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The protein encoded by GDF5 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. Additionally we are shipping GDF5 Antibodies (114) and GDF5 Kits (51) and many more products for this protein.
Showing 10 out of 42 products:
Human GDF5 Protein expressed in Escherichia coli (E. coli) - ABIN666773
Feng, Wan, Balian, Laurencin, Li: Adenovirus-mediated expression of growth and differentiation factor-5 promotes chondrogenesis of adipose stem cells. in Growth factors (Chur, Switzerland) 2008
Show all 2 references for ABIN666773
Human GDF5 Protein expressed in Escherichia coli (E. coli) - ABIN413315
Saiga, Furumatsu, Yoshida, Masuda, Takihira, Abe, Ozaki: Combined use of bFGF and GDF-5 enhances the healing of medial collateral ligament injury. in Biochemical and biophysical research communications 2010
Changes in the expression of downstream regulators of skeletal differentiation, like barx1 (show BARX1 Proteins) and gdf5, is one mechanism by which head skeletal element number and articulation are altered during evolution.
Results suggest that CDMP1/GDF5 requires cleavage by two distinct proteolytic enzymes.
The data suggest that Ad-GDF-5 gene (show GPD1 Proteins) therapy is a potential treatment for IDD (show COL9A3 Proteins), which restores the functions of degenerative intervertebral disc through enhancing the ECM (show MMRN1 Proteins) production of human NP cells.
An association of SNP in GDF5 with temporomandibular joint osteoarthritis in female Han Chinese.
results demonstrate that SNP rs143383 of GDF5 is a compelling risk factor for both knee and hand osteoarthritis (OA) and provide further support for GDF5 in the etiology of OA [meta-analysis]
Two novel homozygous missense mutations in the GDF5 gene cause brachydactyly type C.
our results showed that GDF-5 and BMPRII (show BMPR2 Proteins) expressed both in normal and degenerated intervertebral disc tissues, and GDF-5 might have an inhibition effect on degenerated lumbar intervertebral discs
This meta-analysis finds that the C allele and CC genotype of the GDF5 gene are protective for knee osteoarthritis susceptibility.
Our results revealed that the GDF5 SNP was associated with susceptibility to the meniscus injury and postoperative function recovery in Chinese male soldiers.
missense mutations p.T201P and p.L263P interfere with the protein structure and thereby reduce the amount of fully processed, biologically active GDF5, finally causing the clinical loss of function phenotype.
Growth differentiation factor 5 and canonical Wnt (show WNT2 Proteins) signaling may contribute to molecular mechanisms of osteoarthritis.
These results suggest that obesity leads to upregulation of GDF5 expression responsible for the promotion of brown adipogenesis through a mechanism relevant to activation of the NF-kappaB (show NFKB1 Proteins) pathway.
Dach2 (show DACH2 Proteins) and Hdac9 (show HDAC9 Proteins) mediate the effects of muscle activity on muscle reinnervation; Myog (show MYOG Proteins) and Gdf5 appear to stimulate muscle reinnervation through parallel pathways
Gdf-5 induced the expression of the alpha5 sub-unit, while Bmp-7 (show BMP7 Proteins) induced the expression of the alphaV sub-unit.
Clonal expansion of Gdf5 progenitors contributes to linear growth of the enthesis.
GDF5 might play a critical role in 3T3-L1 preadipocyte differentiation
These results suggest that PI3K/Akt (show AKT1 Proteins) signals play a role in the GDF5-mediated brown adipogenesis through a mechanism related to activation of the Smad (show SMAD1 Proteins) pathway.
These results suggest that brown adipogenesis and energy homeostasis are both positively regulated by the GDF5/BMPR/Smad/PGC-1alpha signaling pathway in adipose tissues.
apical and basal dendritic arbours of pyramidal cells throughout the hippocampus were stunted in both homozygous and heterozygous Gdf5 null mutants, indicating that dendrite size and complexity are sensitive to the level of endogenous GDF5 synthesis.
This work implicates SOX11 (show SOX11 Proteins) as a potential regulator of GDF5 expression in joint maintenance and suggests a possible role in the pathogenesis of osteoarthritis
A novel molecular mechanism of a GDF5 mutation affecting chondrogenesis and osteogenesis, is reported.
Data show that revealed notochord cells in Gdf-5-null mice correctly form nuclei pulposi.
These results suggest that the SNP of the GDF5 gene could be a very useful genetic marker for body measurement traits in the bovine reproduction and breeding.
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type\; brachydactyly, type C\; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development.
growth factor GDF5
, growth differentiation factor 5
, growth/differentiation factor 5-like
, cartilage-derived morphogenetic protein-1
, growth/differentiation factor 5
, cartilage-derived morphogenetic protein 1
, growth differentiation factor 5 preproprotein
, growth differentiation factor 5 (cartilage-derived morphogenetic protein-1)