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GZMK product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Additionally we are shipping Granzyme K (Granzyme 3, Tryptase II) Antibodies (58) and Granzyme K (Granzyme 3, Tryptase II) Proteins (9) and many more products for this protein.
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The data suggest that T-killer cells control lymphocytic choriomeningitis virus through non-cytotoxic processes that involve gzmK.
It was suggested that a high predisposition to catalepsy in mice can be defined by the Map3k1 (show MAP3K1 ELISA Kits), Il6st (show IL6ST ELISA Kits), Gzmk, and Hspb3 (show HSPB3 ELISA Kits) genes' coexpression network.
GzmK-induced caspase (show CASP3 ELISA Kits)-independent death occurs through Bid (show BID ELISA Kits)-dependent mitochondrial damage that is different from GzmA (show GZMA ELISA Kits)
grzK plays an important role in CD8 (show CD8A ELISA Kits)(+) T-cell cytotoxicity both in the presence and absence of grzA and B.
Extracellular GrK (show GRK4 ELISA Kits) is an unexpected direct modulator of lipopolysaccharide-TLR4 (show TLR4 ELISA Kits) signaling during the antimicrobial innate immune response.
Granzyme K plays an important physiological role in immunoregulation of adaptive immunity underlying the cytotoxicity of CD56 (show NCAM1 ELISA Kits)(bright) natural killer (NK) cells toward activated T cells.
Gr3 (show PRLHR ELISA Kits) proenzymes is activated by cathepsin C (show CTSC ELISA Kits) which concomitantly decreased the molecular weight to that of active Gr3 (show PRLHR ELISA Kits).
The present findings thus introduce the possibility that human beta-tryptase (show TPSAB1 ELISA Kits), after mast cell degranulation and exposure to neutral pH in the tissue, may dissociate into active monomers with properties that are distinct from the tetrameric counterpart.
We found human GzmK triggers rapid cell death independently of caspase (show CASP3 ELISA Kits) activation. The features of death are characterized by rapid externalization of phosphatidylserine, nuclear morphological changes and single-stranded DNA nicks.
Rsults indicate that plasma levels of Granzyme K could serve as a useful diagnostic marker to stage sepsis, permitting better classification, specific treatments of patients, and may play a functional role in the development of sepsis.
GrK (show GRK4 ELISA Kits) not only constitutes a redundant functional backup mechanism that assists GrA (show NR3C1 ELISA Kits)-induced cell death but that it also displays a unique function by cleaving its own specific substrates.
p53 (show TP53 ELISA Kits) is as a cytotoxic bomb that can be triggered by granzyme K, leading to potentiating killing efficacy.
Data show that the serum levels of mast cell tryptase, monocyte chemoattractant protein-1 (MCP-1 (show CCL2 ELISA Kits)) and interleukin-8 (IL-8 (show IL8 ELISA Kits)) decreased significantly in Dachengqi decoction treatment group.
This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes.
, granzyme 3
, granzyme K
, granzyme K (serine protease, granzyme 3; tryptase II)
, tryptase II