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Guanylate Cyclase 1, Soluble, beta 3 Proteins (GUCY1B3)

Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha subunit and a beta subunit, typically GUCY1B3, catalyzes conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide (NO) and nitrovasodilator drugs (Zabel et al., 1998 [PubMed 9742212]).[supplied by OMIM, Mar 2008].. Additionally we are shipping GUCY1B3 Antibodies (54) and GUCY1B3 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GUCY1B3 2983 Q02153
GUCY1B3 54195 O54865
GUCY1B3 25202 P20595
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Top GUCY1B3 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,787.67
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

GUCY1B3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Guanylate Cyclase 1, Soluble, beta 3 (GUCY1B3) Interaction Partners

Human Guanylate Cyclase 1, Soluble, beta 3 (GUCY1B3) interaction partners

  1. The kinetics of heme loss from oxidized sGC (show SGCB Proteins) was monitored by a new method based on the heme group de-quenching the fluorescence of FlAsH-EDT2.

  2. Dynamic interplay between hsp90 (show HSP90 Proteins), apo (show C9orf3 Proteins)-sGC (show SGCB Proteins)-beta1, and sGC (show SGCB Proteins)-alpha1 in response to NO is unprecedented and represent new steps by which cells can modulate the heme content and activity of sGC (show SGCB Proteins) for signaling cascades.

  3. Gene expression in dendritic cells of CCL5 (show CCL5 Proteins) and CXCL5 (show CXCL5 Proteins) as well as TIMP1 (show TIMP1 Proteins) and GUCY1B3 showed a significant increase within the first 4 days after trauma.

  4. The G-protein regulator LGN modulates the activity of the NO receptor soluble guanylate cyclase

  5. We concluded that the alpha-subunit (show POLG Proteins) and the beta(1)(191-619) domain exert structural strains on the heme domain.

  6. Data show that show that it is possible to directly monitor the sGC (show SGCB Proteins) haem oxidation state in intact cells. By inserting the TC motif into the coding sequence of the beta1 subunit of sGC (show SGCB Proteins) in transiently transfected Chinese hamster ovary cells.

  7. recombinant soluble guanylate cyclase (sGC (show SGCB Proteins)) beta1 subunit and truncated N-terminal fragments expressed in E. coli; studied interaction between NO and sGC (show SGCB Proteins) and schematic mechanism was proposed; study provides insights into structure and NO-binding of sGC (show SGCB Proteins)

  8. Results show that NOGCbeta1 and GC-A (show NPR1 Proteins) interact and that NOGCbeta1 regulates atrial natriuretic peptide (show NPPA Proteins) signaling in HK-2 (show HK2 Proteins) cells.

  9. Although soluble guanylate cyclase(sGC (show SGCB Proteins)) beta1-subunit expression was increased in mononuclear cells from patients with erectile dysfunction, the sGC (show SGCB Proteins) activity was reduced

Pig (Porcine) Guanylate Cyclase 1, Soluble, beta 3 (GUCY1B3) interaction partners

  1. expression of sGC (show NPR1 Proteins) beta(1)-subunit in pulmonary arteries increased with postnatal age both at the level of mRNA and protein

Cow (Bovine) Guanylate Cyclase 1, Soluble, beta 3 (GUCY1B3) interaction partners

  1. These results suggest a means by which the hsp90beta (show HSP90AB1 Proteins) interaction could prevent apo (show C9orf3 Proteins)-sGCbeta1 from associating with its partner sGCalpha1 subunit while enabling structural changes to assist heme insertion into the H-NOX domain.

  2. We concluded that the alpha-subunit (show POLG Proteins) and the beta(1)(191-619) domain exert structural strains on the heme domain.

Mouse (Murine) Guanylate Cyclase 1, Soluble, beta 3 (GUCY1B3) interaction partners

  1. Apo (show C9orf3 Proteins)-sGC (show NPR1 Proteins) mice expressing haem-free sGC (show NPR1 Proteins) are viable and develop hypertension. The haemodynamic effects of NO are abolished, but those of the sGC (show NPR1 Proteins) activator cinaciguat are enhanced.

