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anti-Growth Factor Receptor-Bound Protein 10 (GRB10) Antibodies

The product of GRB10 belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. Additionally we are shipping GRB10 Kits (41) and GRB10 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GRB10 14783 Q60760
GRB10 498416  
GRB10 2887 Q13322
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Top anti-GRB10 Antibodies at antibodies-online.com

Showing 10 out of 78 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IF, ELISA, WB Western blot analysis of extracts from NIH-3T3 cells treated with Insu... Immunofluorescence analysis of HepG2 cells, using GRB10 (Phospho-Tyr67... 100 μg Log in to see 2 to 3 Days
$275.00
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from NIH-3T3 cells, treated with Ins... Immunohistochemistry analysis of paraffin-embedded human brain tissue,... 100 μg Log in to see 2 to 3 Days
$275.00
Details
Human Rabbit Un-conjugated EIA, IF, WB Immunofluorescence of GRB10 in rat brain cells with GRB10 Antibody   a... Western blot analysis of GRB10 in SK-N-SH cell lysate with GRB10 Antib... 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated WB GRB10 Antibody (N-term) (ABIN1881389) western blot analysis in A549,MD... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-GRB10 antibody,  IHC(P) IHC(P): Human Mammary Cancer Tissue Anti-GRB10 antibody,  Western blotting Lane 1: Rat Liver Tissue Lysate... 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Rabbit Un-conjugated IF, ELISA, IHC (p), WB 100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Rabbit Un-conjugated IC, IF, WB Immunofluorescent analysis of GRB10 (pY67) staining in PC12 cells. For... Western blot analysis of GRB10 (pY67) expression in HEK293T insulin-tr... 200 μL Log in to see 9 Days
$575.00
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Immunohistochemistry analyzes of GRB10 antibody in paraffin-embedded h... Western blot analysis of GRB10 antibody in extracts from NIH/3T3 cells... 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 14 Days
$527.15
Details
Human Rabbit Un-conjugated IF, ELISA, WB 100 μg Log in to see 11 to 16 Days
$412.86
Details

GRB10 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine) , , , ,

Rat (Rattus) , , , ,

Human , , , ,
, ,

Top referenced anti-GRB10 Antibodies

  1. Human Polyclonal GRB10 Primary Antibody for EIA, IF - ABIN1450124 : Morrione: Grb10 proteins in insulin-like growth factor and insulin receptor signaling (review). in International journal of molecular medicine 2000 (PubMed)
    Show all 6 references for ABIN1450124

  2. Human Polyclonal GRB10 Primary Antibody for WB - ABIN1881389 : ONeill, Rose, Pillay, Hotta, Olefsky, Gustafson: Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling. in The Journal of biological chemistry 1996 (PubMed)
    Show all 5 references for ABIN1881389

  3. Human Polyclonal GRB10 Primary Antibody for IF, IHC - ABIN1532670 : Angrist, Bolk, Bentley, Nallasamy, Halushka, Chakravarti: Genomic structure of the gene for the SH2 and pleckstrin homology domain-containing protein GRB10 and evaluation of its role in Hirschsprung disease. in Oncogene 1999 (PubMed)

More Antibodies against GRB10 Interaction Partners

Mouse (Murine) Growth Factor Receptor-Bound Protein 10 (GRB10) interaction partners

  1. In tumors, Grb10 loss independently promotes Ras pathway hyperactivation, which promotes hyperproliferation, an early feature of tumor development.

  2. This study identified Grb10 as a critical regulator of lipid metabolism, the programming of the browning phenotype, and thermogenesis in adipose tissues.

  3. Negative regulation of Grb10 Interacting GIGYF2 (show GIGYF2 Antibodies) protein on IGF-1 (show IGF1 Antibodies) receptor signaling pathway caused diabetic mice cognitive impairment.

  4. Grb10 is involved in BCR-ABL (show ABL1 Antibodies)-positive leukemia in mice.

  5. Grb10 is a key genetic component of developmental programming.

  6. Glucose uptake was higher in Grb10(-/-) primary myotubes in the basal state and was associated with enhanced insulin (show INS Antibodies) signaling and an increase in GLUT4 (show SLC2A4 Antibodies) translocation to the plasma membrane.

