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Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Additionally we are shipping H2A Histone Family, Member Y2 Proteins (4) and many more products for this protein.
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Human Polyclonal H2AFY2 Primary Antibody for EIA, FACS - ABIN952667
Sporn, Kustatscher, Hothorn, Collado, Serrano, Muley, Schnabel, Ladurner: Histone macroH2A isoforms predict the risk of lung cancer recurrence. in Oncogene 2009
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Human Polyclonal H2AFY2 Primary Antibody for FACS, WB - ABIN654683
Xu, Zheng, Isaacs, Wiley, Wiklund, Sun, Kader, Li, Purcell, Kim, Hsu, Stattin, Hugosson, Adolfsson, Walsh, Trent, Duggan, Carpten, Grönberg, Isaacs: Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. in Proceedings of the National Academy of Sciences of the United States of America 2010
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expression of histone macroH2A1.1 (show H2AFY Antibodies) and macroH2A2 predicts lung cancer recurrence.
Our results reveal unanticipated dynamic behavior of the MacroH2A2 variant in pluripotent cells, and provide a resource for future studies of tissue-specific histone dynamics in vivo.
Data show that MacroH2A (show H2AFY Antibodies).1 and macroH2A (show H2AFY Antibodies).2 regulate gene expression with them acting synergistically on the expression of some genes and apparently having opposing effects on others.
macroH2A1 (show H2AFY Antibodies) and macroH2A2, together with histone 3 lysine 27 methylated 3, co-occupy pluripotency genes in wild-type (wt) fibroblasts.
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.
core histone macro-H2A.2
, H2A histone family, member Y2
, core histone macroH2A2.2
, H2A histone family, member Y-like
, histone macroH2A2