Granulin (GRN) ELISA Kits

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Additionally we are shipping Granulin Antibodies (162) and Granulin Proteins (43) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
GRN 2896 P28799
GRN 29143 P23785
GRN 14824  
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Top Granulin ELISA Kits at antibodies-online.com

Showing 10 out of 116 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.63 ng/mL 1.56 ng/mL - 100 ng/mL 96 Tests Log in to see 13 to 16 Days
$589.47
Details
Mouse 13.6 pg/mL 31.2 pg/mL - 2000 pg/mL 96 Tests Log in to see 13 to 16 Days
$606.32
Details
Rat 0.065 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Log in to see 13 to 16 Days
$640.00
Details
Rabbit 0.1 ng/mL 0.5-10 ng/mL   96 Tests Log in to see 15 to 18 Days
$707.14
Details
Guinea Pig 0.1 ng/mL 0.5-10 ng/mL   96 Tests Log in to see 15 to 18 Days
$707.14
Details
Dog 0.1 ng/mL 0.5-10 ng/mL   96 Tests Log in to see 15 to 18 Days
$707.14
Details
Pig
  96 Tests Log in to see 15 to 18 Days
$707.14
Details
Human 0.64 ng/mL 1.56 ng/mL - 100 ng/mL   96 Tests Log in to see 8 to 12 Days
$766.25
Details
Chicken 1.875 ng/mL 3.125-200 ng/mL   96 Tests Log in to see 12 to 14 Days
$715.00
Details
Sheep
  96 Tests Log in to see 15 to 18 Days
$707.14
Details

Top referenced Granulin ELISA Kits

  1. Human Granulin ELISA Kit for Sandwich ELISA - ABIN578626 : Qu, Deng, Hu: Plasma progranulin concentrations are increased in patients with type 2 diabetes and obesity and correlated with insulin resistance. in Mediators of inflammation 2013 (PubMed)
    Show all 2 Pubmed References

  2. Rat (Rattus) Granulin ELISA Kit for Sandwich ELISA - ABIN4881274 : Zhou, Xie, Wang, Zhang, Chen, Zhang, Wu, Wei, Ding, Hang, Zhou, Shi: Decreased progranulin levels in patients and rats with subarachnoid hemorrhage: a potential role in inhibiting inflammation by suppressing neutrophil recruitment. in Journal of neuroinflammation 2015 (PubMed)

More ELISA Kits for Granulin Interaction Partners

Zebrafish Granulin (GRN) interaction partners

  1. Findings show that miR (show MYLIP ELISA Kits)-145 and GrnA expression patterns are inversely correlated during liver development and provide evidence that GrnA-dependent hepatic outgrowth is regulated by miR (show MYLIP ELISA Kits)-145 in zebrafish embryonic development.

  2. the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes

  3. GrnA positively modulates hepatic MET expression both in vivo and in vitro.

Human Granulin (GRN) interaction partners

  1. progranulin expression is critical for tumor growth in vivo, in both xenograft and orthotopic tumor models

  2. results revealed an important role of NF-kappaB (show NFKB1 ELISA Kits) signalling in PGRN-associated frontotemporal lobar degeneration-DNA-binding protein (show UBE2V1 ELISA Kits) 43 and confirm that PGRN can bind to TNF-alpha (show TNF ELISA Kits) receptors regulating the expression of WNT5A (show WNT5A ELISA Kits), suggesting novel targets for treatment of frontotemporal lobar degeneration-DNA-binding protein (show UBE2V1 ELISA Kits) linked to GRN mutations.

  3. These results suggest an important role of Wnt (show WNT2 ELISA Kits) activation inducing cell cycle disturbance-mediated neuronal loss in the pathogenesis of PGRN deficiency-linked frontotemporal lobar degeneration with TDP-43 (show TARDBP ELISA Kits) protein inclusions.

  4. Study demonstrate that PGRN interacts with the lysosomal protease CTSD (show CTSD ELISA Kits) and maintains its proper activity in vivo. Therefore, by regulating CTSD (show CTSD ELISA Kits) activity, PGRN may modulate protein homeostasis. This could potentially explain the TDP-43 (show TARDBP ELISA Kits) aggregation observed in frontotemporal lobar degeneration with GRN mutations.

  5. Data indicate significant correlation of granulin-epithelin precursor (GEP (show GNA12 ELISA Kits)) with beta-catenin (show CTNNB1 ELISA Kits) in hepatocellular carcinoma (HCC (show FAM126A ELISA Kits)) cohort.