  7. Grb10 expression in mouse embryo is regulated by Lmx1a (show LMX1A Antibodies) transcription factor.

  8. Results suggest consecutive passaging may affect epigenetic modifications of Grb10 in adult fibroblast cells.

  9. Study has identified Grb10 as an important regulator of beta-cell proliferation and demonstrated that reducing the expression level of Grb10 could provide a novel means to increase beta-cell mass and reduce beta-cell apoptosis.

  10. Grb10-ablated muscle from adult mice shows coordinate gene changes that oppose those of muscle wasting pathologies, highlighting Grb10 as a potential therapeutic target for these conditions

Human Growth Factor Receptor-Bound Protein 10 (GRB10) interaction partners

  1. Risk alleles for 6 loci increased glucose levels from birth to 5 years of age (ADCY5 (show ADCY5 Antibodies), ADRA2A (show ADRA2A Antibodies), CDKAL1 (show CDKAL1 Antibodies), CDKN2A (show CDKN2A Antibodies)/B, GRB10, and TCF7L2 (show TCF7L2 Antibodies)

  2. This study demonstrated that the most significant SNP (rs11770199; p = 0.0003) in single-site analysis was located on chromosome 7 in the GRB10 gene.

  3. Association of the intronic polymorphism rs12540874 A>G of the GRB10 gene with high birth weight.

  4. Tissue-specific methylation and possibly imprinting of GRB10 can influence glucose metabolism.

  5. Grb10 binds to both normal and oncogenic FLT3 (show FLT3 Antibodies) and induces PI3K (show PIK3CA Antibodies)-Akt (show AKT1 Antibodies) and STAT5 (show STAT5A Antibodies) signaling pathways resulting in an enhanced proliferation, survival and colony formation of hematopoietic cells.

  6. Studies indicate that insulin receptor (IR (show INSR Antibodies)) and IGF Type 1 Receptor (IGFR) have been identified as important partners of Grb10/14 and SH2B1 (show SH2B1 Antibodies)/B2 adaptors.

  7. H19 (show NCKAP1 Antibodies) and GRB10 methylation was normal in Albright's hereditary osteodystrophy patients.

  8. discovery of Grb10 as an mTORC1 substrate

  9. Grb10 interacts with Bim (show BCL2L11 Antibodies) L and inhibits its proapoptotic activity in a phosphorylation-dependant manner.

  10. GRB10 gene is expressed from the paternal allele in the brain, but from the maternal allele in the placental trophoblasts.

GRB10 Antigen Profile

Protein Summary

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with GRB10

  • growth factor receptor-bound protein 10 (GRB10) antibody
  • growth factor receptor-bound protein 10a (grb10a) antibody
  • growth factor receptor-bound protein 10 (grb10) antibody
  • growth factor receptor-bound protein 10 (LOC100224775) antibody
  • growth factor receptor bound protein 10 (Grb10) antibody
  • growth factor receptor-bound protein 10 (Grb10) antibody
  • growth factor receptor-bound protein 10-like (LOC100355737) antibody
  • 5730571D09Rik antibody
  • AI325020 antibody
  • Grb-10 antibody
  • GRB-IR antibody
  • GRB10 antibody
  • IRBP antibody
  • LOC100224775 antibody
  • MEG1 antibody
  • mKIAA0207 antibody
  • RGD1566234 antibody
  • RSS antibody
  • zgc:91987 antibody

Protein level used designations for GRB10

growth factor receptor-bound protein 10 , zgc:91987growth factor receptor-bound protein 10 , growth factor receptor-bound protein 10-like , GRB10 adapter protein , maternally expressed gene 1 protein , GRB10 adaptor protein , insulin receptor-binding protein Grb-IR , maternally expressed gene 1 , adapter protein , binds to insulin receptor and IGF1R

GENE ID SPECIES
100052610 Equus caballus
446167 Danio rerio
463410 Pan troglodytes
694786 Macaca mulatta
100151701 Xenopus (Silurana) tropicalis
100224775 Taeniopygia guttata
100381089 Xenopus laevis
100402854 Callithrix jacchus
100434903 Pongo abelii
100476882 Ailuropoda melanoleuca
100542734 Meleagris gallopavo
100564990 Anolis carolinensis
100599409 Nomascus leucogenys
14783 Mus musculus
498416 Rattus norvegicus
2887 Homo sapiens
607755 Canis lupus familiaris
100188977 Sus scrofa
407210 Bos taurus
100733471 Cavia porcellus
420948 Gallus gallus
101111275 Ovis aries
100355737 Oryctolagus cuniculus
Selected quality suppliers for anti-GRB10 (GRB10) Antibodies
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