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anti-HCLS1 Associated Protein X-1 (HAX1) Antibodies

The protein encoded by HAX1 is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. Additionally we are shipping HAX1 Proteins (11) and HAX1 Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HAX1 10456 O00165
HAX1 291202 Q7TSE9
HAX1 23897 O35387
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Top anti-HAX1 Antibodies at antibodies-online.com

Showing 10 out of 122 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-HAX1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: COLO205 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB HAX1 Antibody (C-term) (ABIN656245) immunohistochemistry analysis in formalin fixed and paraffin embedded human esophageal carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Imunohistochemistry analysis in formalin fixed and paraffin embedded human esophageal carcinoma reacted with HAX1 Antibody (C-term) followed by peroxidase conjugation of the secondary antibody and DAB staining. Western blot analysis of HAX1 Antibody (C-term) in NCI-H292 cell line lysates (35ug/lane). This demonstrates the HAX1 antibody detected the HAX1 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated EIA, WB 0.1 mL Log in to see 6 to 8 Days
$412.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of Hax1b in mouse brain tissue lysate with AP30393PU-N Hax1b antibody at (A) 1 and (B) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Mouse Un-conjugated WB Western Blot analysis of HAX1 expression in transfected 293T cell line by HAX1 monoclonal antibody (M04), clone 1D2. Lane 1: HAX1 transfected lysate(31.6 KDa). Lane 2: Non-transfected lysate. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Mouse Un-conjugated IF, IP, IHC, WB Western blot analysis of HAX-1 on Jurkat cell lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of anti-HAX-1 antibody. Immunofluorescent staining of HeLa cells with anti-HAX-1 antibody. 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-HAX1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Human heart WB Suggested Anti-HAX1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: Human heart 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, WB EB09160 (1µg/ml) staining of Human Testis lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details

HAX1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-HAX1 Antibodies

  1. Human Monoclonal HAX1 Primary Antibody for WB - ABIN393488 : Burnicka-Turek, Kata, Buyandelger, Ebermann, Kramann, Burfeind, Hoyer-Fender, Engel, Adham: Pelota interacts with HAX1, EIF3G and SRPX and the resulting protein complexes are associated with the actin cytoskeleton. in BMC cell biology 2010 (PubMed)
    Show all 5 references for ABIN393488

  2. Human Polyclonal HAX1 Primary Antibody for EIA, IHC (p) - ABIN952684 : Johns, Doceul, Everett, Crooke, Charleston, Seago: The classical swine fever virus N-terminal protease N(pro) binds to cellular HAX-1. in The Journal of general virology 2010 (PubMed)
    Show all 3 references for ABIN952684

  3. Human Monoclonal HAX1 Primary Antibody for EIA, WB - ABIN400856 : Klein, Grudzien, Appaswamy, Germeshausen, Sandrock, Schäffer, Rathinam, Boztug, Schwinzer, Rezaei, Bohn, Melin, Carlsson, Fadeel, Dahl, Palmblad, Henter, Zeidler, Grimbacher, Welte: HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease). in Nature genetics 2006 (PubMed)
    Show all 2 references for ABIN400856

  4. Human Polyclonal HAX1 Primary Antibody for WB - ABIN375096 : Chao, Parganas, Boyd, Hong, Opferman, Ihle: Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons. in Nature 2008 (PubMed)

  5. Human Monoclonal HAX1 Primary Antibody for IF, IP - ABIN968198 : Suzuki, Demoliere, Kitamura, Takeshita, Deuschle, Watanabe: HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases. in Journal of immunology (Baltimore, Md. : 1950) 1997 (PubMed)

  6. Cow (Bovine) Polyclonal HAX1 Primary Antibody for WB - ABIN2784795 : Lees, Hart, Marshall: Existence of multiple isoforms of HS1-associated protein X-1 in murine and human tissues. in Journal of molecular biology 2008 (PubMed)

  7. Human Polyclonal HAX1 Primary Antibody for IHC (p), WB - ABIN656245 : Han, Goldstein, Hou, Froelich, Watkins, Rabinowich: Deregulation of mitochondrial membrane potential by mitochondrial insertion of granzyme B and direct Hax-1 cleavage. in The Journal of biological chemistry 2010 (PubMed)

More Antibodies against HAX1 Interaction Partners

Human HCLS1 Associated Protein X-1 (HAX1) interaction partners

  1. Kv3.3 (show KCNC3 Antibodies) regulates Arp2 (show ACTR2 Antibodies)/3-dependent cortical actin nucleation mediated by Hax-1; resulting cortical actin structures interact with the channel's gating machinery to slow its inactivation rate during sustained membrane depolarizations; a mutation that leads to late-onset spinocerebellar ataxia (show USP14 Antibodies) type 13.