  6. We identified 3 novel GRN mutations (p.Q130X, p.317Afs*12, and p.K259Afs*23) in patients diagnosed with nonfluent-variant PPA (show PPA1 ELISA Kits) or behavioral-variant FTD (show FTL ELISA Kits). The frequency of GRN mutations was 9.6% and that of MAPT (show MAPT ELISA Kits) mutations was 7.1%. Among familial cases of FTD (show FTL ELISA Kits), the frequency of GRN mutations was 31.5% and that of MAPT (show MAPT ELISA Kits) mutations was 10.5% in Brazil.

  7. Missense mutation in GRN gene affecting RNA splicing and plasma progranulin level in a family affected by frontotemporal lobar degeneration.

  8. GRN gene deletion is genetic etiology of familial frontotemporal dementia.

  9. Thisstudy has demonstrated the effect of inflammatory cytokine on cartilage graft as well as the protective role of PGRN on this graft. Without the anti-inflammatory effect from PGRN, hyaline cartilaginous extracellular matrices in living hyaline cartilage graft constructs could be easily remodeled into fibrotic or mineralized tissue and would no longer be able to fulfil the role of a cartilage graft.

  10. This study demonstrated that the GRN mutation carriers showed significant frontoparietal hypoperfusion compared with controls at follow-up.

Mouse (Murine) Granulin (GRN) interaction partners

  1. The results of this study show that endogenous and recombinant PGRN limit axonal injury and astrogliosis and suggest therapeutic potential of PGRN in traumatic brain injury.

  2. progranulin expression is critical for tumor growth in vivo, in both xenograft and orthotopic tumor models

  3. Study demonstrate that PGRN interacts with the lysosomal protease CTSD (show CTSD ELISA Kits) and maintains its proper activity in vivo. Therefore, by regulating CTSD (show CTSD ELISA Kits) activity, PGRN may modulate protein homeostasis. This could potentially explain the TDP-43 (show TARDBP ELISA Kits) aggregation observed in frontotemporal lobar degeneration with GRN mutations.

  4. Findings suggest that elevated PGRN is linked to cognitive deficits of fragile X (show FMR1 ELISA Kits) syndrome.

  5. highlight an important role for neuron-derived progranulin in maintaining normal social function.

  6. overexpression of PGRN was also found to increase activity of neprilysin (show MME ELISA Kits), a key amyloid beta degrading enzyme. PGRN regulation of neprilysin (show MME ELISA Kits) activity could play a major role in the observed alterations in plaque burden

  7. PGRN decrease, resulting from pathogenic mutations, might compromise the trophism of cortical neurons by affecting GluN2B (show GRIN2B ELISA Kits)-contaning NMDA receptors

  8. The PGRN is a nonredundant regulator of systemic inflammation via modulating the levels and activity of C/EBPalpha, IL-10, and the ubiquitin-proteasome proteolysis pathway.

  9. Grn and Tmem106b genes have opposite effects on lysosomal enzyme levels, and their interaction determines the extent of neurodegeneration

  10. PGRN induction of IL-10 (show IL10 ELISA Kits) in Treg cells depends on FOXO4 (show FOXO4 ELISA Kits) and Stat3 (show STAT3 ELISA Kits).

Guinea Pig Granulin (GRN) interaction partners

  1. ADAM15 (show ADAM15 ELISA Kits) and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.

Granulin (GRN) Antigen Profile

Antigen Summary

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Gene names and symbols associated with Granulin (GRN) ELISA Kits

  • granulin precursor (GRN) antibody
  • granulin a (grna) antibody
  • Granulins (grn) antibody
  • granulin L homeolog (grn.L) antibody
  • granulin (granulin) antibody
  • granulin (ORF1 granulin) antibody
  • granulin precursor (Grn) antibody
  • granulin (Grn) antibody
  • acrogranin antibody
  • CLN11 antibody
  • DKFZp459H066 antibody
  • epithelin antibody
  • GEP antibody
  • GP88 antibody
  • grn antibody
  • MGC53354 antibody
  • PCDGF antibody
  • PEPI antibody
  • PGRN antibody
  • wu:fb11g12 antibody
  • wu:fj18f05 antibody

Protein level used designations for Granulin (GRN) ELISA Kits

granulin , granulin-a , zfPGRN-A , Granulins , PC cell-derived growth factor , acrogranin , granulin-epithelin , granulins , proepithelin , progranulin , PCDGF , PEPI , acrogranulin

GENE ID SPECIES
454728 Pan troglodytes
100051035 Equus caballus
791524 Danio rerio
100195018 Salmo salar
380370 Xenopus laevis
1463344 Adoxophyes orana granulovirus
2776804 Agrotis segetum granulovirus
100173689 Pongo abelii
2896 Homo sapiens
29143 Rattus norvegicus
14824 Mus musculus
480501 Canis lupus familiaris
733645 Sus scrofa
767942 Bos taurus
100135533 Cavia porcellus
100349528 Oryctolagus cuniculus
101115470 Ovis aries
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