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The protein encoded by GDF5 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. Additionally we are shipping GDF5 Antibodies (122) and GDF5 Kits (46) and many more products for this protein.
Showing 10 out of 41 products:
Human GDF5 Protein expressed in Escherichia coli (E. coli) - ABIN666773
Feng, Wan, Balian, Laurencin, Li: Adenovirus-mediated expression of growth and differentiation factor-5 promotes chondrogenesis of adipose stem cells. in Growth factors (Chur, Switzerland) 2008
Show all 2 references for ABIN666773
Human GDF5 Protein expressed in Escherichia coli (E. coli) - ABIN413315
Saiga, Furumatsu, Yoshida, Masuda, Takihira, Abe, Ozaki: Combined use of bFGF and GDF-5 enhances the healing of medial collateral ligament injury. in Biochemical and biophysical research communications 2010
Changes in the expression of downstream regulators of skeletal differentiation, like barx1 (show BARX1 Proteins) and gdf5, is one mechanism by which head skeletal element number and articulation are altered during evolution.
Results suggest that CDMP1/GDF5 requires cleavage by two distinct proteolytic enzymes.
he large array of modular enhancers for Gdf5 provide a new foundation for studying the spatial specificity of joint patterning in vertebrates, as well as new candidates for regulatory regions that may also influence osteoarthritis risk in human population
The purpose of this study is to investigate the immunohistochemical expression of cytokeratin 18 (CK18 (show KRT18 Proteins)) and the reactivity to GDF5 (CDMP-1), called the morphogenetic protein-1, cartilage-derived, in lingual squamous cell carcinoma.
homozygous sequence variants in the GDF5 gene underlie acromesomelic dysplasia type-grebe in consanguineous families
The prevention of IL-1Beta (show IL1B Proteins)-induced nucleus pulposus extracellular matrix degeneration by miR-7 (show LILRB1 Proteins) silencing was attenuated by GDF5 siRNA.
Mutations in three genes (GDF5, NPR2 (show NPRL2 Proteins), BMPR1B (show BMPR1B Proteins)) have been reported to cause different forms of acromesomelic dysplasia
we demonstrate that the transforming growth factor-beta1 and the growth differentiation factor 5 synergistically drive the nucleopulpogenic differentiation process. The commitment of the hASCs was robust and highly specific as attested by the expression of NP-related genes characteristic of young healthy human NP cells
The data suggest that Ad-GDF-5 gene (show GPD1 Proteins) therapy is a potential treatment for IDD (show COL9A3 Proteins), which restores the functions of degenerative intervertebral disc through enhancing the ECM (show MMRN1 Proteins) production of human NP cells.
An association of SNP in GDF5 with temporomandibular joint osteoarthritis in female Han Chinese.
results demonstrate that SNP rs143383 of GDF5 is a compelling risk factor for both knee and hand osteoarthritis (OA) and provide further support for GDF5 in the etiology of OA [meta-analysis]
Two novel homozygous missense mutations in the GDF5 gene cause brachydactyly type C.
Mutant GDF5 enhances ameloblast differentiation via accelerated BMP2 (show BMP2 Proteins)-induced Smad1 (show SMAD1 Proteins)-Smad5 (show SMAD5 Proteins)-Smad8 (show SMAD9 Proteins) phosphorylation.
Combined, these data suggest a possible pathway linking GDF5, ERG (show ERG Proteins) and downstream factors in the processes of chondrocyte differentiation during articular joint formation.
Growth differentiation factor 5 is a novel target-derived factor that promotes sympathetic axon growth and branching and makes a distinctive regional contribution to the establishment of sympathetic innervation.
Dach2 (show DACH2 Proteins) and Hdac9 (show HDAC9 Proteins) mediate the effects of muscle activity on muscle reinnervation; Myog (show MYOG Proteins) and Gdf5 appear to stimulate muscle reinnervation through parallel pathways
Gdf-5 induced the expression of the alpha5 sub-unit, while Bmp-7 (show BMP7 Proteins) induced the expression of the alphaV sub-unit.
Clonal expansion of Gdf5 progenitors contributes to linear growth of the enthesis.
GDF5 might play a critical role in 3T3-L1 preadipocyte differentiation
These results suggest that PI3K/Akt (show AKT1 Proteins) signals play a role in the GDF5-mediated brown adipogenesis through a mechanism related to activation of the Smad (show SMAD1 Proteins) pathway.
These results suggest that brown adipogenesis and energy homeostasis are both positively regulated by the GDF5/BMPR/Smad/PGC-1alpha signaling pathway in adipose tissues.
These results suggest that the SNP of the GDF5 gene could be a very useful genetic marker for body measurement traits in the bovine reproduction and breeding.
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type\; brachydactyly, type C\; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development.
growth factor GDF5
, growth differentiation factor 5
, growth/differentiation factor 5-like
, cartilage-derived morphogenetic protein-1
, growth/differentiation factor 5
, cartilage-derived morphogenetic protein 1
, growth differentiation factor 5 preproprotein
, growth differentiation factor 5 (cartilage-derived morphogenetic protein-1)