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anti-Guanylate Cyclase Activator 1B (Retina) (GUCA1B) Antibodies

The protein encoded by GUCA1B is a calcium-binding protein that activates photoreceptor guanylate cyclases. Additionally we are shipping GUCA1B Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GUCA1B 107477 Q8VBV8
GUCA1B 2979 Q9UMX6
GUCA1B 286851 P51177
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Top anti-GUCA1B Antibodies at antibodies-online.com

Showing 10 out of 47 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB GUCA1B Antibody (N-term) (ABIN1881399) western blot analysis in A549 cell line lysates (35 µg/lane). This demonstrates the GUCA1B antibody detected the GUCA1B protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-GUCA1B Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: U937 cell lysate WB Suggested Anti-GUCA1B  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500  Positive Control: U937 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Biotin ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged GUCA1B is 0.1 ng/ml as a capture antibody. Western Blot detection against Immunogen (37.62 KDa) . 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB   100 μL Log in to see 14 to 21 Days
$269.50
Details
Human Rabbit Un-conjugated ELISA, WB   200 μL Log in to see 11 to 16 Days
$532.71
Details
Human Rabbit APC ELISA, WB   200 μL Log in to see 16 Days
$710.29
Details
Human Rabbit HRP ELISA, WB   200 μL Log in to see 16 Days
$710.29
Details

GUCA1B Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)


Human ,
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Cow (Bovine)


Top referenced anti-GUCA1B Antibodies

  1. Human Polyclonal GUCA1B Primary Antibody for WB - ABIN611262 : Chen, Chédotal, He, Goodman, Tessier-Lavigne: Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. in Neuron 1997 (PubMed)
    Show all 3 references for ABIN611262

  2. Human Polyclonal GUCA1B Primary Antibody for WB - ABIN1881399 : Sato, Nakazawa, Usui, Tanimoto, Abe, Ohguro: Mutations in the gene coding for guanylate cyclase-activating protein 2 (GUCA1B gene) in patients with autosomal dominant retinal dystrophies. in Graefe's archive for clinical and experimental ophthalmology 2005 (PubMed)
    Show all 3 references for ABIN1881399

More Antibodies against GUCA1B Interaction Partners

Mouse (Murine) Guanylate Cyclase Activator 1B (Retina) (GUCA1B) interaction partners

  1. The GCAP1 and GCAP2 binding site(s) overlaps within the kinase homology and/or dimerization domains of retinal GC1.

  2. This study identifies a new mechanism governing GCAP2 (show GUCA2B Antibodies) subcellular distribution in vivo, closely related to disease.

  3. Overexpression of guanylate cyclase activating protein 2 in rod photoreceptors in vivo leads to morphological changes at the synaptic ribbon.

  4. GCAP (show GUCA1A Antibodies)-activated native retinal membrane (Ret (show RET Antibodies))GC1 and RetGC2 (show GUCY2F Antibodies) are less sensitive to inhibition by calcium ions in the presence of GCAP1 (show GUCA1A Antibodies) than GCAP2 (show GUCA2B Antibodies).

  5. GCAP2 (show GUCA2B Antibodies) is a prime candidate for mediating Ca2 (show CA2 Antibodies)+-dependent dynamic changes of synaptic ribbons in photoreceptor synapses

  6. GCAP (show GUCA1A Antibodies) functions in intact photoreceptors [review]

  7. GCAP2 (show GUCA2B Antibodies) regulation of guanylyl cyclase activity quickens the recovery of flash and step responses and adjusts the operating range of rods to higher intensities of ambient illumination

  8. Prolonged illumination up-regulates retinal arrestin (show SAG Antibodies) and Guca1a (show GUCA1A Antibodies)/b: a novel mechanism for light adaptation.

Cow (Bovine) Guanylate Cyclase Activator 1B (Retina) (GUCA1B) interaction partners

  1. The C-terminal segment in GCAP2 confers target selectivity, facilitates membrane binding and provides sensitivity of the membrane localization of the protein to phosphorylation by rhodopsin kinase (show GRK1 Antibodies).

