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Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. Additionally we are shipping GZMM Kits (17) and GZMM Proteins (9) and many more products for this protein.
Showing 10 out of 41 products:
Human Polyclonal GZMM Primary Antibody for EIA, WB - ABIN453082
Mahrus, Kisiel, Craik: Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B. in The Journal of biological chemistry 2004
Human Monoclonal GZMM Primary Antibody for ELISA, WB - ABIN516325
Schiffer, Letzian, Jost, Mladenov, Hristodorov, Huhn, Fischer, Barth, Thepen: Granzyme M as a novel effector molecule for human cytolytic fusion proteins: CD64-specific cytotoxicity of Gm-H22(scFv) against leukemic cells. in Cancer letters 2013
Granzym M may be important in regulating HCMV latency and reactivation in SCT patients.
GrM (show TPST2 Antibodies) is expressed in HCMV-specific CD8thorn T cells and cleaves host cell protein hnRNP K (show HNRNPK Antibodies) in the presence of RNA.
FADD (show FADD Antibodies) cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase (show CASP3 Antibodies) cascade.
Results indicate that cellular overexpression of SERPINB4 (show SERPINB4 Antibodies) inhibits recombinant GrM (show TPST2 Antibodies)-induced as well as NK cell-mediated cell death.
GrM (show TPST2 Antibodies) also exists extracellularly in plasma where it could play a physiological role in controlling blood coagulation by determining plasma FVIII (show F8 Antibodies) levels via proteolytic processing of its carrier VWF (show VWF Antibodies).
Results describe the structural characterization of granzyme M by molecular modeling as well as by detailed comparison with other granzymes.
Noncytotoxic inhibition of cytomegalovirus replication through NK cell protease granzyme M-mediated cleavage of viral phosphoprotein 71.
survivin (show BIRC5 Antibodies) cleavage by Granzyme M triggers degradation of the survivin (show BIRC5 Antibodies)-X-linked inhibitor of apoptosis protein (XIAP (show XIAP Antibodies)) complex to free caspase (show CASP3 Antibodies) activity leading to cytolysis of target tumor cells
These findings support not only a role for GrM (show TPST2 Antibodies) in the innate but also in the adaptive immune response.
granzyme M represents a third major and specialized perforin (show PRF1 Antibodies)-dependent cell death pathway that plays a significant role in death mediated by NK cells
Granzyme M regulates the release of natural killer cell MIP-1alpha (show CCL3 Antibodies) to initiate innate immune responses.
Natural killer (NK) cell GrzM augments the inflammatory cascade downstream of lipopolysaccharide (LPS (show TLR4 Antibodies))-toll (show TLR4 Antibodies)-like receptor (TLR)4 (show TLR4 Antibodies) signaling, which ultimately results in lethal endotoxicosis.
Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene.
, Met-1 serine protease
, lymphocyte met-ase 1
, natural killer cell granular protease
, lymphoctye Met-ase 1