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anti-Granzyme M (Lymphocyte Met-Ase 1) (GZMM) Antibodies

Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. Additionally we are shipping GZMM Kits (12) and GZMM Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GZMM 3004 P51124
GZMM 29252  
GZMM 16904  
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Top anti-GZMM Antibodies at antibodies-online.com

Showing 10 out of 40 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of GZMM Antibody (Center) in K562 cell line lysates (35 µg/lane). GZMM (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of GZMM Antibody (Center) (ABIN390763) in K562 cell line lysates (35 µg/lane). GZMM (arrow) was detected using the purified polyclonal antibody. GZMM Antibody (Center) (ABIN390763) IHC analysis in formalin fixed and paraffin embedded human lymph tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (37.73 KDa) . 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of Granzyme M expression in HeLa (A), PC12 (B), NS-1 (C) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Mouse Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$356.40
Details
Rat Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$376.20
Details
Human Mouse Un-conjugated ELISA, WB   0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (38.1 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 11 to 13 Days
$347.60
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB   400 μL Log in to see 8 to 10 Days
$463.83
Details

GZMM Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-GZMM Antibodies

  1. Human Polyclonal GZMM Primary Antibody for EIA, WB - ABIN453082 : Mahrus, Kisiel, Craik: Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B. in The Journal of biological chemistry 2004 (PubMed)

  2. Human Monoclonal GZMM Primary Antibody for ELISA, WB - ABIN516325 : Schiffer, Letzian, Jost, Mladenov, Hristodorov, Huhn, Fischer, Barth, Thepen: Granzyme M as a novel effector molecule for human cytolytic fusion proteins: CD64-specific cytotoxicity of Gm-H22(scFv) against leukemic cells. in Cancer letters 2013 (PubMed)

More Antibodies against GZMM Interaction Partners

Human Granzyme M (Lymphocyte Met-Ase 1) (GZMM) interaction partners

  1. Granzym M may be important in regulating HCMV latency and reactivation in SCT patients.

  2. GrM (show TPST2 Antibodies) is expressed in HCMV-specific CD8thorn T cells and cleaves host cell protein hnRNP K (show HNRNPK Antibodies) in the presence of RNA.

  3. FADD (show FADD Antibodies) cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase (show CASP3 Antibodies) cascade.

  4. Results indicate that cellular overexpression of SERPINB4 (show SERPINB4 Antibodies) inhibits recombinant GrM (show TPST2 Antibodies)-induced as well as NK cell-mediated cell death.

  5. GrM (show TPST2 Antibodies) also exists extracellularly in plasma where it could play a physiological role in controlling blood coagulation by determining plasma FVIII (show F8 Antibodies) levels via proteolytic processing of its carrier VWF (show VWF Antibodies).

  6. Results describe the structural characterization of granzyme M by molecular modeling as well as by detailed comparison with other granzymes.

  7. Noncytotoxic inhibition of cytomegalovirus replication through NK cell protease granzyme M-mediated cleavage of viral phosphoprotein 71.

  8. survivin (show BIRC5 Antibodies) cleavage by Granzyme M triggers degradation of the survivin (show BIRC5 Antibodies)-X-linked inhibitor of apoptosis protein (XIAP (show XIAP Antibodies)) complex to free caspase (show CASP3 Antibodies) activity leading to cytolysis of target tumor cells

  9. These findings support not only a role for GrM (show TPST2 Antibodies) in the innate but also in the adaptive immune response.

  10. granzyme M represents a third major and specialized perforin (show PRF1 Antibodies)-dependent cell death pathway that plays a significant role in death mediated by NK cells

Mouse (Murine) Granzyme M (Lymphocyte Met-Ase 1) (GZMM) interaction partners

  1. Granzyme M regulates the release of natural killer cell MIP-1alpha (show CCL3 Antibodies) to initiate innate immune responses.

  2. Natural killer (NK) cell GrzM augments the inflammatory cascade downstream of lipopolysaccharide (LPS (show TLR4 Antibodies))-toll (show TLR4 Antibodies)-like receptor (TLR)4 (show TLR4 Antibodies) signaling, which ultimately results in lethal endotoxicosis.

GZMM Antigen Profile

Protein Summary

Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with GZMM

  • granzyme M (LOC100136381) antibody
  • granzyme M (lymphocyte met-ase 1) (GZMM) antibody
  • granzyme M (lymphocyte met-ase 1) (Gzmm) antibody
  • Lmet1 antibody
  • MET1 antibody
  • MMET-1 antibody

Protein level used designations for GZMM

granzyme M , HU-Met-1 , Met-1 serine protease , lymphocyte met-ase 1 , met-ase , natural killer cell granular protease , RNK-Met-1 , lymphoctye Met-ase 1

GENE ID SPECIES
100136381 Salmo salar
3004 Homo sapiens
29252 Rattus norvegicus
16904 Mus musculus
100233186 Sus scrofa
Selected quality suppliers for anti-GZMM (GZMM) Antibodies
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