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Granulin Proteins

(Granulin (GRN))

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008].

recommended

Granulin Protein (GRN) (AA 494-593) (GST tag) (ABIN1355792)

GRN Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP

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recommended

Granulin Protein (GRN) (AA 364-430) (His tag) (ABIN7123193)

GRN Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA

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recommended

Granulin Protein (GRN) (AA 289-426) (His-IF2DI Tag) (ABIN7123192)

GRN Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA

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Granulin Proteins by Grade

Find Granulin Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

Granulin Proteins by Origin

Find Granulin Proteins for a variety of species such as anti-Human Granulin, anti-Mouse Granulin, anti-Rat Granulin. The species listed below are among those available. Click on a link to go to the corresponding products.

Granulin Proteins by Source

Here you will find Granulin Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

Granulin Proteins by Protein Type

Here you can find Granulin Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

Granulin Proteins by Application

Find Granulin Proteins validated for a specific application such as ELISA, SDS, WB, Imm. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Granulin Proteins by Biological Activity

Find Granulin Proteins with a specific Biological Activity. The Biological Activity listed below are among those available. Click on a link to go to the corresponding products.

Popular Granulin Proteins

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

Granulin Protein (GRN) (AA 494-593) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1355792

Quantity 10 μg

Datasheet Datasheet

Granulin Protein (GRN) (AA 364-430) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7123193

Quantity 50 μg

Datasheet Datasheet

Granulin Protein (GRN) (AA 289-426) (His-IF2DI Tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7123192

Quantity 50 μg

Datasheet Datasheet

Granulin Protein (GRN) (AA 1-593) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1355791

Quantity 25 μg

Datasheet Datasheet

Granulin Protein (GRN) (His tag)

Reactivity Mouse

Source HEK-293 Cells

Validations

Cat. No. ABIN7320292

Quantity 100 μg

Datasheet Datasheet

Granulin Protein (GRN) (AA 18-593) (His tag)

Reactivity Human

Source Insect Cells

Validations

Cat. No. ABIN3080977

Quantity 1 mg

Datasheet Datasheet

Granulin Protein (GRN) (AA 18-589) (His tag)

Reactivity Mouse

Source Insect Cells

Validations

Cat. No. ABIN3133601

Quantity 1 mg

Datasheet Datasheet

Granulin Protein (GRN) (AA 1-593) (DYKDDDDK Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN5564454

Quantity 10 μg

Datasheet Datasheet

Granulin Protein (GRN) (AA 1-602) (DYKDDDDK Tag)

Reactivity Rat

Source HEK-293 Cells

Validations

Cat. No. ABIN1344102

Quantity 10 μg

Datasheet Datasheet

Granulin Protein (GRN) (AA 1-589)

Reactivity Mouse

Source HEK-293 Cells

Validations

Cat. No. ABIN5564458

Quantity 10 μg

Datasheet Datasheet

Granulin Protein (GRN) (AA 1-602)

Reactivity Rat

Source HEK-293 Cells

Validations

Cat. No. ABIN5564460

Quantity 10 μg

Datasheet Datasheet

Granulin Protein (GRN) (AA 1-593)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN5564456

Quantity 10 μg

Datasheet Datasheet

Granulin Protein (GRN) (AA 234-419) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7401248

Quantity 100 μg

Datasheet Datasheet

Granulin Protein (GRN) (AA 1-593) (His tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN7505668

Quantity 100 μg

Datasheet Datasheet

Granulin Protein (GRN) (His tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN7520050

Quantity 50 μg

Datasheet Datasheet

Latest Publications for our Granulin Proteins

Wang, Yang, Tian, Gao, Shen, Ren, Li, Jiang, Dong: "Tumor necrosis factor receptor 2/AKT and ERK signaling pathways contribute to the switch from fibroblasts to CAFs by progranulin in microenvironment of colorectal cancer." in: Oncotarget, Vol. 8, Issue 16, pp. 26323-26333, (2018) (PubMed).

Suárez-Calvet, Capell, Araque Caballero, Morenas-Rodríguez, Fellerer, Franzmeier, Kleinberger, Eren, Deming, Piccio, Karch, Cruchaga, Paumier, Bateman, Fagan, Morris, Levin, Danek, Jucker, Masters et al.: "CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline. ..." in: EMBO molecular medicine, Vol. 10, Issue 12, (2018) (PubMed).

Chen, Chang, Deng, Xu, Nguyen, Martens, Cenik, Taylor, Hudson, Chung, Yu, Yu, Herz, Farese, Kukar, Tansey: "Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 21, pp. 9202-13, (2013) (PubMed).

De Muynck, Herdewyn, Beel, Scheveneels, Van Den Bosch, Robberecht, Van Damme: "The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding." in: Neurobiology of aging, Vol. 34, Issue 11, pp. 2541-7, (2013) (PubMed).

Kim, Shin, Youn, Namkoong, Gil, Kang, Yu, Kim: "Involvement of progranulin in hypothalamic glucose sensing and feeding regulation." in: Endocrinology, Vol. 152, Issue 12, pp. 4672-82, (2011) (PubMed).

Van Damme, Van Hoecke, Lambrechts, Vanacker, Bogaert, van Swieten, Carmeliet, Van Den Bosch, Robberecht: "Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival." in: The Journal of cell biology, Vol. 181, Issue 1, pp. 37-41, (2008) (PubMed).

Aliases for Granulin Proteins

granulin precursor (GRN) Proteins
granulin a (grna) Proteins
Granulins (grn) Proteins
granulin L homeolog (grn.L) Proteins
granulin (granulin) Proteins
granulin (ORF1 granulin) Proteins
granulin precursor (Grn) Proteins
granulin (Grn) Proteins
acrogranin Proteins
CLN11 Proteins
DKFZp459H066 Proteins
epithelin Proteins
GEP Proteins
GP88 Proteins
GRN Proteins
grn Proteins
MGC53354 Proteins
PCDGF Proteins
PEPI Proteins
PGRN Proteins
wu:fb11g12 Proteins
wu:fj18f05 Proteins

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Granulin Proteins by Grade

Granulin Proteins by Origin

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Granulin Proteins by Biological Activity

Popular Granulin Proteins

Latest Publications for our Granulin Proteins

Aliases for Granulin Proteins

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