  2. Based on the distance constraints imposed by the cross-links, the study derived a 3D-structural model of the GCAP2 homodimer.

  3. Data suggest that dimerization domain of GUCY2D (show GUCY2D Antibodies) operates as a calcium-sensitive regulatory module; GUCY2D (show GUCY2D Antibodies) requires correct conformation of monomer-monomer interface for interaction with guanylate cyclase activating proteins (GCAP1 (show GUCA1A Antibodies); GCAP2).

  4. interaction between N-terminally myristoylated GCAP-2 and a peptide derived from the catalytic domain of full-length ROS-GC 1

  5. Ca2 (show CA2 Antibodies)+ exerted a stabilizing effect on both myristoylated and non-myristoylated forms of the protein, which was significantly stronger for myristoylated GCAP2.

  6. GCAP2 is a prime candidate for mediating Ca2 (show CA2 Antibodies)+-dependent dynamic changes of synaptic ribbons in photoreceptor synapses

  7. Findings show that the sequence motif of the core GCAP2-modulatory site is Tyr965-Asn981 of rod outer segment membrane guanylate cyclase (show GUCY2D Antibodies) type 1 (ROS-GC1); this site is absolutely specific for GCAP2 and does not overlap with the GCAP1 (show GUCA1A Antibodies)-modulated site.

  8. Our data indicate that the Ca(2 (show CA2 Antibodies)+)-sensitivity of GCAP2 is significantly controlled by its third Ca(2 (show CA2 Antibodies)+)-binding site, EF-hand 3.

Human Guanylate Cyclase Activator 1B (Retina) (GUCA1B) interaction partners

  1. Dimerization domain of RETGC1 (show GUCY2D Antibodies) is an essential part of GCAP1 (show GUCA1A Antibodies) and GCAP2 binding interface.

  2. The GCAP1 and GCAP2 binding site(s) overlaps within the kinase homology and/or dimerization domains of retinal GC1.

  3. The absence of clearly pathogenic mutations in the selected patient group suggests that the GUCA1B gene is a minor cause for retinal degenerations in Europeans or North-Americans.

  4. Mutation in the GCAP 2 gene can cause one form of autosomal dominant retinal dystrophy (show MERTK Antibodies), with variable phenotypic expression and incomplete penetrance.

GUCA1B Antigen Profile

Protein Summary

The protein encoded by this gene is a calcium-binding protein that activates photoreceptor guanylate cyclases. This gene may have arisen due to a gene duplication event since there is a highly similar gene clustered with it on chromosome 6. Mutations in this gene can cause a form of retinitis pigmentosa.

Gene names and symbols associated with GUCA1B

  • guanylate cyclase activator 1B (retina) (GUCA1B) antibody
  • guanylate cyclase activator 1B (retina) (LOC100223999) antibody
  • guanylate cyclase activator 1B (retina) (guca1b) antibody
  • guanylate cyclase activator 1B (Guca1b) antibody
  • BC018258 antibody
  • GCAP2 antibody
  • GUCA1B antibody
  • GUCA2 antibody
  • RP48 antibody

Protein level used designations for GUCA1B

guanylate cyclase activator 1B (retina) , GCAP 2 , GCAP2 (retina) , guanylyl cyclase-activating protein 2 , retinal guanylyl cyclase activator protein p24 , guanylate cyclase-activating protein, photoreceptor 2 , calcium binding protein , guanylate cyclase activating protein 2

GENE ID SPECIES
472007 Pan troglodytes
481801 Canis lupus familiaris
695658 Macaca mulatta
100223999 Taeniopygia guttata
100379842 Xenopus (Silurana) tropicalis
107477 Mus musculus
286851 Bos taurus
2979 Homo sapiens
419864 Gallus gallus
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