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The protein encoded by GDF2 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. Additionally we are shipping GDF2 Kits (74) and GDF2 Proteins (21) and many more products for this protein.
Showing 10 out of 74 products:
Human Polyclonal GDF2 Primary Antibody for IHC (p), WB - ABIN388817
Herrera, van Dinther, Ten Dijke, Inman: Autocrine bone morphogenetic protein-9 signals through activin receptor-like kinase-2/Smad1/Smad4 to promote ovarian cancer cell proliferation. in Cancer research 2009
Show all 5 references for ABIN388817
Human Polyclonal GDF2 Primary Antibody for EIA, IHC (p) - ABIN357458
Majumdar, Wang, Morris: BMP-2 and BMP-9 promotes chondrogenic differentiation of human multipotential mesenchymal cells and overcomes the inhibitory effect of IL-1. in Journal of cellular physiology 2001
Show all 3 references for ABIN357458
Chicken Polyclonal GDF2 Primary Antibody for WB - ABIN2786157
David, Mallet, Keramidas, Lamandé, Gasc, Dupuis-Girod, Plauchu, Feige, Bailly: Bone morphogenetic protein-9 is a circulating vascular quiescence factor. in Circulation research 2008
Data suggest ALK1 (show ACVRL1 Antibodies) and ACVR2A (show ACVR2A Antibodies)/ACVR2B (show ACVR2B Antibodies), acting as BMP9 co-receptors, rearrange pro-domains of BMP9--pro-domain dimer complex leading to displacement of pro-domains after receptor binding, release of mature non-dimer BPM9, and activation of signaling.
DLL4 (show DLL4 Antibodies)/Notch1 (show NOTCH1 Antibodies) and BMP9 interdependent signaling induces endothelial cell quiescence via P27KIP1 (show CDKN1B Antibodies)/thrombospondin pathway.
BMP9 Crosstalk with the Hippo Pathway Regulates Endothelial Cell Matricellular and Chemokine (show CCL1 Antibodies) Responses
BMP-9 induces vascular smooth muscle cell osteogenic differentiation and calcification via ALK1 (show ACVRL1 Antibodies), Smad (show SMAD1 Antibodies) and ALP (show ALP Antibodies) dependent mechanisms.
This review summarizes the indirect connection between BMP9 and liver fibrosis, with a focus on the BMP9 signaling pathway members ALK1 (show ACVRL1 Antibodies), endoglin (show ENG Antibodies), Id1 (show ID1 Antibodies), hepcidin (show HAMP Antibodies) and Snail (show SNAI1 Antibodies). [review]
Data show that bone morphogenetic protein 9 (BMP9) can inhibit the migration and invasion of MDA-MB-231 breast cancer cells and promote osteogenesis and proliferation of HS-5 bone marrow-derived mesenchymal stem cells in the co-culture system.
structural analysis of the bone morphogenetic protein 9 procomplex
These findings suggest that BMP9 can inhibit the proliferation and metastasis of SK-BR-3 cells via inactivating ERK1/2 (show MAPK1/3 Antibodies) and PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling pathways
BMP9 is regulated by redox-dependent proteolysis
in primary, non-malignant cells BMP-9 stabilizes the epithelial phenotype and inhibits proliferation, in hepatocellular carcinoma cells it induces cell growth and the acquisition of a migratory phenotype.
Hh signaling is involved and plays a regulatory role in the osteogenic differentiation of MSCs induced by BMP9.
data indicate that BMP9 and BMP13 (show GDF6 Antibodies) (BMP9 might be more effective) promoted the differentiation of C3H10T1/2 cells into cardiomyocyte-like cells
BMP9/ALK1 (show ACVRL1 Antibodies) augmented vasculogenesis and angiogenesis, and thereby enhanced neovascularization. Thus, we suggest that BMP9/ALK1 (show ACVRL1 Antibodies) may improve the efficacy of EPC (show TCF21 Antibodies)-based therapies for treating ischemic diseases.
result was supported by the identification of the regulation by BMP9 and BMP10 (show BMP10 Antibodies) of several genes known to be involved in this process
BMP-9 induces vascular smooth muscle cell osteogenic differentiation and calcification via ALK1 (show ACVRL1 Antibodies), Smad (show SMAD1 Antibodies) and ALP (show CCL21A Antibodies) dependent mechanisms.
These findings suggest that PTEN (show PTEN Antibodies) plays an important role in regulating BMP9 induced osteogenic differentiation in MPCs, which may be mediated by PTEN (show PTEN Antibodies)/PI3K/Akt (show AKT1 Antibodies) signaling to modulate the expression of COX-2 (show COX2 Antibodies).
BMP9 may be explored as a novel and efficacious factor for odontogenic regeneration.
IGF2 increased the protein levels of hippocampal BMP9, NGF (show NGFB Antibodies), BDNF (show BDNF Antibodies), NT3 (show NTF3 Antibodies) and IGF1 (show IGF1 Antibodies) and of doublecortin (show DCX Antibodies), a marker of neurogenesis.
Data indicate that extracellular signal-regulated kinase 5 (ERK5 (show MAPK7 Antibodies)) and c-Jun N-terminal kinase (JNK) are important in the differentiation of C3H10T1/2 cells into cardiomyocyte-like cells induced by bone morphogenetic protein 9 (BMP9) transfection.
results strongly suggest that Creld2 (show CRELD2 Antibodies) may be directly regulated by BMP9 and ER stress response may play an important role in regulating osteogenic differentiation
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein plays a role in the adult liver and in differentiation of cholinergic central nervous system neurons.
bone morphogenetic protein 9
, growth/differentiation factor 2