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Granulin Proteins (GRN)

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Additionally we are shipping Granulin Antibodies (155) and Granulin Kits (103) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GRN 2896 P28799
GRN 29143 P23785
GRN 14824  
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Top Granulin Proteins at antibodies-online.com

Showing 10 out of 37 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
$7,759.50
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
$7,759.50
Details
HOST_HEK-293 Cells Rat Un-conjugated 50 μg Log in to see 2 to 3 Days
$829.50
Details
HOST_HEK-293 Cells Mouse Un-conjugated 50 μg Log in to see 2 to 3 Days
$829.50
Details
HOST_HEK-293 Cells Rat Un-conjugated 50 μg Log in to see 2 to 3 Days
$876.75
Details
HOST_HEK-293 Cells Mouse Un-conjugated 50 μg Log in to see 2 to 3 Days
$876.75
Details
HOST_HEK-293 Cells Human Un-conjugated 50 μg Log in to see 2 to 3 Days
$876.75
Details
HOST_Human Cells Human His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details

GRN Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , ,
, , ,
Rat (Rattus) , ,
,
Mouse (Murine) , , ,
,

Top referenced Granulin Proteins

  1. Human Granulin Protein expressed in Wheat germ - ABIN1355792 : Chen, Chang, Deng, Xu, Nguyen, Martens, Cenik, Taylor, Hudson, Chung, Yu, Yu, Herz, Farese, Kukar, Tansey: Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 (PubMed)
    Show all 3 references for ABIN1355792

More Proteins for Granulin (GRN) Interaction Partners

Zebrafish Granulin (GRN) interaction partners

  1. the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes

  2. GrnA positively modulates hepatic MET expression both in vivo and in vitro.

Human Granulin (GRN) interaction partners

  1. High progranulin expression is associated with Overweight/obese.

  2. human and rodent data suggest that global PGRN reduction induces microglial TYROBP (show TYROBP Proteins) network genes expression

  3. The overexpression of miR588 in lung squamous cell carcinoma cells reduced the mRNA and protein levels of progranulin (GRN), whereas miR588 silencing increased the expression of GRN.

  4. PGRN is upregulated in psoriasis lesions and the overexpression of PGRN inhibits the inflammation in keratinocytes induced by TNF-alpha (show TNF Proteins) by negatively regulating the production of inflammatory factors and positively mediating autophagy through the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway

  5. PGRN may have great potential as a diagnostic factor for active lupus nephritis and as a predictor for its disease activity.

  6. GRN rs5458 may decrease the risk of PD in Chinese individuals.

  7. Our report extends the evidence for genetic and phenotypic variability in frontotemporal lobar degeneration (FTLD) disorders, and detects a novel pathogenic GRN mutation, carriers of which could eventually help to evaluate the efficacy of different treatments at early stages of dementia

  8. Results support further examination of PGRN as a potential marker in neurodegenerative diseases, since PGRN is stable in serum and CSF (show CSF2 Proteins) and can be measured using ELISA kits from several providers

  9. Our data demonstrates an unknown association between PGRN and GD and identifies PGRN as an essential factor for GCase's lysosomal localization. These findings not only provide new insight into the pathogenesis of GD, but may also have implications for diagnosis and alternative targeted therapies for GD.

  10. Studied levels of salivary visfatin (show NAMPT Proteins), chemerin (show RARRES2 Proteins), and progranulin and in gingivitis, periodontitis, as well as healthy patients. Salivary progranulin levels were similar in all groups; chemerin (show RARRES2 Proteins) was detected at higher levels in the periodontitis group compared to the gingivitis and the healthy groups; visfatin (show NAMPT Proteins) levels were higher in patients with gingivitis and periodontitis compared to those of healthy subjects.

Mouse (Murine) Granulin (GRN) interaction partners

  1. human and rodent data suggest that global PGRN reduction induces microglial TYROBP (show TYROBP Proteins) network genes expression

  2. this study shows that PGRN deficiency results in kidney injury, inflammatory cell infiltration, production of pro-inflammatory mediators, while administration of recombinant PGRN ameliorates endotoxin-induced acute kidney injury

  3. Our data demonstrates an unknown association between PGRN and GD and identifies PGRN as an essential factor for GCase's lysosomal localization. These findings not only provide new insight into the pathogenesis of GD, but may also have implications for diagnosis and alternative targeted therapies for GD.

  4. These findings not only demonstrate that PGRN is a co-chaperone of HSP70 (show HSP70 Proteins) and plays an important role in GCase (show GBA Proteins) lysosomal localization, but may also provide new therapeutic interventions for lysosomal storage diseases, in particular GD.

  5. The results suggest that PGRN may affect the differentiation of retinal precursor cells to photoreceptor cells through the HGF receptor signaling pathway.

  6. PGRN is overexpressed in the early stage of endotoxic shock in mice.

  7. Deleting C1qa (show C1QA Proteins) gene significantly reduces synaptic pruning by Grn(-/-) microglia and mitigates neurodegeneration, behavioral phenotypes, and premature mortality in Grn(-/-) mice; results uncover a previously unrecognized role of progranulin in suppressing aberrant microglia activation during aging.

  8. CXCL9 (show CXCL9 Proteins) expression is strongly upregulated in PGRN KO mice and its level is correlated with severity of inflammation in a dermatitis model.

  9. Progranulin suppresses titanium particle induced inflammatory osteolysis by targeting TNFalpha (show TNF Proteins) signaling.

  10. Data show that progranulin is upregulated in neuroendocrine tumors (NETs) and islets of the multiple endocrine neoplasia 1 (show MEN1 Proteins) protein (MEN1 (show MEN1 Proteins)) mouse as well as in the serum of patients with pancreatic NETs associated with glucagonoma syndrome.

Guinea Pig Granulin (GRN) interaction partners

  1. ADAM15 (show ADAM15 Proteins) and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.

Granulin (GRN) Protein Profile

Protein Summary

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Gene names and symbols associated with Granulin Proteins (GRN)

  • granulin (GRN)
  • granulin a (grna)
  • Granulins (grn)
  • granulin (grn)
  • granulin (granulin)
  • granulin (ORF1 granulin)
  • granulin (Grn)
  • acrogranin protein
  • CLN11 protein
  • DKFZp459H066 protein
  • epithelin protein
  • GEP protein
  • GP88 protein
  • grn protein
  • MGC53354 protein
  • PCDGF protein
  • PEPI protein
  • PGRN protein
  • wu:fb11g12 protein
  • wu:fj18f05 protein

Protein level used designations for Granulin Proteins (GRN)

granulin , granulin-a , zfPGRN-A , Granulins , PC cell-derived growth factor , acrogranin , granulin-epithelin , granulins , proepithelin , progranulin , PCDGF , PEPI , acrogranulin

GENE ID SPECIES
454728 Pan troglodytes
100051035 Equus caballus
791524 Danio rerio
100195018 Salmo salar
380370 Xenopus laevis
1463344 Adoxophyes orana granulovirus
2776804 Agrotis segetum granulovirus
100173689 Pongo abelii
2896 Homo sapiens
29143 Rattus norvegicus
14824 Mus musculus
480501 Canis lupus familiaris
733645 Sus scrofa
767942 Bos taurus
100135533 Cavia porcellus
100349528 Oryctolagus cuniculus
101115470 Ovis aries
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