 : Ahmed, Sheng, Xu, Lin, Innes, Gass, Yu, Wuertzer, Hou, Chiba, Yamanouchi, Leissring, Petrucelli, Nishihara, Hutton, McGowan, Dickson, Lewis: Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging. in The American journal of pathology 2010 (PubMed)
    Show all 2 references for 1672874

  2. Mouse (Murine) Granulin ELISA Kit for Sandwich ELISA - ABIN1889363 : Kelley, Haidar, Boeve, Baker, Shiung, Knopman, Rademakers, Hutton, Adamson, Kuntz, Dickson, Parisi, Smith, Petersen: Alzheimer disease-like phenotype associated with the c.154delA mutation in progranulin. in Archives of neurology 2010 (PubMed)
    Show all 2 references for 1889363

More ELISA Kits for Granulin Interaction Partners

Zebrafish Granulin (GRN) interaction partners

  1. Findings show that miR (show MYLIP ELISA Kits)-145 and GrnA expression patterns are inversely correlated during liver development and provide evidence that GrnA-dependent hepatic outgrowth is regulated by miR (show MYLIP ELISA Kits)-145 in zebrafish embryonic development.

  2. the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes

  3. GrnA positively modulates hepatic MET expression both in vivo and in vitro.

Human Granulin (GRN) interaction partners

  1. the influence of the p.A152T MAPT (show MAPT ELISA Kits) variant on the clinical and neuropathological features of these Basque GRN families, is reported.

  2. Results indicate that central nervous progranulin reduction is not restricted to the relatively rare cases of frontotemporal dementia caused by progranulin gene (GRN) loss of function mutations, but also contributes to the more common GRN-negative forms of frontotemporal dementia.

  3. a complete screening for mutations in MAPT, GRN and C9ORF72 genes revealed a frequency of 5.4% of pathogenic mutations in a random cohort of 93 Turkish index patients with dementia

  4. This Progress article reviews recent advances in progranulin biology emphasizing its roles in lysosomal function and brain innate immunity, and outlines future avenues of investigation that may lead to new therapeutic approaches for neurodegeneration--{REVIEW}

  5. serum progranulin levels had a positive correlation with pulmonary function in patients with asthma and a negative correlation with blood neutrophil counts.

  6. Progranulin (PGRN), a 593-amino-acid autocrine growth factor has multiple functions involved in cell proliferation, wound healing, neurodegeneration, insulin (show INS ELISA Kits) resistance, and tumorigenesis.

  7. progranulin is affected by a decrease in eGFR (show EGFR ELISA Kits), being at a higher concentration in serum and lower in urine of DKD patients with T2DM and eGFR (show EGFR ELISA Kits) <60 mL/min/1.73m2. It is also associated with markers of obesity and inflammation

  8. EphA2 (show EPHA2 ELISA Kits), a member of the large family of Ephrin receptor tyrosine kinases, is a functional signaling receptor for progranulin.

  9. recruitment of granulin-expressing inflammatory monocytes plays a key role in Pancreatic ductal adenocarcinoma metastasis

  10. PGRN expression might help predict treatment outcomes and provide a new target for molecular therapy

Mouse (Murine) Granulin (GRN) interaction partners

  1. Grn and Tmem106b genes have opposite effects on lysosomal enzyme levels, and their interaction determines the extent of neurodegeneration

  2. PGRN induction of IL-10 (show IL10 ELISA Kits) in Treg cells depends on FOXO4 (show FOXO4 ELISA Kits) and Stat3 (show STAT3 ELISA Kits).

  3. ECM1 (show ECM1 ELISA Kits) seems to be critical for PTHrP (show PTHLH ELISA Kits) action in chondrogenesis, as blockage of ECM1 (show ECM1 ELISA Kits) nearly abolishes PTHrP (show PTHLH ELISA Kits) regulation of chondrocyte hypertrophy, and overexpression of ECM1 (show ECM1 ELISA Kits) rescues disorganized growth plates of PTHrP (show PTHLH ELISA Kits)-null mice; ECM1 (show ECM1 ELISA Kits) and progranulin chondrogenic growth factor constitute an interaction network.

  4. Knocking down receptor-interacting serine/threonine protein kinase 1 (Ripk1 (show RIPK1 ELISA Kits)) increased both intracellular and extracellular PGRN protein levels by increasing the translation rate of PGRN without affecting mRNA levels.

  5. In progranulin knockout mice, there was no estrogen receptor alpha (show ESR1 ELISA Kits) immunoreactivity in astrocytes in males or females at various ages. These results suggest that PGRN plays a crucial role in the expression of ERalpha (show ESR1 ELISA Kits) in astrocytes regardless of the estrous cycle stage, sex, and maturity.

  6. recruitment of granulin-expressing inflammatory monocytes plays a key role in Pancreatic ductal adenocarcinoma metastasis.

  7. Progranulin causes adipose insulin (show INS ELISA Kits) resistance via increased autophagy resulting from activated oxidative stress and endoplasmic reticulum stress.

  8. Grn+/- mice have biphasic social dominance associated with abnormal neuronal morphology and signaling. Grn-/- mice did not exhibit abnormal social dominance.

  9. human and rodent data suggest that global PGRN reduction induces microglial TYROBP (show TYROBP ELISA Kits) network genes expression

  10. this study shows that PGRN deficiency results in kidney injury, inflammatory cell infiltration, production of pro-inflammatory mediators, while administration of recombinant PGRN ameliorates endotoxin-induced acute kidney injury

Guinea Pig Granulin (GRN) interaction partners

  1. ADAM15 (show ADAM15 ELISA Kits) and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.

Granulin (GRN) Antigen Profile

Antigen Summary

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Gene names and symbols associated with Granulin (GRN) ELISA Kits

  • granulin (GRN) antibody
  • granulin a (grna) antibody
  • Granulins (grn) antibody
  • granulin (grn) antibody
  • granulin (granulin) antibody
  • granulin (ORF1 granulin) antibody
  • granulin (Grn) antibody
  • acrogranin antibody
  • CLN11 antibody
  • DKFZp459H066 antibody
  • epithelin antibody
  • GEP antibody
  • GP88 antibody
  • grn antibody
  • MGC53354 antibody
  • PCDGF antibody
  • PEPI antibody
  • PGRN antibody
  • wu:fb11g12 antibody
  • wu:fj18f05 antibody

Protein level used designations for Granulin (GRN) ELISA Kits

granulin , granulin-a , zfPGRN-A , Granulins , PC cell-derived growth factor , acrogranin , granulin-epithelin , granulins , proepithelin , progranulin , PCDGF , PEPI , acrogranulin

GENE ID SPECIES
454728 Pan troglodytes
100051035 Equus caballus
791524 Danio rerio
100195018 Salmo salar
380370 Xenopus laevis
1463344 Adoxophyes orana granulovirus
2776804 Agrotis segetum granulovirus
100173689 Pongo abelii
2896 Homo sapiens
29143 Rattus norvegicus
14824 Mus musculus
480501 Canis lupus familiaris
733645 Sus scrofa
767942 Bos taurus
100135533 Cavia porcellus
100349528 Oryctolagus cuniculus
101115470 Ovis aries
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