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GUCA2B encodes a member of the guanylin family, and is expressed in the stomach and intestine. Additionally we are shipping GUCA2B Antibodies (55) and GUCA2B Kits (15) and many more products for this protein.
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In obese mice UGN expression was decreased, whereas leptin (show LEP Proteins) treatment up-regulated UGN levels in duodenum in these genetically modified mice compared to WT.
UGN exerts its inhibitory activity on the prendrin gene promoter likely via heat shock factor 1 action at a defined heat shock element site.
findings establish a role for uroguanylin in an enteric-renal communication axis as well as a fundamental principle of this axis in the maintenance of salt homeostasis in vivo
act on the mouse kidney, in part, through a cGMP-dependent, GC-C (show GUCY2C Proteins)-independent mechanism, causing significant natriuresis by renal tubular processes.
existence of two signaling pathways for guanylin (show GUCA2A Proteins) peptides in principal cells of mouse cortical collecting duct of kidney
Role for uroguanylin in fluid homeostasis and as an integral component of a signaling mechanism that mediates changes in Na excretion in response to an enteral salt loading.
Uroguanylin concentrations are increased in patients with chronic renal failure, nephrotic syndrome, or those on dialysis.
This gene encodes a member of the guanylin family, and is expressed in the stomach and intestine. This protein functions as an endogenous ligand for the guanylate cyclase-C receptor and stimulates an increase in cyclic GMP, a key component of several intracellular signal transduction pathways. It maybe involved in salt and water secretion into the intestinal lumen as well as the renal tubules, and thus regulate electrolyte homeostasis in these tissues.
guanylate cyclase activator 2B (uroguanylin)
, guanylate cyclase activator 2B
, guanylate cyclase activator 2b (retina)
, granule cell antiserum positive 2
, guanylyl cyclase activating peptide II