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The protein encoded by GDF3 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. Additionally we are shipping GDF3 Antibodies (85) and GDF3 Kits (39) and many more products for this protein.
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Human GDF3 Protein expressed in Escherichia coli (E. coli) - ABIN2667419
Chacón-Camacho, Camarillo-Blancarte, Pelaez-González, Mendiola, Zenteno: Klippel-Feil syndrome associated with situs inversus: description of a new case and exclusion of GDF1, GDF3 and GDF6 as causal genes. in European journal of medical genetics 2012
Show all 6 references for ABIN2667419
The results expand the spectrum of mutations associated with CHDs and first suggest the potentially disease-related GDF3 gene variant in the pathogenesis of CHDs.
first evidence that NANOG (show NANOG Proteins) is a transcriptional activator of the expression of the oncogenic growth factor GDF3 in embryonic carcinoma cells
GDF3 expression level was significantly down-regulated in breast cancer tissues compared to the surrounding nontumorous tissues.
the conditioned medium from CHO-GDF3 could reduce PC12 cell growth and induce cell differentiation
Growth differentiation factor 3 is induced by bone morphogenetic protein 6 (BMP-6 (show BMP6 Proteins)) and BMP-7 (show BMP7 Proteins) and increases luteinizing hormone receptor (show LHCGR Proteins) messenger RNA expression in human granulosa cells.
Mutation of GDF3 causes ocular and skeletal anomalies.
Present data suggested that GDF3 might play important roles in the central nervous system (CNS), especially in cerebral cortex, hippocampus and cerebellum, and it shed new light on further research of GDF3 in the central nervous system.
GDF3 regulates both of the two major characteristics of embryonic stem cells: the ability to maintain the undifferentiated state and the ability to differentiate into the full spectrum of cell types.
GDF3 regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the ALK7 (show ACVR1C Proteins) receptor
GDF3 is either a bi-functional TGF-beta ligand, or, more likely, that it is a BMP inhibitor that can artificially activate Nodal signaling under non-physiological conditions.
GDF3 has the ability to induce progression of CD24 (show CD24 Proteins)-inducible melanoma in mice.
Mice transduced with GDF-3 displayed profound weight gain when fed with high fat diet. The phenotypes included greatly expanded adipose tissue mass, increased body adiposity, highly hypertrophic adipocytes, hepatic steatosis, and elevated plasma leptin (show LEP Proteins).
Gdf3 is expressed in the inner cell mass and epiblast, and null mutants frequently exhibit abnormal formation or positioning of the anterior visceral endoderm in pre-gastrulation development
Results suggest that GDF1 (show GDF1 Proteins) and GDF3 together represent the functional mammalian homologs of Vg1.
GDF3 deficiency selectively affects white adipose through its influence on basal metabolic rates.
Xnr1 (show NODAL Proteins) and derriere are coexpressed in the posterior paraxial mesoderm at neurula stage, and with Coco (show DAND5 Proteins) define a posttranscriptionally regulated signaling center in the chain leading to an increased TGF-beta (show TGFB1 Proteins) signal on the left side of the embryo.
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues.
, growth/differentiation factor 3
, VG-1-related protein 2
, growth factor CVg1
, derriA re
, derriere (posterior determination, TGFb family member)
, derriere (tgf-beta family member)
, derriere protein