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GNAT3 Proteins

(Guanine Nucleotide Binding Protein, alpha Transducing 3 (GNAT3))
Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase\; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide- 1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity.
GNAT3 Protein (AA 2-354) (His tag) GNAT3 Protein (AA 2-354) (His tag) GNAT3 Protein (AA 2-354) (His tag) (ABIN3135127)

Crystallography grade GNAT3 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, Crys, SDS, WB

GNAT3 Protein (AA 2-354) (His tag) GNAT3 Protein (AA 2-354) (His tag) GNAT3 Protein (AA 2-354) (His tag) (ABIN3092787)

Crystallography grade GNAT3 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, Crys, SDS, WB

GNAT3 Protein (Myc-DYKDDDDK Tag) GNAT3 Protein (Myc-DYKDDDDK Tag) GNAT3 Protein (Myc-DYKDDDDK Tag) (ABIN2722098)

GNAT3 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD

GNAT3 Proteins by Grade

Find GNAT3 Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

GNAT3 Proteins by Origin

Find GNAT3 Proteins for a variety of species such as anti-Human GNAT3, anti-Cow GNAT3, anti-Mouse GNAT3. The species listed below are among those available. Click on a link to go to the corresponding products.

GNAT3 Proteins by Source

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GNAT3 Proteins by Protein Type

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GNAT3 Proteins by Application

Find GNAT3 Proteins validated for a specific application such as ELISA, SDS, WB, Crys. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular GNAT3 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3135127
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3092787
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2722098
Quantity 20 μg
Datasheet Datasheet
Reactivity Rat
Source Yeast
Validations
Cat. No. ABIN1474568
Quantity 1 mg
Datasheet Datasheet
Reactivity Cow
Source Yeast
Validations
Cat. No. ABIN1459575
Quantity 1 mg
Datasheet Datasheet

Aliases for GNAT3 Proteins

G protein subunit alpha transducin 3 (GNAT3) Proteins
guanine nucleotide binding protein, alpha transducing 3 (Gnat3) Proteins
G protein subunit alpha transducin 3 (Gnat3) Proteins
GDCA Proteins
Ggust Proteins
gnat-3 Proteins
Gtn Proteins
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