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GZMK product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Additionally we are shipping Granzyme K (Granzyme 3, Tryptase II) Kits (24) and Granzyme K (Granzyme 3, Tryptase II) Proteins (9) and many more products for this protein.
Showing 10 out of 62 products:
Human Monoclonal GZMK Primary Antibody for cELISA, FACS - ABIN108722
Bade, Lohrmann, ten Brinke, Wolbink, Wolbink, ten Berge, Virchow, Luttmann, Hack: Detection of soluble human granzyme K in vitro and in vivo. in European journal of immunology 2005
Human Polyclonal GZMK Primary Antibody for WB - ABIN2782157
Rucevic, Fast, Jay, Trespalcios, Sucov, Siryaporn, Lim: Altered levels and molecular forms of granzyme k in plasma from septic patients. in Shock (Augusta, Ga.) 2007
Horse (Equine) Polyclonal GZMK Primary Antibody for WB - ABIN2782156
Fajardo, Pejler: Formation of active monomers from tetrameric human beta-tryptase. in The Biochemical journal 2003
The data suggest that T-killer cells control lymphocytic choriomeningitis virus through non-cytotoxic processes that involve gzmK.
It was suggested that a high predisposition to catalepsy in mice can be defined by the Map3k1 (show MAP3K1 Antibodies), Il6st (show IL6ST Antibodies), Gzmk, and Hspb3 (show HSPB3 Antibodies) genes' coexpression network.
GzmK-induced caspase (show CASP3 Antibodies)-independent death occurs through Bid (show BID Antibodies)-dependent mitochondrial damage that is different from GzmA (show GZMA Antibodies)
grzK plays an important role in CD8 (show CD8A Antibodies)(+) T-cell cytotoxicity both in the presence and absence of grzA and B.
Extracellular granzyme K mediates endothelial activation through the cleavage of PAR-1 (show MARK2 Antibodies).
Carbamate pesticides significantly reduced the intracellular levels of perforin (show PRF1 Antibodies), GrA (show NR3C1 Antibodies), GrB, Gr3 (show PRLHR Antibodies)/K, and GRN (show GRN Antibodies) in NK-92CI cells.
Extracellular GrK (show GRK4 Antibodies) is an unexpected direct modulator of lipopolysaccharide-TLR4 (show TLR4 Antibodies) signaling during the antimicrobial innate immune response.
Granzyme K plays an important physiological role in immunoregulation of adaptive immunity underlying the cytotoxicity of CD56 (show NCAM1 Antibodies)(bright) natural killer (NK) cells toward activated T cells.
Gr3 (show PRLHR Antibodies) proenzymes is activated by cathepsin C (show CTSC Antibodies) which concomitantly decreased the molecular weight to that of active Gr3 (show PRLHR Antibodies).
The present findings thus introduce the possibility that human beta-tryptase (show TPSAB1 Antibodies), after mast cell degranulation and exposure to neutral pH in the tissue, may dissociate into active monomers with properties that are distinct from the tetrameric counterpart.
We found human GzmK triggers rapid cell death independently of caspase (show CASP3 Antibodies) activation. The features of death are characterized by rapid externalization of phosphatidylserine, nuclear morphological changes and single-stranded DNA nicks.
Rsults indicate that plasma levels of Granzyme K could serve as a useful diagnostic marker to stage sepsis, permitting better classification, specific treatments of patients, and may play a functional role in the development of sepsis.
GrK (show GRK4 Antibodies) not only constitutes a redundant functional backup mechanism that assists GrA (show NR3C1 Antibodies)-induced cell death but that it also displays a unique function by cleaving its own specific substrates.
Data show that the serum levels of mast cell tryptase, monocyte chemoattractant protein-1 (MCP-1 (show CCL2 Antibodies)) and interleukin-8 (IL-8 (show IL8 Antibodies)) decreased significantly in Dachengqi decoction treatment group.
This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes.
, granzyme 3
, granzyme K
, granzyme K (serine protease, granzyme 3; tryptase II)
, tryptase II