Growth Differentiation Factor 15 Proteins (GDF15)

Bone morphogenetic proteins (e.g., BMP9\; MIM 605120) are members of the transforming growth factor-beta (see TGFB1\; MIM 190180) superfamily and regulate tissue differentiation and maintenance. Additionally we are shipping GDF15 Antibodies (281) and GDF15 Kits (79) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GDF15 9518 Q99988
GDF15 23886 Q9Z0J7
GDF15 29455 Q9Z0J6
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Top GDF15 Proteins at antibodies-online.com

Showing 10 out of 41 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human Fc Tag 50 μg Log in to see 20 to 21 Days
$272.80
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 2 to 3 Days
$525.00
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$583.00
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Cell culture Human Un-conjugated Validation with Western Blot 20 μg Log in to see 12 to 15 Days
$460.85
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 18 Days
$608.00
Details
HOST_Mammalian Cells Mouse His tag   50 μg Log in to see 4 Days
$548.63
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$784.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 4 to 6 Days
$467.87
Details

GDF15 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , ,
, , ,
Mouse (Murine) , , ,

Rat (Rattus)

Top referenced GDF15 Proteins

  1. Human GDF15 Protein expressed in Human Cells - ABIN2003620 : Bauskin, Zhang, Fairlie, He, Russell, Moore, Brown, Stanley, Breit: The propeptide of macrophage inhibitory cytokine (MIC-1), a TGF-beta superfamily member, acts as a quality control determinant for correctly folded MIC-1. in The EMBO journal 2000 (PubMed)
    Show all 2 references for 2003620

  2. Human GDF15 Protein expressed in Escherichia coli (E. coli) - ABIN666670 : Hsiao, Koniaris, Zimmers-Koniaris, Sebald, Huynh, Lee: Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury. in Molecular and cellular biology 2000 (PubMed)
    Show all 2 references for 666670

  3. Human GDF15 Protein expressed in Escherichia coli (E. coli) - ABIN809751 : Matsukawa, Hirooka, Ito, Sunagawa: Inhibition of neuregulin-1/ErbB signaling in the rostral ventrolateral medulla leads to hypertension through reduced nitric oxide synthesis. in American journal of hypertension 2013 (PubMed)

More Proteins for Growth Differentiation Factor 15 (GDF15) Interaction Partners

Human Growth Differentiation Factor 15 (GDF15) interaction partners

  1. PPIX concentrations correlated with both growth differentiation factor (GDF) 15 (p = 0.012) and male gender (p = 0.015).

  2. Data show that growth differentiation factor 15 (GDF15) knockdown significantly inhibited the growth and metastasis of cancer stem-like sphere cells (SCs (show TWIST1 Proteins)) through AKT (show AKT1 Proteins)/GSK-3beta/beta-catenin (show CTNNB1 Proteins) pathway suppression.

  3. epithelial restitution was promoted by enhanced NAG-1 expression and subsequent enterocyte locomotion during the early wound-healing process

  4. serum GDF15 may be a useful diagnostic and prognostic biomarker for colorectal cancer.

  5. These findings highlight an important contribution of GDF15 in promoting airway epithelial senescence upon cigarette smoke exposure.

  6. The results of this study, including a robust induction of GDF-15 expression by several external factors known to elevate IOP, and rGDF-15-induced increase in contractility, cell adhesion, and the levels of ECM (show MMRN1 Proteins) proteins and alphaSMA (show ACTA2 Proteins) in TM cells

  7. GDF-15 captures distinct aspects of cardiovascular disease development, progression, and prognosis, which are not represented by clinical risk predictors and other biomarkers. The usefulness of GDF-15 to guide management decisions and discover new treatment targets should be further explored.

  8. In stable Coronary Heart Disease, GDF-15 was independently associated with cardiovascular (CV), non-CV, and cancer mortality, as well as with MI and stroke. When also adjusting for other prognostic biomarkers, the associations to all fatal and nonfatal events were maintained except for MI. Information on GDF-15, therefore, might be helpful when assessing the risk of adverse outcomes in patients with stable CHD (show CHDH Proteins).

  9. Impaired glucose tolerance is associated with increased GDF-15 levels even in the absence of anemia

  10. GDF15 is a potent mitohormetic signal that safeguards against the onset of obesity and insulin (show INS Proteins) resistance.

Mouse (Murine) Growth Differentiation Factor 15 (GDF15) interaction partners

  1. This is the first study defining the role of Mic-1/Gdf15 in a number of behavioural domains.

  2. epithelial restitution was promoted by enhanced NAG-1 expression and subsequent enterocyte locomotion during the early wound-healing process

  3. both GDF-15 and TGF-beta1 (show TGFB1 Proteins) counteract chemokine (show CCL1 Proteins)-induced integrin activation on neutrophils via the ALK-5 (show TGFBR1 Proteins)/TGF-betaRII heterodimer.

  4. GDF15 is a potent mitohormetic signal that safeguards against the onset of obesity and insulin (show INS Proteins) resistance.

  5. The aim of this study was to identify the role of endogenous Gdf-15 in the MPTP (show PTPN2 Proteins) (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson's disease (PD) by comparing Gdf-15 (+/+) and Gdf-15 (-/-) mice.

  6. The results of this study indicated the importance of Gdf-15 in promoting survival of DAergic neurons and regulating the inflammatory response post 6-OHDA lesion.

  7. endogenous Growth/differentiation factor-15 is beneficial for axon regeneration following sciatic nerve crush

  8. repeated cisterna magna administration of human umbilical cord blood-derived mesenchymal stem cells enhanced endogenous adult hippocampal neurogenesis and synaptic activity through a paracrine factor of GDF-15

  9. Levels of GDF-15 mRNA increased 2 h after induction of ventilator-induced lung injury in WT lungs. Non-hematopoietic cells are the main source of GDF-15. GDF-15 is required for platelet-leukocyte interactions during ventilator-induced lung injury.

  10. hNAG-1 appears to be a novel therapeutic target in preventing and treating obesity and insulin (show INS Proteins) resistance.

GDF15 Protein Profile

Protein Summary

Bone morphogenetic proteins (e.g., BMP9\; MIM 605120) are members of the transforming growth factor-beta (see TGFB1\; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein.

Gene names and symbols associated with GDF15

  • growth differentiation factor 15 (GDF15)
  • growth differentiation factor 15 (Gdf15)
  • GDF-15 protein
  • GDF15 protein
  • MIC-1 protein
  • MIC1 protein
  • NAG-1 protein
  • PDF protein
  • PLAB protein
  • PTGFB protein
  • SBF protein

Protein level used designations for GDF15

growth differentiation factor 15 , NRG-1 , NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1 , NSAID-activated gene 1 protein , NSAID-regulated gene 1 protein , PTGF-beta , growth/differentiation factor 15 , macrophage inhibitory cytokine 1 , placental TGF-beta , placental bone morphogenetic protein , prostate differentiation factor , GDF-15 , macrophage inhibiting cytokine-1

GENE ID SPECIES
719466 Macaca mulatta
9518 Homo sapiens
23886 Mus musculus
29455 Rattus norvegicus
468770 Pan troglodytes
100718010 Cavia porcellus
100379630 Sus scrofa
484822 Canis lupus familiaris
618677 Bos taurus
100913168 Ovis aries
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