Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) Proteins (GZMH)

The protein encoded by GZMH is a member of the granzyme family. Additionally we are shipping Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) Antibodies (31) and Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GZMH 2999 P20718
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Top Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) Proteins at

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 10 μg Log in to see 20 to 21 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HOST_Escherichia coli (E. coli) Human T7 tag,His tag   100 μg Log in to see 15 to 18 Days

GZMH Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,

Top referenced Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) Proteins

  1. Human GZMH Protein expressed in Human Cells - ABIN2002643 : MacIvor, Pham, Ley: The 5' flanking region of the human granzyme H gene directs expression to T/natural killer cell progenitors and lymphokine-activated killer cells in transgenic mice. in Blood 1999 (PubMed)

More Proteins for Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) (GZMH) Interaction Partners

Human Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) (GZMH) interaction partners

  1. Granzyme H did directly process DFF45 (show DFFA Proteins), potentially leading to DNA damage.

  2. Upon reactive center loop cleavage at Phe-343,SERPINB1 (show SERPINB1 Proteins) covalently complexes with GzmH. SERPINB1 (show SERPINB1 Proteins) overexpression suppresses GzmH- or LAK (show ARL4C Proteins) cell-mediated cytotoxicity. Crystal structures show possible conformational changes in GzmH for the suicide inhibition.

  3. An unusual RKR (show CACNA1A Proteins) motif (Arg39-Lys40-Arg41), conserved only in GzmH, helps define the S3' and S4' binding regions, indicating the preference for acidic residues at the P3' and P4' sites.

  4. GzmH suppresses viral replication through association with the hepatitis B virus x protein.

  5. Granzyme C rapidly induces target cell death by attacking nuclear and mitochondrial targets and that these targets are distinct from those used by granzyme B to cause classical apoptosis.

  6. granzyme H complements the pro-apoptotic function of granzyme B in human NK cells

  7. Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition.

  8. Expression levels of GzmH in naive natural killer cells and its killing ability support the role of the protease in triggering an alternative cell-death pathway in innate immunity.

  9. GzmH may play an essential role in caspase-dependent pathogen clearance in the innate immunity that may complement the proapoptotic function of GzmB in human NK cells.

  10. Granzyme H could have evolved a proteolytic specificity that both interferes directly with adenovirus replication and prevents the virus from blocking the potent pro-apoptotic activity of granzyme B.

Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) (GZMH) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the granzyme family. Members of this family are highly conserved serine proteases that eliminate transformed cells and virus-infected cells. This protein, which has chymotrypsin-like activity, has a preference for bulky aromatic amino acids at the P1 position and for acidic residues at the P3' and P4' positions. This protein is reported to be constitutively expressed in NK cells and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Gene names and symbols associated with GZMH

  • granzyme H (cathepsin G-like 2, protein h-CCPX) (GZMH)
  • granzyme H (GZMH)
  • CCP-X protein
  • CGL-2 protein
  • CSP-C protein
  • CTLA1 protein
  • CTSGL2 protein
  • GZMH protein

Protein level used designations for GZMH

granzyme H , cytotoxic T-lymphocyte proteinase , cytotoxic T-lymphocyte-associated serine esterase 1 , cytotoxin serine protease-C

617313 Bos taurus
100113476 Felis catus
2999 Homo sapiens
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