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Guanine Nucleotide Binding Protein (G Protein), alpha Inhibiting Activity Polypeptide 2 (GNAI2) ELISA Kits

The protein encoded by GNAI2 is an alpha subunit of guanine nucleotide binding proteins (G proteins). Additionally we are shipping GNAI2 Antibodies (57) and GNAI2 Proteins (12) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse GNAI2 GNAI2 14678 P08752
Anti-Human GNAI2 GNAI2 2771 P04899
Anti-Rat GNAI2 GNAI2 81664 P04897
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More ELISA Kits for GNAI2 Interaction Partners

Mouse (Murine) Guanine Nucleotide Binding Protein (G Protein), alpha Inhibiting Activity Polypeptide 2 (GNAI2) interaction partners

  1. Kinocilium is essential for proper localization of Lgn, as well as Gai and aPKC, suggesting that cilium function plays a role in positioning of apical proteins critical for hearing.

  2. Galphai2 deficiency combined with cardiac beta1-adrenoceptor overexpression strongly impaired survival and cardiac function, leading to dilated cardiomyopathy.

  3. An essential role for Galpha(i2) in Smoothened-stimulated epithelial cell proliferation in the mammary gland.

  4. Platelet Galphai2 not only controls hemostatic and thrombotic responses but also is critical for the development of ischemia/reperfusion injury in vivo.

  5. Data show that disrupting resistance to inhibitors of cholinesterase 8A (Ric-8A (show RIC8A ELISA Kits)) expression in hematopoietic cells results in a loss of GTP-binding protein (show DRG1 ELISA Kits) alpha subunits Galphai2, Galphai3 (show GNAI3 ELISA Kits), and Galphaq (show GNAQ ELISA Kits).

  6. S1P (show S1PR1 ELISA Kits) sensitizes ICAPS through G-protein coupled S1P1 (show S1PR1 ELISA Kits) receptor activation of Galphai-PI3K-PKC (show PKC ELISA Kits)-p38 (show CRK ELISA Kits) signaling pathway in sensory neurons

  7. Myocardial ischemia promptly regulated cardiac mRNA and with a slight delay protein levels of both Galphai2 and Galphai3 (show GNAI3 ELISA Kits), indicating important roles for both Galphai isoforms.

  8. RGS (show PITX2 ELISA Kits) protein/Galphai2 interactions have an essential role in B lymphocyte (show AKAP17A ELISA Kits)-directed cell migration and trafficking.

  9. Data (including data from knockout mice) suggest that Gnai2 in islet beta-cells is necessary for up-regulation of insulin (show INS ELISA Kits) secretion in response to high glucose in presence of L-arginine (show GATM ELISA Kits) or L-ornithine.

  10. The absence of Galphai2 and Galphai3 (show GNAI3 ELISA Kits) in B cells profoundly disturbs the architecture of lymphoid organs with loss of B cell compartments in the spleen, thymus, lymph nodes, and gastrointestinal tract.

Human Guanine Nucleotide Binding Protein (G Protein), alpha Inhibiting Activity Polypeptide 2 (GNAI2) interaction partners

  1. Kinocilium is essential for proper localization of Lgn, as well as Gai and aPKC, suggesting that cilium function plays a role in positioning of apical proteins critical for hearing.

  2. Data strongly implicate GNAI2 as a critical regulator of oncogenesis and an upstream driver of cancer progression in ovarian carcinoma.

  3. Galpha (show SUCLG1 ELISA Kits)(i2) activates the TRPC4 (show TRPC4 ELISA Kits) channel by direct binding.

  4. Changes in ion selectivity and pore dilation of the TRPC4 (show TRPC4 ELISA Kits) channel elicited by the Galphai2 subunit, were studied.

  5. Galphai2(Q205L) regulates satellite cell differentiation into myotubes in a protein kinase C (show PKC ELISA Kits) - and histone deacetylase (show HDAC1 ELISA Kits) -dependent manner

  6. These results suggest that the extent of G-protein-mediated inhibition is significantly reduced in the K1336E mutant CaV2.1 (show CACNA1A ELISA Kits) Ca(2 (show CA2 ELISA Kits)+) channels

  7. The ubiquitination of Galphai2 and Galphaq (show GNAQ ELISA Kits) is suppressed by expression of Ric-8A (show RIC8A ELISA Kits). The suppression likely requires Ric-8A (show RIC8A ELISA Kits) interaction with these Galpha (show SUCLG1 ELISA Kits) proteins; the C-terminal truncation of Galphaq (show GNAQ ELISA Kits) and Galphai2 completely abrogates their interaction with Ric-8A (show RIC8A ELISA Kits).

  8. Gialpha2 plays an essential role in OXT (show OXT ELISA Kits) and EGF (show EGF ELISA Kits) signaling to induce prostate cancer cell migration.

  9. HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting Galpha (show SUCLG1 ELISA Kits)(i2) for degradation through ubiquitination

  10. Galphai2 as a novel claudin-5 (show CLDN5 ELISA Kits) partner required for TJ integrity in brain endothelial cells.

GNAI2 Antigen Profile

Antigen Summary

The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been detected for this gene, but the full-length nature of only two are known so far.

Gene names and symbols associated with GNAI2

  • guanine nucleotide binding protein (G protein), alpha inhibiting 2 (Gnai2) antibody
  • guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 (GNAI2) antibody
  • guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 (Gnai2) antibody
  • guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 (gnai2) antibody
  • guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b (gnai2b) antibody
  • C76432 antibody
  • fi21e06 antibody
  • Galphai2 antibody
  • GBI2 antibody
  • Gia antibody
  • gip antibody
  • Gnai-2 antibody
  • gnai2 antibody
  • gnai2b antibody
  • gnai3 antibody
  • H_LUCA15.1 antibody
  • H_LUCA16.1 antibody
  • wu:fi21e06 antibody
  • zgc:56690 antibody

Protein level used designations for GNAI2

adenylate cyclase-inhibiting G alpha protein , guanine nucleotide binding protein, alpha inhibiting 2 , guanine nucleotide-binding protein G(i) subunit alpha-2 , Gi2 protein alpha-subunit , GTP-binding regulatory protein Gi alpha-2 chain , guanine nucleotide-binding protein G(i), alpha-2 subunit , guanine nucleotide-binding regulatory protein alpha inhibitory subunit , Gi-alpha-2 protein , guanidine nucleotide binding protein, (G protein) , alpha inhibiting activity polypeptide 2 , guanine nucleotide binding protein, alpha inhibiting activity polypeptide 2 , G alpha inhibitory type 2 (a) , G alpha inhibitory type 2 (b) , GTP-binding protein (G-alpha-i2) , guanine nucleotide binding protein (G protein), alpha inhibiting 2 , guanine nucleotide binding protein, alpha inhibiting 3 , Galpha i2a , guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 , guanine nucleotide-binding protein Gi2 alpha-subunit

GENE ID SPECIES
14678 Mus musculus
100135529 Cavia porcellus
2771 Homo sapiens
442957 Canis lupus familiaris
397523 Sus scrofa
281791 Bos taurus
81664 Rattus norvegicus
779438 Xenopus laevis
396367 Gallus gallus
327650 Danio rerio
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