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Growth Differentiation Factor 5 Proteins (GDF5)

The protein encoded by GDF5 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. Additionally we are shipping GDF5 Antibodies (120) and GDF5 Kits (40) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GDF5 8200 P43026
GDF5 14563 P43027
Rat GDF5 GDF5 252835  
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Top GDF5 Proteins at antibodies-online.com

Showing 10 out of 38 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 2 to 3 Days
$225.75
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 4 to 6 Days
$396.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$739.20
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 2 to 3 Days
$225.75
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 7 to 9 Days
$328.21
Details
HOST_Escherichia coli (E. coli) Mouse His tag   100 μg Log in to see 11 to 13 Days
$616.00
Details

GDF5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Mouse (Murine)

Top referenced GDF5 Proteins

  1. Human GDF5 Protein expressed in Escherichia coli (E. coli) - ABIN666773 : Feng, Wan, Balian, Laurencin, Li: Adenovirus-mediated expression of growth and differentiation factor-5 promotes chondrogenesis of adipose stem cells. in Growth factors (Chur, Switzerland) 2008 (PubMed)
    Show all 2 references for ABIN666773

  2. Human GDF5 Protein expressed in Escherichia coli (E. coli) - ABIN413315 : Saiga, Furumatsu, Yoshida, Masuda, Takihira, Abe, Ozaki: Combined use of bFGF and GDF-5 enhances the healing of medial collateral ligament injury. in Biochemical and biophysical research communications 2010 (PubMed)

More Proteins for Growth Differentiation Factor 5 (GDF5) Interaction Partners

Xenopus laevis Growth Differentiation Factor 5 (GDF5) interaction partners

  1. Changes in the expression of downstream regulators of skeletal differentiation, like barx1 (show BARX1 Proteins) and gdf5, is one mechanism by which head skeletal element number and articulation are altered during evolution.

  2. Results suggest that CDMP1/GDF5 requires cleavage by two distinct proteolytic enzymes.

Human Growth Differentiation Factor 5 (GDF5) interaction partners

  1. The prevention of IL-1Beta (show IL1B Proteins)-induced nucleus pulposus extracellular matrix degeneration by miR-7 (show LILRB1 Proteins) silencing was attenuated by GDF5 siRNA.

  2. Mutations in three genes (GDF5, NPR2 (show NPRL2 Proteins), BMPR1B (show BMPR1B Proteins)) have been reported to cause different forms of acromesomelic dysplasia

  3. we demonstrate that the transforming growth factor-beta1 and the growth differentiation factor 5 synergistically drive the nucleopulpogenic differentiation process. The commitment of the hASCs was robust and highly specific as attested by the expression of NP-related genes characteristic of young healthy human NP cells

  4. The data suggest that Ad-GDF-5 gene (show GPD1 Proteins) therapy is a potential treatment for IDD (show COL9A3 Proteins), which restores the functions of degenerative intervertebral disc through enhancing the ECM (show MMRN1 Proteins) production of human NP cells.

  5. An association of SNP in GDF5 with temporomandibular joint osteoarthritis in female Han Chinese.

  6. results demonstrate that SNP rs143383 of GDF5 is a compelling risk factor for both knee and hand osteoarthritis (OA) and provide further support for GDF5 in the etiology of OA [meta-analysis]

  7. Two novel homozygous missense mutations in the GDF5 gene cause brachydactyly type C.

  8. our results showed that GDF-5 and BMPRII (show BMPR2 Proteins) expressed both in normal and degenerated intervertebral disc tissues, and GDF-5 might have an inhibition effect on degenerated lumbar intervertebral discs

  9. This meta-analysis finds that the C allele and CC genotype of the GDF5 gene are protective for knee osteoarthritis susceptibility.

  10. Our results revealed that the GDF5 SNP was associated with susceptibility to the meniscus injury and postoperative function recovery in Chinese male soldiers.

Mouse (Murine) Growth Differentiation Factor 5 (GDF5) interaction partners

  1. Mutant GDF5 enhances ameloblast differentiation via accelerated BMP2 (show BMP2 Proteins)-induced Smad1 (show SMAD1 Proteins)-Smad5 (show SMAD5 Proteins)-Smad8 (show SMAD9 Proteins) phosphorylation.

  2. Combined, these data suggest a possible pathway linking GDF5, ERG (show ERG Proteins) and downstream factors in the processes of chondrocyte differentiation during articular joint formation.

  3. Growth differentiation factor 5 is a novel target-derived factor that promotes sympathetic axon growth and branching and makes a distinctive regional contribution to the establishment of sympathetic innervation.

  4. Dach2 (show DACH2 Proteins) and Hdac9 (show HDAC9 Proteins) mediate the effects of muscle activity on muscle reinnervation; Myog (show MYOG Proteins) and Gdf5 appear to stimulate muscle reinnervation through parallel pathways

  5. Gdf-5 induced the expression of the alpha5 sub-unit, while Bmp-7 (show BMP7 Proteins) induced the expression of the alphaV sub-unit.

  6. Clonal expansion of Gdf5 progenitors contributes to linear growth of the enthesis.

  7. GDF5 might play a critical role in 3T3-L1 preadipocyte differentiation

  8. These results suggest that PI3K/Akt (show AKT1 Proteins) signals play a role in the GDF5-mediated brown adipogenesis through a mechanism related to activation of the Smad (show SMAD1 Proteins) pathway.

  9. These results suggest that brown adipogenesis and energy homeostasis are both positively regulated by the GDF5/BMPR/Smad/PGC-1alpha signaling pathway in adipose tissues.

  10. apical and basal dendritic arbours of pyramidal cells throughout the hippocampus were stunted in both homozygous and heterozygous Gdf5 null mutants, indicating that dendrite size and complexity are sensitive to the level of endogenous GDF5 synthesis.

Cow (Bovine) Growth Differentiation Factor 5 (GDF5) interaction partners

  1. These results suggest that the SNP of the GDF5 gene could be a very useful genetic marker for body measurement traits in the bovine reproduction and breeding.

GDF5 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type\; brachydactyly, type C\; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development.

Gene names and symbols associated with GDF5

  • growth differentiation factor 5 (gdf5)
  • growth differentiation factor 5 (GDF5)
  • growth differentiation factor 5 (Gdf5)
  • BDA1C protein
  • BMP14 protein
  • bp protein
  • brp protein
  • Cdmp-1 protein
  • Cdmp1 protein
  • gdf protein
  • gdf-5 protein
  • GDF5 protein
  • LAP4 protein
  • OS5 protein
  • SYM1B protein
  • SYNS2 protein

Protein level used designations for GDF5

growth factor GDF5 , growth differentiation factor 5 , growth/differentiation factor 5-like , CDMP-1 , GDF-5 , cartilage-derived morphogenetic protein-1 , growth/differentiation factor 5 , radotermin , brachypodism , cartilage-derived morphogenetic protein 1 , growth differentiation factor 5 preproprotein , growth differentiation factor 5 (cartilage-derived morphogenetic protein-1)

GENE ID SPECIES
446295 Xenopus laevis
100137480 Papio anubis
100393400 Callithrix jacchus
8200 Homo sapiens
14563 Mus musculus
252835 Rattus norvegicus
100328897 Oryctolagus cuniculus
100723808 Cavia porcellus
100520988 Sus scrofa
485850 Canis lupus familiaris
539559 Bos taurus
374249 Gallus gallus
101116499 Ovis aries
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