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Growth arrest-specific 1 plays a role in growth suppression. Additionally we are shipping GAS1 Antibodies (33) and GAS1 Kits (4) and many more products for this protein.
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the overexpression of Gas1 (growth arrest specific 1) gene reduces the size, proliferating activity and malignancy of liver tumors.
WT1 (show WT1 Proteins) modulates receptor tyrosine kinase (show ERBB3 Proteins) signaling in nephron progenitor cell by directing the expression of Gas1.
When Shh (show SHH Proteins) is presented as a point source, enteric axons turn away from it in a Gas1-dependent manner.
widespread distribution and cellular localization of the GAS1 native protein in adult mammalian CNS
finding that Gas1 is transcribed at the G(1)/S transition suggests that the gene may exert a novel function during cell proliferation.
Gas1 promotes myogenic differentiation through regulation of cell cycle arrest and is critical to activate p38MAPK (show MAPK14 Proteins)
Genetic loss-of-function of GAS1, CDO (show CDO1 Proteins), and BOC (show BOC Proteins) in SHH (show SHH Proteins) is associated with defective neural patterning.
Gas1 acts to maintain high levels of FGF10 (show FGF10 Proteins) at the tip mesenchyme and support the proposal that Fgf10 (show FGF10 Proteins) expression in this region is crucial for maintaining Fgf8 (show FGF8 Proteins) expression in the AER
Gas1 is related to the GDNF (show GDNF Proteins) alpha receptors and regulates Ret (show RET Proteins) signaling
GAS1 acts cooperatively with Patched1 (show PTCH1 Proteins) for Hedgehog (show SHH Proteins) binding and enhances signaling activity in a cell-autonomous manner.
solutions structure and biophysical characterization of the multifaceted signalling effector protein growth arrest specific-1
This review summarizes the structure of Gas1 and molecular mechanism of action during embryonic development and cellular functions.
GAS1 is a novel endogenous inhibitor of glomerular mesangial cell proliferation.
Growth arrest-specific gene 1 is downregulated and inhibits tumor growth in gastric cancer.
GAS1 induced the activity of caspase-3 (show CASP3 Proteins) and resulting in apoptosis of the cells.
Interference of endoplasmic reticulum to Golgi transport increased immature amyloid beta protein precursor accumulation upon Gas1 expression in lipid raft fractions.
we demonstrate that sequence variants in GAS1 can impair its physical interaction with SHH (show SHH Proteins), suggesting a decrease in the SHH (show SHH Proteins) downstream signaling cascade as a pathogenic mechanism of disease.
Gas1 is a novel APP (show APP Proteins)-interacting protein involved in the control of APP (show APP Proteins) maturation and processing.
Growth arrest-specific gene 1 contributes to predicting metastasis or recurrence in stage II and III colorectal cancer.
GAS1 could be considered a candidate locus for one of the types of human holoprosencephaly.
Growth arrest-specific 1 plays a role in growth suppression. GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene.
growth arrest-specific 1
, growth arrest-specific protein 1
, Growth arrest-specific gene-1
, growth arrest-specific protein 1-like