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Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. Additionally we are shipping GZMM Antibodies (40) and GZMM Kits (17) and many more products for this protein.
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We also report that TNFalpha induces the attachment of Met1-linked Ub chains directly to TNF receptor 1, which do not seem to be attached covalently to Lys63-linked or other types of ubiquitin chain.
Granzym M may be important in regulating HCMV latency and reactivation in SCT patients.
GrM (show TPST2 Proteins) is expressed in HCMV-specific CD8thorn T cells and cleaves host cell protein hnRNP K (show HNRNPK Proteins) in the presence of RNA.
FADD (show FADD Proteins) cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase (show CASP3 Proteins) cascade.
Results indicate that cellular overexpression of SERPINB4 (show SERPINB4 Proteins) inhibits recombinant GrM (show TPST2 Proteins)-induced as well as NK cell-mediated cell death.
GrM (show TPST2 Proteins) also exists extracellularly in plasma where it could play a physiological role in controlling blood coagulation by determining plasma FVIII (show F8 Proteins) levels via proteolytic processing of its carrier VWF (show VWF Proteins).
Results describe the structural characterization of granzyme M by molecular modeling as well as by detailed comparison with other granzymes.
Noncytotoxic inhibition of cytomegalovirus replication through NK cell protease granzyme M-mediated cleavage of viral phosphoprotein 71.
survivin (show BIRC5 Proteins) cleavage by Granzyme M triggers degradation of the survivin (show BIRC5 Proteins)-X-linked inhibitor of apoptosis protein (XIAP (show XIAP Proteins)) complex to free caspase (show CASP3 Proteins) activity leading to cytolysis of target tumor cells
These findings support not only a role for GrM (show TPST2 Proteins) in the innate but also in the adaptive immune response.
Granzyme M regulates the release of natural killer cell MIP-1alpha (show CCL3 Proteins) to initiate innate immune responses.
Natural killer (NK) cell GrzM augments the inflammatory cascade downstream of lipopolysaccharide (LPS (show TLR4 Proteins))-toll (show TLR4 Proteins)-like receptor (TLR)4 (show TLR4 Proteins) signaling, which ultimately results in lethal endotoxicosis.
Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene.
, Met-1 serine protease
, lymphocyte met-ase 1
, natural killer cell granular protease
, lymphoctye Met-ase 1