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The protein encoded by GDF11 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. Additionally we are shipping GDF11 Antibodies (54) and GDF11 Proteins (23) and many more products for this protein.
Showing 10 out of 67 products:
Mouse (Murine) GDF11 ELISA Kit for Sandwich ELISA - ABIN425326
Wang, Shen, Li, Chen, Wang, Qin, Zhou, Peng, Feng, Li, Liang: Splenocytes derived from young WT mice prevent AD progression in APPswe/PSENldE9 transgenic mice. in Oncotarget 2015
Show all 2 Pubmed References
Rat (Rattus) GDF11 ELISA Kit for Sandwich ELISA - ABIN840607
Bickford, Kaneko, Grimmig, Pappas, Small, Sanberg, Sanberg, Tan, Douglas Shytle: Nutraceutical intervention reverses the negative effects of blood from aged rats on stem cells. in Age (Dordrecht, Netherlands) 2015
Tumor-suppressor inactivation of GDF11 occurs by precursor sequestration in triple-negative breast cancer
These studies identify distinctive structural features of GDF11 that enhance its potency, relative to GDF8 (show MSTN ELISA Kits); however, the biological consequences of these differences remain to be determined.
In elderly Chinese women, osteoporosis risk was significantly increased with increases in GDF11 serum levels.
A Prodomain Fragment from the Proteolytic Activation of Growth Differentiation Factor 11 Remains Associated with the Mature Growth Factor and Keeps It Soluble
MSTN (show MSTN ELISA Kits), but not GDF11, declines in healthy men throughout aging.
GDF11 is highly concentrated in human platelets.
The crystal structure of GDF11 was determined to a resolution of 1.50 A.
GDF11 is essential for mammalian development and has been suggested to regulate aging of multiple tissues. It functions in the heart, skeletal muscle, and brain. Review.
GDF11 inhibits rather than helps muscle regeneration.
Show that there is no age-related cardiac hypertrophy in disease-free 24-month-old C57BL/6 mice and that restoring GDF11 in old mice has no effect on cardiac structure or function.
In conclusion, our findings show that GDF11 expression declines with age and the protective effects of ultrasound-targeted microbubble destruction-mediated delivery of GDF11 on the aged ischemic heart provide support for the classification of GDF11 as an anti-aging factor
we found that myostatin (show MSTN ELISA Kits) forms a complex with LTBP4 (show LTBP4 ELISA Kits) and that overexpression of LTBP4 (show LTBP4 ELISA Kits) led to a decrease in myostatin (show MSTN ELISA Kits) levels. LTBP4 (show LTBP4 ELISA Kits) also interacted with TGFbeta (show TGFB1 ELISA Kits) and GDF11, a protein highly related to myostatin (show MSTN ELISA Kits). These data identify LTBP4 (show LTBP4 ELISA Kits) as a multi-TGFbeta (show TGFB1 ELISA Kits) family ligand binding protein with the capacity to modify muscle disease through overexpression
Circulating levels of GDF11/8 declines with age in mice (and sheep, horses and rats).
Data show that circulating myostatin (show MSTN ELISA Kits) levels decreased with age and estimates of growth differentiation factor 11 (GDF11) levels using myostatin (show MSTN ELISA Kits) null mice indicate that they were almost 500 times lower than those for myostatin (show MSTN ELISA Kits).
Two new studies demonstrate that GDF11 this "factor of youth" rejuvenates stem cells found in the skeletal muscle and brain of aged mice.
Therefore, we postulate that GDF (show GDF5 ELISA Kits)-11DeltaEx1 may act as a long non-coding RNA to regulate the transcription of canonical GDF-11 and/or other genes in skeletal muscle and other tissues
Expression of GDF11, a cytokine which blocks terminal erythroid maturation, was increased in erthyroblasts of thalassemic mice.
GDF11 inhibited erythroid maturation in mice in vivo and ex vivo. Expression of GDF11 in erythroid precursors decreased progressively with maturation, suggesting an inhibitory role for GDF11 in late-stage erythroid differentiation.
Gdf11 stimulates expression of a Hoxd11 (show HOXD11 ELISA Kits)/lacZ (show GLB1 ELISA Kits) transgene in the mouse embryo tailbud.
GASP-1 (show GPRASP1 ELISA Kits) and GASP-2 (show WFIKKN1 ELISA Kits) are important modulators of GDF-11 and MSTN (show MSTN ELISA Kits) activity in vivo.
First non-mammalian growth/differentiation factor (GDF) 11-like homolog was cloned from zebrafish. Sequencing,phylogenetic analysis,tissue expression, and mRNA levels during embryonic development are reported.
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development.
, bone morphogenetic protein 11
, growth/differentiation factor 11
, growth differentiation factor 11