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anti-Growth Differentiation Factor 5 (GDF5) Antibodies

The protein encoded by GDF5 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. Additionally we are shipping GDF5 Kits (51) and GDF5 Proteins (42) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GDF5 8200 P43026
GDF5 14563 P43027
GDF5 252835  
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Top anti-GDF5 Antibodies at antibodies-online.com

Showing 10 out of 119 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-GDF5 N-term Pab (ABIN388820) is used in Western blot to detect GDF5 in A549 cell lysate. Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with GDF5 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue reacted with BMP14 / GDF5 Antibody (C-term) followed by peroxidase conjugation of the secondary antibody and DAB staining. Western blot analysis of BMP14 / GDF5 Antibody (C-term) in MDA-MB435 cell line lysates (35ug/lane). This demonstrates the GDF5 antibody detected the GDF5 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB GDF5 Antibody (C-term)  western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the GDF5 antibody detected the GDF5 protein (arrow). GDF5 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of GDF5 Antibody (C-term) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-GDF5 AntibodyTitration: 1.0 µg/mL  Positive Control: Placenta 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IHC (p) 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IHC (p), ELISA Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC (p), WB Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC, ELISA 0.05 mg Log in to see 2 to 3 Days
$481.25
Details
Human Rabbit APC IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details

GDF5 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-GDF5 Antibodies

  1. Human Polyclonal GDF5 Primary Antibody for EIA, WB - ABIN357461 : Kusafuka, Luyten, De Bondt, Hiraki, Shukunami, Kayano, Takemura: Immunohistochemical evaluation of cartilage-derived morphogenic protein-1 and -2 in normal human salivary glands and pleomorphic adenomas. in Virchows Archiv : an international journal of pathology 2003 (PubMed)
    Show all 5 references for ABIN357461

  2. Human Polyclonal GDF5 Primary Antibody for IHC (p), WB - ABIN388820 : Liu, Lin, Sytwu, Chang: GDF-5 is suppressed by IL-1beta and enhances TGF-beta3-mediated chondrogenic differentiation in human rheumatoid fibroblast-like synoviocytes. in Experimental and molecular pathology 2010 (PubMed)
    Show all 4 references for ABIN388820

  3. Human Polyclonal GDF5 Primary Antibody for EIA, IHC (p) - ABIN950667 : Posthumus, Collins, Cook, Handley, Ribbans, Smith, Schwellnus, Raleigh: Components of the transforming growth factor-beta family and the pathogenesis of human Achilles tendon pathology--a genetic association study. in Rheumatology (Oxford, England) 2010 (PubMed)
    Show all 2 references for ABIN950667

More Antibodies against GDF5 Interaction Partners

Xenopus laevis Growth Differentiation Factor 5 (GDF5) interaction partners

  1. Changes in the expression of downstream regulators of skeletal differentiation, like barx1 (show BARX1 Antibodies) and gdf5, is one mechanism by which head skeletal element number and articulation are altered during evolution.

  2. Results suggest that CDMP1/GDF5 requires cleavage by two distinct proteolytic enzymes.

Human Growth Differentiation Factor 5 (GDF5) interaction partners

  1. The data suggest that Ad-GDF-5 gene (show GPD1 Antibodies) therapy is a potential treatment for IDD (show COL9A3 Antibodies), which restores the functions of degenerative intervertebral disc through enhancing the ECM (show MMRN1 Antibodies) production of human NP cells.

  2. An association of SNP in GDF5 with temporomandibular joint osteoarthritis in female Han Chinese.

  3. results demonstrate that SNP rs143383 of GDF5 is a compelling risk factor for both knee and hand osteoarthritis (OA) and provide further support for GDF5 in the etiology of OA [meta-analysis]

  4. Two novel homozygous missense mutations in the GDF5 gene cause brachydactyly type C.

  5. our results showed that GDF-5 and BMPRII (show BMPR2 Antibodies) expressed both in normal and degenerated intervertebral disc tissues, and GDF-5 might have an inhibition effect on degenerated lumbar intervertebral discs

  6. This meta-analysis finds that the C allele and CC genotype of the GDF5 gene are protective for knee osteoarthritis susceptibility.

  7. Our results revealed that the GDF5 SNP was associated with susceptibility to the meniscus injury and postoperative function recovery in Chinese male soldiers.

