Granulin Proteins (GRN)

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Additionally we are shipping Granulin Antibodies (159) and Granulin Kits (108) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GRN 2896 P28799
GRN 29143 P23785
GRN 14824  
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Top Granulin Proteins at antibodies-online.com

Showing 10 out of 45 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Rat DYKDDDDK Tag 50 μg Log in to see 2 to 3 Days
$765.00
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
HOST_HEK-293 Cells Rat Un-conjugated 50 μg Log in to see 2 to 3 Days
$810.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_HEK-293 Cells Mouse DYKDDDDK Tag 50 μg Log in to see 2 to 3 Days
$765.00
Details
Yeast REACT_Agrotis segetum granulosis virus His tag   1 mg Log in to see 60 to 71 Days
$2,632.67
Details
Yeast REACT_Xestia c-nigrum granulosis virus His tag   1 mg Log in to see 60 to 71 Days
$2,634.50
Details
Yeast REACT_Cydia pomonella granulosis virus His tag   1 mg Log in to see 60 to 71 Days
$2,634.50
Details
HOST_HEK-293 Cells Human Un-conjugated 50 μg Log in to see 2 to 3 Days
$810.00
Details

GRN Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , , ,
Rat (Rattus) ,
,
Mouse (Murine) , , ,
, ,

Top referenced Granulin Proteins

  1. Human Granulin Protein expressed in Wheat germ - ABIN1355792 : Chen, Chang, Deng, Xu, Nguyen, Martens, Cenik, Taylor, Hudson, Chung, Yu, Yu, Herz, Farese, Kukar, Tansey: Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 (PubMed)
    Show all 3 Pubmed References

More Proteins for Granulin (GRN) Interaction Partners

Zebrafish Granulin (GRN) interaction partners

  1. Findings show that miR (show MYLIP Proteins)-145 and GrnA expression patterns are inversely correlated during liver development and provide evidence that GrnA-dependent hepatic outgrowth is regulated by miR (show MYLIP Proteins)-145 in zebrafish embryonic development.

  2. the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes

  3. GrnA positively modulates hepatic MET expression both in vivo and in vitro.

Human Granulin (GRN) interaction partners

  1. Thisstudy has demonstrated the effect of inflammatory cytokine on cartilage graft as well as the protective role of PGRN on this graft. Without the anti-inflammatory effect from PGRN, hyaline cartilaginous extracellular matrices in living hyaline cartilage graft constructs could be easily remodeled into fibrotic or mineralized tissue and would no longer be able to fulfil the role of a cartilage graft.

  2. This study demonstrated that the GRN mutation carriers showed significant frontoparietal hypoperfusion compared with controls at follow-up.

  3. The GRN risk SNP (rs5848) was associated with variation in detected levels of CSF (show CSF2 Proteins) proteins previously implicated in CNS inflammation. The same GRN risk allele was also associated with increased CSF (show CSF2 Proteins) tau which may indicate directly related neurodegenerative changes.

  4. Granulin is deposited in specific brain regions that differ between Alzheimer's disease patients and Frontotemporal lobar degeneration patients.

  5. Mutation of GRN is a common cause of FTD (show FTL Proteins) in mainland China.

  6. the influence of the p.A152T MAPT (show MAPT Proteins) variant on the clinical and neuropathological features of these Basque GRN families, is reported.

  7. Results indicate that central nervous progranulin reduction is not restricted to the relatively rare cases of frontotemporal dementia caused by progranulin gene (GRN) loss of function mutations, but also contributes to the more common GRN-negative forms of frontotemporal dementia.

  8. a complete screening for mutations in MAPT (show MAPT Proteins), GRN and C9ORF72 (show C9ORF72 Proteins) genes revealed a frequency of 5.4% of pathogenic mutations in a random cohort of 93 Turkish index patients with dementia

  9. This Progress article reviews recent advances in progranulin biology emphasizing its roles in lysosomal function and brain innate immunity, and outlines future avenues of investigation that may lead to new therapeutic approaches for neurodegeneration--{REVIEW}

  10. serum progranulin levels had a positive correlation with pulmonary function in patients with asthma and a negative correlation with blood neutrophil counts.

