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Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. Additionally we are shipping GZMM Antibodies (40) and GZMM Proteins (9) and many more products for this protein.
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Human GZMM ELISA Kit for Sandwich ELISA - ABIN414663
Bovenschen, Spijkers, Wensink, Schellens, van Domselaar, van Baarle: Elevated granzyme M-expressing lymphocytes during cytomegalovirus latency and reactivation after allogeneic stem cell transplantation. in Clinical immunology (Orlando, Fla.) 2014
Granzym M may be important in regulating HCMV latency and reactivation in SCT patients.
GrM (show TPST2 ELISA Kits) is expressed in HCMV-specific CD8thorn T cells and cleaves host cell protein hnRNP K (show HNRNPK ELISA Kits) in the presence of RNA.
FADD (show FADD ELISA Kits) cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase (show CASP3 ELISA Kits) cascade.
Results indicate that cellular overexpression of SERPINB4 (show SERPINB4 ELISA Kits) inhibits recombinant GrM (show TPST2 ELISA Kits)-induced as well as NK cell-mediated cell death.
GrM (show TPST2 ELISA Kits) also exists extracellularly in plasma where it could play a physiological role in controlling blood coagulation by determining plasma FVIII (show F8 ELISA Kits) levels via proteolytic processing of its carrier VWF (show VWF ELISA Kits).
Results describe the structural characterization of granzyme M by molecular modeling as well as by detailed comparison with other granzymes.
Noncytotoxic inhibition of cytomegalovirus replication through NK cell protease granzyme M-mediated cleavage of viral phosphoprotein 71.
survivin (show BIRC5 ELISA Kits) cleavage by Granzyme M triggers degradation of the survivin (show BIRC5 ELISA Kits)-X-linked inhibitor of apoptosis protein (XIAP (show XIAP ELISA Kits)) complex to free caspase (show CASP3 ELISA Kits) activity leading to cytolysis of target tumor cells
These findings support not only a role for GrM (show TPST2 ELISA Kits) in the innate but also in the adaptive immune response.
granzyme M represents a third major and specialized perforin (show PRF1 ELISA Kits)-dependent cell death pathway that plays a significant role in death mediated by NK cells
Granzyme M regulates the release of natural killer cell MIP-1alpha (show CCL3 ELISA Kits) to initiate innate immune responses.
Natural killer (NK) cell GrzM augments the inflammatory cascade downstream of lipopolysaccharide (LPS (show TLR4 ELISA Kits))-toll (show TLR4 ELISA Kits)-like receptor (TLR)4 (show TLR4 ELISA Kits) signaling, which ultimately results in lethal endotoxicosis.
Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene.
, Met-1 serine protease
, lymphocyte met-ase 1
, natural killer cell granular protease
, lymphoctye Met-ase 1