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Granzyme M (Lymphocyte Met-Ase 1) Proteins (GZMM)

Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. Additionally we are shipping GZMM Antibodies (41) and GZMM Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GZMM 3004 P51124
GZMM 29252  
GZMM 16904  
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Top GZMM Proteins at antibodies-online.com

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Rat His tag,GST tag 100 μg Log in to see 11 to 13 Days
$792.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 11 to 13 Days
$827.20
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$862.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 9 to 19 Days
$967.75
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$999.22
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$1,030.69
Details

GZMM Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Rat (Rattus)

Mouse (Murine)

More Proteins for Granzyme M (Lymphocyte Met-Ase 1) (GZMM) Interaction Partners

Human Granzyme M (Lymphocyte Met-Ase 1) (GZMM) interaction partners

  1. Granzym M may be important in regulating HCMV latency and reactivation in SCT patients.

  2. GrM (show TPST2 Proteins) is expressed in HCMV-specific CD8thorn T cells and cleaves host cell protein hnRNP K (show HNRNPK Proteins) in the presence of RNA.

  3. FADD (show FADD Proteins) cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase (show CASP3 Proteins) cascade.

  4. Results indicate that cellular overexpression of SERPINB4 (show SERPINB4 Proteins) inhibits recombinant GrM (show TPST2 Proteins)-induced as well as NK cell-mediated cell death.

  5. GrM (show TPST2 Proteins) also exists extracellularly in plasma where it could play a physiological role in controlling blood coagulation by determining plasma FVIII (show F8 Proteins) levels via proteolytic processing of its carrier VWF (show VWF Proteins).

  6. Results describe the structural characterization of granzyme M by molecular modeling as well as by detailed comparison with other granzymes.

  7. Noncytotoxic inhibition of cytomegalovirus replication through NK cell protease granzyme M-mediated cleavage of viral phosphoprotein 71.

  8. survivin (show BIRC5 Proteins) cleavage by Granzyme M triggers degradation of the survivin (show BIRC5 Proteins)-X-linked inhibitor of apoptosis protein (XIAP (show XIAP Proteins)) complex to free caspase (show CASP3 Proteins) activity leading to cytolysis of target tumor cells

  9. These findings support not only a role for GrM (show TPST2 Proteins) in the innate but also in the adaptive immune response.

  10. granzyme M represents a third major and specialized perforin (show PRF1 Proteins)-dependent cell death pathway that plays a significant role in death mediated by NK cells

Mouse (Murine) Granzyme M (Lymphocyte Met-Ase 1) (GZMM) interaction partners

  1. Granzyme M regulates the release of natural killer cell MIP-1alpha (show CCL3 Proteins) to initiate innate immune responses.

  2. Natural killer (NK) cell GrzM augments the inflammatory cascade downstream of lipopolysaccharide (LPS (show TLR4 Proteins))-toll (show TLR4 Proteins)-like receptor (TLR)4 (show TLR4 Proteins) signaling, which ultimately results in lethal endotoxicosis.

GZMM Protein Profile

Protein Summary

Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with GZMM

  • granzyme M (LOC100136381)
  • granzyme M (lymphocyte met-ase 1) (GZMM)
  • granzyme M (lymphocyte met-ase 1) (Gzmm)
  • Lmet1 protein
  • MET1 protein
  • MMET-1 protein

Protein level used designations for GZMM

granzyme M , HU-Met-1 , Met-1 serine protease , lymphocyte met-ase 1 , met-ase , natural killer cell granular protease , RNK-Met-1 , lymphoctye Met-ase 1

GENE ID SPECIES
100136381 Salmo salar
3004 Homo sapiens
29252 Rattus norvegicus
16904 Mus musculus
100233186 Sus scrofa
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