Mouse (Murine) Granulin (GRN) interaction partners

  1. highlight an important role for neuron-derived progranulin in maintaining normal social function.

  2. overexpression of PGRN was also found to increase activity of neprilysin (show MME Proteins), a key amyloid beta degrading enzyme. PGRN regulation of neprilysin (show MME Proteins) activity could play a major role in the observed alterations in plaque burden

  3. PGRN decrease, resulting from pathogenic mutations, might compromise the trophism of cortical neurons by affecting GluN2B (show GRIN2B Proteins)-contaning NMDA receptors

  4. The PGRN is a nonredundant regulator of systemic inflammation via modulating the levels and activity of C/EBPalpha, IL-10, and the ubiquitin-proteasome proteolysis pathway.

  5. Grn and Tmem106b genes have opposite effects on lysosomal enzyme levels, and their interaction determines the extent of neurodegeneration

  6. PGRN induction of IL-10 (show IL10 Proteins) in Treg cells depends on FOXO4 (show FOXO4 Proteins) and Stat3 (show STAT3 Proteins).

  7. ECM1 (show ECM1 Proteins) seems to be critical for PTHrP action in chondrogenesis, as blockage of ECM1 (show ECM1 Proteins) nearly abolishes PTHrP regulation of chondrocyte hypertrophy, and overexpression of ECM1 (show ECM1 Proteins) rescues disorganized growth plates of PTHrP-null mice; ECM1 (show ECM1 Proteins) and progranulin chondrogenic growth factor constitute an interaction network.

  8. Knocking down receptor-interacting serine/threonine protein kinase 1 (Ripk1 (show RIPK1 Proteins)) increased both intracellular and extracellular PGRN protein levels by increasing the translation rate of PGRN without affecting mRNA levels.

  9. In progranulin knockout mice, there was no estrogen receptor alpha (show ESR1 Proteins) immunoreactivity in astrocytes in males or females at various ages. These results suggest that PGRN plays a crucial role in the expression of ERalpha (show ESR1 Proteins) in astrocytes regardless of the estrous cycle stage, sex, and maturity.

  10. recruitment of granulin-expressing inflammatory monocytes plays a key role in Pancreatic ductal adenocarcinoma metastasis.

Guinea Pig Granulin (GRN) interaction partners

  1. ADAM15 (show ADAM15 Proteins) and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.

Granulin (GRN) Protein Profile

Protein Summary

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Gene names and symbols associated with Granulin Proteins (GRN)

  • granulin (GRN)
  • granulin a (grna)
  • Granulins (grn)
  • granulin (grn)
  • granulin (granulin)
  • granulin (ORF1 granulin)
  • granulin (Grn)
  • acrogranin protein
  • CLN11 protein
  • DKFZp459H066 protein
  • epithelin protein
  • GEP protein
  • GP88 protein
  • grn protein
  • MGC53354 protein
  • PCDGF protein
  • PEPI protein
  • PGRN protein
  • wu:fb11g12 protein
  • wu:fj18f05 protein

Protein level used designations for Granulin Proteins (GRN)

granulin , granulin-a , zfPGRN-A , Granulins , PC cell-derived growth factor , acrogranin , granulin-epithelin , granulins , proepithelin , progranulin , PCDGF , PEPI , acrogranulin

GENE ID SPECIES
454728 Pan troglodytes
100051035 Equus caballus
791524 Danio rerio
100195018 Salmo salar
380370 Xenopus laevis
1463344 Adoxophyes orana granulovirus
2776804 Agrotis segetum granulovirus
100173689 Pongo abelii
2896 Homo sapiens
29143 Rattus norvegicus
14824 Mus musculus
480501 Canis lupus familiaris
733645 Sus scrofa
767942 Bos taurus
100135533 Cavia porcellus
100349528 Oryctolagus cuniculus
101115470 Ovis aries
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