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The protein encoded by GDF11 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. Additionally we are shipping GDF11 Kits (67) and GDF11 Proteins (23) and many more products for this protein.
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First non-mammalian growth/differentiation factor (GDF) 11-like homolog was cloned from zebrafish. Sequencing,phylogenetic analysis,tissue expression, and mRNA levels during embryonic development are reported.
These studies identify distinctive structural features of GDF11 that enhance its potency, relative to GDF8 (show MSTN Antibodies); however, the biological consequences of these differences remain to be determined.
In elderly Chinese women, osteoporosis risk was significantly increased with increases in GDF11 serum levels.
A Prodomain Fragment from the Proteolytic Activation of Growth Differentiation Factor 11 Remains Associated with the Mature Growth Factor and Keeps It Soluble
MSTN (show MSTN Antibodies), but not GDF11, declines in healthy men throughout aging.
GDF11 is highly concentrated in human platelets.
The crystal structure of GDF11 was determined to a resolution of 1.50 A.
GDF11 is essential for mammalian development and has been suggested to regulate aging of multiple tissues. It functions in the heart, skeletal muscle, and brain. Review.
GDF11 inhibits rather than helps muscle regeneration.
Show that there is no age-related cardiac hypertrophy in disease-free 24-month-old C57BL/6 mice and that restoring GDF11 in old mice has no effect on cardiac structure or function.
in vitro sprout formation was increased as well by GDF11 treatment
In conclusion, our findings show that GDF11 expression declines with age and the protective effects of ultrasound-targeted microbubble destruction-mediated delivery of GDF11 on the aged ischemic heart provide support for the classification of GDF11 as an anti-aging factor
we found that myostatin (show MSTN Antibodies) forms a complex with LTBP4 (show LTBP4 Antibodies) and that overexpression of LTBP4 (show LTBP4 Antibodies) led to a decrease in myostatin (show MSTN Antibodies) levels. LTBP4 (show LTBP4 Antibodies) also interacted with TGFbeta (show TGFB1 Antibodies) and GDF11, a protein highly related to myostatin (show MSTN Antibodies). These data identify LTBP4 (show LTBP4 Antibodies) as a multi-TGFbeta (show TGFB1 Antibodies) family ligand binding protein with the capacity to modify muscle disease through overexpression
Circulating levels of GDF11/8 declines with age in mice (and sheep, horses and rats).
Data show that circulating myostatin (show MSTN Antibodies) levels decreased with age and estimates of growth differentiation factor 11 (GDF11) levels using myostatin (show MSTN Antibodies) null mice indicate that they were almost 500 times lower than those for myostatin (show MSTN Antibodies).
Two new studies demonstrate that GDF11 this "factor of youth" rejuvenates stem cells found in the skeletal muscle and brain of aged mice.
Therefore, we postulate that GDF (show GDF5 Antibodies)-11DeltaEx1 may act as a long non-coding RNA to regulate the transcription of canonical GDF-11 and/or other genes in skeletal muscle and other tissues
Expression of GDF11, a cytokine which blocks terminal erythroid maturation, was increased in erthyroblasts of thalassemic mice.
GDF11 inhibited erythroid maturation in mice in vivo and ex vivo. Expression of GDF11 in erythroid precursors decreased progressively with maturation, suggesting an inhibitory role for GDF11 in late-stage erythroid differentiation.
Gdf11 stimulates expression of a Hoxd11 (show HOXD11 Antibodies)/lacZ (show GLB1 Antibodies) transgene in the mouse embryo tailbud.
GASP-1 (show GPRASP1 Antibodies) and GASP-2 (show WFIKKN1 Antibodies) are important modulators of GDF-11 and MSTN (show MSTN Antibodies) activity in vivo.
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development.
, bone morphogenetic protein 11
, growth/differentiation factor 11
, growth differentiation factor 11