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Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Additionally we are shipping HLX Proteins (6) and many more products for this protein.
Showing 10 out of 59 products:
Human Polyclonal HLX Primary Antibody for IF, ELISA - ABIN1533893
Kennedy, Rayner, Morris: Genomic structure, promoter sequence, and revised translation of human homeobox gene HLX1. in Genomics 1995
Show all 2 references for ABIN1533893
Human Polyclonal HLX Primary Antibody for IF, WB - ABIN516528
Martin, Popov, Aguilo, OLoghlen, Raguz, Snijders, Dharmalingam, Li, Thymiakou, Carroll, Zeisig, So, Peters, Episkopou, Walsh, Gil: Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK?a regulation. in The EMBO journal 2013
Hlx1 selectively marks sprouting endothelial cells during zebrafish development.Hlx1 is required for intersegmental vessel angiogenesis in zebrafish embryos.Hlx1 cell-autonomously maintains endothelial stalk cell potential.
HLX1 is significantly downregulated in HCC (show FAM126A Antibodies) and suggests that HLX1 has suppressive effects on HCC (show FAM126A Antibodies) growth and metastasis. Accordingly, HLX1 may act as a tumor suppressor in HCC (show FAM126A Antibodies).
Studies have identified HLX as a novel key transcription factor involved in the regulation of early hematopoiesis and AML (show RUNX1 Antibodies) pathogenesis.
The expression levels of Hlx, T-bet, and IFN-gamma (show IFNG Antibodies) were significantly decreased.
Data suggest that HLX1 is downstream mediator of hepatocyte growth factor- (HGF (show HGF Antibodies)-) induced cell survival, cell proliferation, and invasive properties of trophoblast cells; thus, both HGF (show HGF Antibodies) and HLX1 appear to be involved in normal placental development.
This study identifies HLX as a key regulator in immature hematopoietic and leukemia cells and as a prognostic marker and therapeutic target in acute myeloid leukemia (show BCL11A Antibodies).
This study investigated the influence of TBX21 and HLX1 single nucleotide polymorphisms (SNPs), which have previously been shown to be associated with asthma, on T(H)1/T(H)2 lineage cytokines at birth.
a functional polymorphism in HLX in combination with the TBX21 polymorphism is also associated with the prognosis of Graves' disease.
These data suggest that HLX may function to balance attractive with repulsive vessel guidance by up-regulating UNC5B (show UNC5B Antibodies) and to down-modulate sprouting under normoxic conditions.
HLX is a mediator of HGF/c-met-dependent trophoblast migration but is not involved in the regulation of trophoblast invsion.
Cell cycle regulatory genes RB1 (show RB1 Antibodies), MYC (show MYC Antibodies), CCNB1 (show CCNB1 Antibodies), ELK1 (show ELK1 Antibodies), JUN (show JUN Antibodies), and CDKN1C (show CDKN1C Antibodies), which control important trophoblast cell functions, are targets of HLX.
methyl-CpG-binding domain protein 2 (MBD2 (show MBD2 Antibodies)), an epigenetic regulator, controls autoimmunity and EAE through T-bet/Hlx.
Hlx regulates sprouting in vitro, but its role in sprouting is nonessential in vivo. HLX is regulated by shear stress and a subtle defect in vascular remodeling is present in knockout embryos.
Results shown that over-expressed Hlx in DC2.4 up-regulated the transcription and expression of IFN-gamma, increased the expression of maturation makers including CD40, CD80, CD86, MHC-I and MHC-II
Transient over-expression of Hlx in DC2.4 promotes DC2.4 maturation and up-regulates IL-12 (show IL12A Antibodies), IL-10 (show IL10 Antibodies) and TGF-beta (show TGFB1 Antibodies) expression. H1x (show H1FX Antibodies) modified DC2.4 cells seem to function as regulatory dendritic cells
Hlx expression in activated NK cells temporally controls and limits the monokine-induced production of interferon-gamma (show IFNG Antibodies)
Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity).
, H2.0-like homeobox protein
, H2.0-like homeo box 1
, H2.0-like homeo box-1
, H2.0-like homeobox 1
, homeobox protein HB24
, homeobox protein HLX1