  2. sGC (show NPR1 Proteins) and cGMP-dependent signaling are necessary and sufficient for HNO-induced vasodilation in vivo but are not required for positive inotropic action.

  3. Deletion of GCbeta1 specifically in smooth muscle cells abolishes NO-induced corpus cavernosum relaxation but does not lead to infertility.

  4. A VASP (show VASP Proteins) to Rac (show AKT1 Proteins) to soluble guanylyl cyclase negative feedback loop limited cGMP production, thereby regulating adipogenesis and energy homeostasis.

  5. These data suggests a novel physiological role for PDE5 (show PDE5A Proteins) in restricting the effects of NOS3 (show NOS3 Proteins)/sGC (show NPR1 Proteins)/PKG (show PRKG1 Proteins) signaling pathway to modulating beta-AR stimulated I(Ca), while limiting effects on cardiac contraction.[sGC (show NPR1 Proteins)]

  6. Pressure overload results in translocation of sGC (show NPR1 Proteins) out of membrane microdomains, depressing NO/heme-dependent activation in the heart, consistent with enhanced oxidation.

  7. Important roles of sGC (show NPR1 Proteins) in stimulating platelet activation and in vivo thrombosis and hemostasis.

  8. findings identify a crucial role of the NO/sGCalpha1beta1/cGMP pathway in modulating lymphatic vessel function [soluble guanylate cyclase alpha1beta1]

  9. Knockout of GCbeta1 completely disrupts the NO/cGMP signaling cascade and provides evidence for the unique role of NO-GC as NO receptor.

  10. cGMP generated by sGC (show NPR1 Proteins)(alpha)(1)beta(1) protects against cardiac dysfunction and mortality in murine inflammatory shock models

GUCY1B3 Protein Profile

Protein Summary

Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha subunit and a beta subunit, typically GUCY1B3, catalyzes conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide (NO) and nitrovasodilator drugs (Zabel et al., 1998

Gene names and symbols associated with GUCY1B3

  • guanylate cyclase 1, soluble, beta 3 (GUCY1B3)
  • guanylate cyclase 1, soluble, beta 3 (gucy1b3)
  • guanylate cyclase, soluble, beta 1 (Gycbeta1)
  • soluble guanylyl cyclase beta subunit (gucy1b3)
  • guanylate cyclase 1, soluble, beta 3 (Gucy1b3)
  • AMGC1 protein
  • AmsGC-beta1 protein
  • AmsGCbeta1 protein
  • GB20021 protein
  • GC-S-beta-1 protein
  • GC-SB3 protein
  • GCbeta1 protein
  • GUC1B3 protein
  • GUCB3 protein
  • GUCSB3 protein
  • Gucy1b1 protein
  • gucy1b3 protein
  • SGC protein
  • SGCB1 protein

Protein level used designations for GUCY1B3

guanylate cyclase 1, soluble, beta 3 , guanylate cyclase soluble subunit beta-1-like , guanylate cyclase soluble subunit beta-1 , soluble guanylyl cyclase beta subunit , GCS-beta-1 , GCS-beta-3 , guanylate cyclase soluble subunit beta-3 , soluble guanylate cyclase small subunit , soluble guanylate cyclase 1 beta 3 , soluble guanylyl cyclase beta 1 subunit , NO-sensitive GC beta 1 subunit , nitric oxide-sensitive guanylyl cyclase beta 1 subunit , NO-sensitive guanylyl cyclase beta 1 subunit , beta 1 sGC , soluble guanylate cyclase beta-1 subunit , guanylate cyclase, soluble, beta 1

GENE ID SPECIES
422408 Gallus gallus
461565 Pan troglodytes
100379900 Xenopus (Silurana) tropicalis
100395297 Callithrix jacchus
100424944 Macaca mulatta
408880 Apis mellifera
100049178 Oryzias latipes
100583335 Nomascus leucogenys
432281 Xenopus laevis
2983 Homo sapiens
553102 Canis lupus familiaris
444999 Sus scrofa
282433 Bos taurus
54195 Mus musculus
25202 Rattus norvegicus
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