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HBS1L encodes a member of the GTP-binding elongation factor family. Additionally we are shipping HBS1-Like (S. Cerevisiae) Antibodies (76) and HBS1-Like (S. Cerevisiae) Proteins (3) and many more products for this protein.
Knowledge of the interacting residues in the yeast complexes allowed identification of a splice variant of human HBS1-Like as a Ski7-like exosome-binding protein, revealing the evolutionary conservation of this cytoplasmic cofactor.
high-risk genotypes of six Hb F-associated SNPs, rs9376090, rs7776054, rs9399137, rs9389268, rs9402685 in the HBS1L-MYB (show MYB ELISA Kits) intergenic region and rs189984760 in the BCL11A (show BCL11A ELISA Kits) locus, showed association with high Hb F levels
The HBS1L-MYB (show MYB ELISA Kits) region contains two HbF QTLs, HMIP (show MIPEP ELISA Kits)-2A and HMIP (show MIPEP ELISA Kits)-2B (HBS1L-MYB (show MYB ELISA Kits) intergenic polymorphisms A and B) HMIP (show MIPEP ELISA Kits)-A is tagged by the SNP rs9399137, with the C" allele promoting HbF. Only 1 sickle cell patient had this allele. HMIP (show MIPEP ELISA Kits)-B was tagged in these patients by rs4895441and represented Amerindian ethnic origin.
we find that the interaction of UPF2 with UPF3b interferes with the assembly of the UPF2-eRF3 complex, and that UPF2 binds UPF3b more strongly than eRF3
eRF3 neither interacts with the rRNA ribosephosphate backbone nor dissociates from the complex after GTP (show AK3 ELISA Kits) hydrolysis at translation termination.
The study compares polymorphism at BCL11A (show BCL11A ELISA Kits) to HBS1L-MYB (show MYB ELISA Kits) loci and explains less of the variance in HbF in patients with sickle cell disease in Cameroon.
Genetic variants of HBS1L is associated with sickle cell disease.
Several HBS1L-MYB (show MYB ELISA Kits) intergenic variants reduce transcription factor binding, affecting interactions with MYB (show MYB ELISA Kits) and MYB (show MYB ELISA Kits) expression levels. This may explain the genetic association of HBS1L-MYB (show MYB ELISA Kits) intergenic polymorphisms with erythroid traits and HbF levels.
The non-stop (show USP22 ELISA Kits) decay mechanism exists in mammalian cells and involves Hbs1, Dom34, and the exosome-Ski (show SKI ELISA Kits) complex.
Studies indicate that single nucleotide polymorphisms (SNPs) in regions of BCL11A (show BCL11A ELISA Kits) and HBS1L-MYB (show MYB ELISA Kits) intergenic polymorphism are the major modifiers of HbF in African Americans.
This gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
HBS1-like (S. cerevisiae)
, HBS1-like protein
, ef-1 alpha
, elongation factor 1-alpha
, ERF3-similar protein
, Hsp70 subfamily B suppressor 1-like protein
, eukaryotic release factor 3