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The protein encoded by GDF11 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. Additionally we are shipping GDF11 Antibodies (50) and GDF11 Kits (47) and many more products for this protein.
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First non-mammalian growth/differentiation factor (GDF) 11-like homolog was cloned from zebrafish. Sequencing,phylogenetic analysis,tissue expression, and mRNA levels during embryonic development are reported.
The crystal structure of GDF11 was determined to a resolution of 1.50 A.
GDF11 is essential for mammalian development and has been suggested to regulate aging of multiple tissues. It functions in the heart, skeletal muscle, and brain. Review.
GDF11 inhibits rather than helps muscle regeneration.
Show that there is no age-related cardiac hypertrophy in disease-free 24-month-old C57BL/6 mice and that restoring GDF11 in old mice has no effect on cardiac structure or function.
in vitro sprout formation was increased as well by GDF11 treatment
Suggest GDF11 functions as encephalic regionalizing factor in neural differentiated mouse embryonic stem cells.
GDF11 is a critical rheostat for bone turnover and a key integrator of bone homeostasis.
These data demonstrate GDF11 to be a master regulator of neural stem cell transcription that can suppress cell proliferation and migration by regulating the expression of numerous genes involved in both these processes
Expression of GDF11, a cytokine which blocks terminal erythroid maturation, was increased in erthyroblasts of thalassemic patients.
Quantitative real-time reverse transcription-PCR in colorectal cancer specimens obtained from 130 patients showed that GDF11 mRNA expression in cancer tissue was significantly higher than in normal tissue
Circulating levels of GDF11/8 declines with age in mice (and sheep, horses and rats).
Data show that circulating myostatin (show MSTN Proteins) levels decreased with age and estimates of growth differentiation factor 11 (GDF11) levels using myostatin (show MSTN Proteins) null mice indicate that they were almost 500 times lower than those for myostatin (show MSTN Proteins).
Two new studies demonstrate that GDF11 this "factor of youth" rejuvenates stem cells found in the skeletal muscle and brain of aged mice.
Therefore, we postulate that GDF (show GDF5 Proteins)-11DeltaEx1 may act as a long non-coding RNA to regulate the transcription of canonical GDF-11 and/or other genes in skeletal muscle and other tissues
Expression of GDF11, a cytokine which blocks terminal erythroid maturation, was increased in erthyroblasts of thalassemic mice.
GDF11 inhibited erythroid maturation in mice in vivo and ex vivo. Expression of GDF11 in erythroid precursors decreased progressively with maturation, suggesting an inhibitory role for GDF11 in late-stage erythroid differentiation.
Gdf11 stimulates expression of a Hoxd11 (show HOXD11 Proteins)/lacZ (show GLB1 Proteins) transgene in the mouse embryo tailbud.
GASP-1 (show GPRASP1 Proteins) and GASP-2 (show WFIKKN1 Proteins) are important modulators of GDF-11 and MSTN (show MSTN Proteins) activity in vivo.
Gdf11 signaling is a major coordinator of the trunk-to-tail transition during mouse development
Using modified aptamer-based proteomics, study identified the TGF-beta (show TGFB1 Proteins) superfamily member GDF11 as a circulating factor in young mice that declines with age.
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development.
growth/differentiation factor 11
, growth differentiation factor 11
, bone morphogenetic protein 11