  8. missense mutations p.T201P and p.L263P interfere with the protein structure and thereby reduce the amount of fully processed, biologically active GDF5, finally causing the clinical loss of function phenotype.

  9. Growth differentiation factor 5 and canonical Wnt (show WNT2 Antibodies) signaling may contribute to molecular mechanisms of osteoarthritis.

  10. These results suggest that obesity leads to upregulation of GDF5 expression responsible for the promotion of brown adipogenesis through a mechanism relevant to activation of the NF-kappaB (show NFKB1 Antibodies) pathway.

Mouse (Murine) Growth Differentiation Factor 5 (GDF5) interaction partners

  1. Growth differentiation factor 5 is a novel target-derived factor that promotes sympathetic axon growth and branching and makes a distinctive regional contribution to the establishment of sympathetic innervation.

  2. Dach2 (show DACH2 Antibodies) and Hdac9 (show HDAC9 Antibodies) mediate the effects of muscle activity on muscle reinnervation; Myog (show MYOG Antibodies) and Gdf5 appear to stimulate muscle reinnervation through parallel pathways

  3. Gdf-5 induced the expression of the alpha5 sub-unit, while Bmp-7 (show BMP7 Antibodies) induced the expression of the alphaV sub-unit.

  4. Clonal expansion of Gdf5 progenitors contributes to linear growth of the enthesis.

  5. GDF5 might play a critical role in 3T3-L1 preadipocyte differentiation

  6. These results suggest that PI3K/Akt (show AKT1 Antibodies) signals play a role in the GDF5-mediated brown adipogenesis through a mechanism related to activation of the Smad (show SMAD1 Antibodies) pathway.

  7. These results suggest that brown adipogenesis and energy homeostasis are both positively regulated by the GDF5/BMPR (show BMPR1A Antibodies)/Smad (show SMAD1 Antibodies)/PGC-1alpha (show PPARGC1A Antibodies) signaling pathway in adipose tissues.

  8. apical and basal dendritic arbours of pyramidal cells throughout the hippocampus were stunted in both homozygous and heterozygous Gdf5 null mutants, indicating that dendrite size and complexity are sensitive to the level of endogenous GDF5 synthesis.

  9. This work implicates SOX11 (show SOX11 Antibodies) as a potential regulator of GDF5 expression in joint maintenance and suggests a possible role in the pathogenesis of osteoarthritis

  10. A novel molecular mechanism of a GDF5 mutation affecting chondrogenesis and osteogenesis, is reported.

Cow (Bovine) Growth Differentiation Factor 5 (GDF5) interaction partners

  1. These results suggest that the SNP of the GDF5 gene could be a very useful genetic marker for body measurement traits in the bovine reproduction and breeding.

GDF5 Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type\; brachydactyly, type C\; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development.

Gene names and symbols associated with GDF5

  • growth differentiation factor 5 (gdf5) antibody
  • growth differentiation factor 5 (GDF5) antibody
  • growth differentiation factor 5 (Gdf5) antibody
  • BDA1C antibody
  • BMP14 antibody
  • bp antibody
  • brp antibody
  • Cdmp-1 antibody
  • Cdmp1 antibody
  • gdf antibody
  • gdf-5 antibody
  • GDF5 antibody
  • LAP4 antibody
  • OS5 antibody
  • SYM1B antibody
  • SYNS2 antibody

Protein level used designations for GDF5

growth factor GDF5 , growth differentiation factor 5 , growth/differentiation factor 5-like , CDMP-1 , GDF-5 , cartilage-derived morphogenetic protein-1 , growth/differentiation factor 5 , radotermin , brachypodism , cartilage-derived morphogenetic protein 1 , growth differentiation factor 5 preproprotein , growth differentiation factor 5 (cartilage-derived morphogenetic protein-1)

GENE ID SPECIES
446295 Xenopus laevis
100137480 Papio anubis
100393400 Callithrix jacchus
8200 Homo sapiens
14563 Mus musculus
252835 Rattus norvegicus
100328897 Oryctolagus cuniculus
100723808 Cavia porcellus
100520988 Sus scrofa
485850 Canis lupus familiaris
539559 Bos taurus
374249 Gallus gallus
101116499 Ovis aries
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