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Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. Additionally we are shipping GAS7 Antibodies (94) and GAS7 Proteins (16) and many more products for this protein.
Forced expression of Gas7a or Gas7b isoform in mouse neuroblastoma Neuro2A cells, which express a defective Gas7 gene, rendered the cells proapoptotic and vulnerable to cisplatin-induced apoptosis.
Gas7 works through its interaction with N-WASP (show WASL ELISA Kits) during neuronal maturation/ differentiation
Gas7 in PC12 cells leads to an expanded cell morphology and promotes neurite formation. These processes undergo elongation upon addition of nerve growth factor (NGF).
Hoxa7 (show HOXA7 ELISA Kits) and Hoxa9 (show HOXA9 ELISA Kits) contribute to hematopoietic progenitor homeostasis but are not necessary for MLL-GAS7-mediated leukemogenesis
The ability of gas7 to potentiate neuronal differentiation makes it a potential therapeutic target to promote re-establishment of neuronal connections in the injured or diseased brain, such as following stroke.
Our data reveal that Gas7 might play a role in cellular migration and cell protection in the ES cells of mouse embryo.
These results suggest that Gas7 enhances microtubule polymerization by stabilizing sheet intermediates and is a useful tool for analyzing microtubule transformation.
Low GAS7C increases cancer cell motility by promoting N-WASP (show WASL ELISA Kits)/FAK (show PTK2 ELISA Kits)/F-actin cytoskeleton dynamics. It also enhances beta-catenin (show CTNNB1 ELISA Kits) stability via hnRNP U (show HNRNPU ELISA Kits)/beta-TrCP (show BTRC ELISA Kits) complex formation.
These findings indicate that Gas7 is involved in motor neuron function associated with muscle strength maintenance.
Intraocular pressure (IOP)was significantly associated with rs11656696, located in GAS7 at 17p13.1 and with rs7555523, located in TMCO1 (show TMCO1 ELISA Kits) at 1q24.1.These data suggest that we have identified two clinically relevant genes involved in IOP regulation.
regulates the differentiation of mesenchymal stem cells into osteoblasts by enhancing Runx2 (show RUNX2 ELISA Kits)-dependent gene expression
Knockdown of Gas7 by shRNA preferentially suppressed the Gas7b protein isoform in human preneuronal cells and to reduce apoptosis induced either by serum starvation or by the antineoplastic agents in human neuroblastoma (show ARHGEF16 ELISA Kits) SH-SY5Y cells.
This work reports the identification of two human Gas7 cDNA: hGas7-a with 2,427 nucleotides, which encodes 330 amino acids, and hGas7-b with 2,610 nucleotides, which encodes 412 amino acids according to predicted open-reading-frames.
Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described.
growth arrest-specific 7
, growth arrest-specific protein 7-like
, growth arrest-specific protein 7
, MLL/GAS7 fusion protein
, growth arrest specific 7