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anti-Granzyme K (Granzyme 3, Tryptase II) (GZMK) Antibodies

GZMK product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Additionally we are shipping Granzyme K (Granzyme 3, Tryptase II) Kits (18) and Granzyme K (Granzyme 3, Tryptase II) Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GZMK 14945 O35205
GZMK 29165 P49864
GZMK 3003 P49863
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Top anti-Granzyme K (Granzyme 3, Tryptase II) Antibodies at antibodies-online.com

Showing 10 out of 59 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-GZMK Antibody Titration: 0.2-1 ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated cELISA, FACS, ELISA Specificity testing of GM24C3, GM26E7 andGM6C3. BOSC cells weretransiently transfected withexpression vectors for gran-zyme A, B, K and M as well as an irrelevant protein. Ex-pression of the constructs wastested with an anti-tag mono-clonal antibody (B) Intracellular detection of granzyme K in humanPBMC. Mononuclear cells from peripheral blood (PBMC)were seperated by Ficoll-Hypaque, fixed andpermeabilised. Cells were incubated with hybridomasupernatant of GM24C3, GM26E7 or GM6C3for 30minutes. Bound anti 100 μg Log in to see 5 to 6 Days
$358.05
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Immunohistochemistry analysis of Granzyme K in paraffin-embedded human lung carcinoma tissue. Western blot analysis of Granzyme K antibody in extracts from Jurkat cells. 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IF, IHC (p), ELISA, WB 100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 11 to 13 Days
$365.20
Details
Human Mouse Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 200 μg Log in to see 9 to 11 Days
$387.20
Details

GZMK Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Granzyme K (Granzyme 3, Tryptase II) Antibodies

  1. Human Polyclonal GZMK Primary Antibody for WB - ABIN2782156 : Fajardo, Pejler: Formation of active monomers from tetrameric human beta-tryptase. in The Biochemical journal 2003 (PubMed)

  2. Human Monoclonal GZMK Primary Antibody for cELISA, FACS - ABIN108721 : Bade, Lohrmann, ten Brinke, Wolbink, Wolbink, ten Berge, Virchow, Luttmann, Hack: Detection of soluble human granzyme K in vitro and in vivo. in European journal of immunology 2005 (PubMed)

  3. Human Polyclonal GZMK Primary Antibody for WB - ABIN2782157 : Rucevic, Fast, Jay, Trespalcios, Sucov, Siryaporn, Lim: Altered levels and molecular forms of granzyme k in plasma from septic patients. in Shock (Augusta, Ga.) 2007 (PubMed)

More Antibodies against Granzyme K (Granzyme 3, Tryptase II) Interaction Partners

Mouse (Murine) Granzyme K (Granzyme 3, Tryptase II) (GZMK) interaction partners

  1. The data suggest that T-killer cells control lymphocytic choriomeningitis virus through non-cytotoxic processes that involve gzmK.

  2. It was suggested that a high predisposition to catalepsy in mice can be defined by the Map3k1 (show MAP3K1 Antibodies), Il6st (show IL6ST Antibodies), Gzmk, and Hspb3 (show HSPB3 Antibodies) genes' coexpression network.

  3. GzmK-induced caspase (show CASP3 Antibodies)-independent death occurs through Bid (show BID Antibodies)-dependent mitochondrial damage that is different from GzmA (show GZMA Antibodies)

  4. grzK plays an important role in CD8 (show CD8A Antibodies)(+) T-cell cytotoxicity both in the presence and absence of grzA and B.

Human Granzyme K (Granzyme 3, Tryptase II) (GZMK) interaction partners

  1. Extracellular GrK (show GRK4 Antibodies) is an unexpected direct modulator of lipopolysaccharide-TLR4 (show TLR4 Antibodies) signaling during the antimicrobial innate immune response.

  2. Granzyme K plays an important physiological role in immunoregulation of adaptive immunity underlying the cytotoxicity of CD56 (show NCAM1 Antibodies)(bright) natural killer (NK) cells toward activated T cells.

  3. Gr3 (show PRLHR Antibodies) proenzymes is activated by cathepsin C (show CTSC Antibodies) which concomitantly decreased the molecular weight to that of active Gr3 (show PRLHR Antibodies).

  4. The present findings thus introduce the possibility that human beta-tryptase (show TPSAB1 Antibodies), after mast cell degranulation and exposure to neutral pH in the tissue, may dissociate into active monomers with properties that are distinct from the tetrameric counterpart.

  5. We found human GzmK triggers rapid cell death independently of caspase (show CASP3 Antibodies) activation. The features of death are characterized by rapid externalization of phosphatidylserine, nuclear morphological changes and single-stranded DNA nicks.

  6. GzmK-induced caspase (show CASP3 Antibodies)-independent death occurs through Bid (show BID Antibodies)-dependent mitochondrial damage that is different from GzmA (show GZMA Antibodies)

  7. Rsults indicate that plasma levels of Granzyme K could serve as a useful diagnostic marker to stage sepsis, permitting better classification, specific treatments of patients, and may play a functional role in the development of sepsis.

  8. GrK (show GRK4 Antibodies) not only constitutes a redundant functional backup mechanism that assists GrA (show NR3C1 Antibodies)-induced cell death but that it also displays a unique function by cleaving its own specific substrates.

  9. p53 (show TP53 Antibodies) is as a cytotoxic bomb that can be triggered by granzyme K, leading to potentiating killing efficacy.

Rabbit Granzyme K (Granzyme 3, Tryptase II) (GZMK) interaction partners

  1. Data show that the serum levels of mast cell tryptase, monocyte chemoattractant protein-1 (MCP-1 (show CCL2 Antibodies)) and interleukin-8 (IL-8 (show IL8 Antibodies)) decreased significantly in Dachengqi decoction treatment group.

Granzyme K (Granzyme 3, Tryptase II) (GZMK) Antigen Profile

Protein Summary

This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes.

Gene names and symbols associated with GZMK

  • granzyme K-like (LOC100052126) antibody
  • granzyme K (Gzmk) antibody
  • granzyme K (granzyme 3; tryptase II) (GZMK) antibody
  • granzyme K (granzyme 3; tryptase II) (Gzmk) antibody
  • granzyme K-like (LOC100345938) antibody
  • TRYP2 antibody

Protein level used designations for GZMK

NK-Tryp-2 , NK-tryptase-2 , RNK-Tryp-2 , fragmentin-3 , granzyme 3 , granzyme K , granzyme K (serine protease, granzyme 3; tryptase II) , granzyme-3 , tryptase II

GENE ID SPECIES
100052126 Equus caballus
14945 Mus musculus
29165 Rattus norvegicus
3003 Homo sapiens
100233185 Sus scrofa
426168 Gallus gallus
100727863 Cavia porcellus
100345938 Oryctolagus cuniculus
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