  2. Results show that mRNA and protein levels of HAX-1 in prostate cancer cell lines were significantly higher and inhibits cell apoptosis through caspase-9 (show CASP9 Antibodies) inactivation.

  3. HAX-1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation.

  4. HAX1 knockdown significantly decreased the proliferation. In addition, the expression levels of ki67 (show MKI67 Antibodies) and phosphorylatedakt were inhibited following HAX1 knockdown.

  5. HAX-1 was significantly elevated in laryngeal carcinoma.

  6. Authors showed that HAX1 promotes auto-ubiquitination and degradation of cIAPs by facilitating the intermolecular homodimerization of RING finger (show PCGF1 Antibodies) domain.

  7. HAX-1 is involved in mRNA processing as an element of P-body interaction network.

  8. HAX1 mutation is associated with severe congenital neutropenia.

  9. HAX1 is a proto-oncogene (show RAB1A Antibodies) in mantle cell lymphoma.

  10. anti-apoptotic role of HAX-1 versus BCL-XL (show BCL2L1 Antibodies) in cytokine-dependent bone marrow-derived cells

Mouse (Murine) HCLS1 Associated Protein X-1 (HAX1) interaction partners

  1. The hydrophilic sequences within loop 2, and the matrix-localized hydrophilic domain of UCP3 (show UCP3 Antibodies), were necessary for binding to Hax-1 at the C-terminal domain, adjacent to the mitochondrial inner membrane.

  2. Protease Omi (show HTRA2 Antibodies) impairs mitochondrial function by cleaving Hax-1, which induces apoptosis in oxygen-glucose deprivation and reoxygenation -treated N2a cells and causes reperfusion injury in middle cerebral artery occlusion mice.

  3. Knockdown of HAX1 and EB2 (show MAPRE2 Antibodies) in skin epidermal cells stabilizes focal adhesions and impairs epidermal migration.

  4. These findings reveal the role of HAX-1 in regulating cyclophilin-D (show PPIF Antibodies) levels via an Hsp90 (show HSP90 Antibodies)-dependent mechanism, resulting in protection against activation of mPTP (show PTPN2 Antibodies) and subsequent cell death responses.

  5. anti-apoptotic role of HAX-1 versus BCL-XL (show BCL2L1 Antibodies) in cytokine-dependent bone marrow-derived cells

  6. The expression of Hax-1 in normal brain tissue and reduction of Hax-1 in ischemic brain tissue indicate its possible involvement in pathophysiological functions in the brain.

  7. Cardiac ischemia-reperfusion injury is associated with decreases in HAX-1 levels. Overexpression of HAX-1 promotes cardiomyocyte survival, via its interaction with Hsp90 (show HSP90 Antibodies) and specific inhibition of IRE-1 (show ERN1 Antibodies) signaling at the ER/sarcoplasmic reticulum.

  8. Focal cerebral ischemia significantly decreased cytosolic accumulation of HAX-1, induced an upregulation of HtrA2 (show HTRA2 Antibodies), an upregulation of AIF (show AIFM1 Antibodies) and activation of caspase-3 (show CASP3 Antibodies)

  9. HAX1 deficiency: impact on lymphopoiesis and B-cell development.

  10. HAX-1 is a multifaceted antiapoptotic protein localizing in the mitochondria and the sarcoplasmic reticulum of striated (show NSDHL Antibodies) muscle cells

HAX1 Antigen Profile

Protein Summary

The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with HAX1

  • HCLS1 associated protein X-1 (HAX1) antibody
  • HCLS1-associated protein X-1 (hax1) antibody
  • zgc:92196 (zgc:92196) antibody
  • HCLS1 associated protein X-1 (LOC100348155) antibody
  • HCLS1 associated protein X-1 (Hax1) antibody
  • HCLS1 associated X-1 (Hax1) antibody
  • HAX-1 antibody
  • hax1 antibody
  • HCLSBP1 antibody
  • Hs1bp1 antibody
  • HSP1BP-1 antibody
  • mHAX-1s antibody
  • SCN3 antibody
  • SIG-111 antibody
  • Silg111 antibody

Protein level used designations for HAX1

HCLS1 associated protein X-1 , HCLS1-associated protein X-1 , HAX-1 , HCLS1 (and PKD2) associated protein , HS1 binding protein , HS1-associating protein X-1 , HS1-binding protein 1 , HSP1BP-1 , HS1-associated protein X-1

GENE ID SPECIES
457347 Pan troglodytes
100194877 Salmo salar
436609 Danio rerio
100348155 Oryctolagus cuniculus
10456 Homo sapiens
480134 Canis lupus familiaris
506895 Bos taurus
291202 Rattus norvegicus
23897 Mus musculus
Selected quality suppliers for anti-HAX1 (HAX1) Antibodies
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