anti-HECT, C2 and WW Domain Containing E3 Ubiquitin Protein Ligase 2 (HECW2) Antibodies

E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Additionally we are shipping HECW2 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HECW2 316395  
HECW2 57520 Q9P2P5
HECW2 329152 Q6I6G8
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Top anti-HECW2 Antibodies at antibodies-online.com

Showing 10 out of 47 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from LOVO/HepG2 cells, using HECW2 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 6 to 7 Days
$221.76
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of HECW2 Antibody (Center) in mouse brain tissue lysates (35ug/lane). This demonstrates the HECW2 antibody detected the HECW2 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 16 Days
$175.80
Details
Human Rabbit Un-conjugated WB HECW2 Antibody (Center)  western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the HECW2 antibody detected the HECW2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged HECW2 is approximately 0.3 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated IC, IF, WB Immunofluorescent analysis of HECW2 staining in A549 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Western blot analysis of HECW2 expression in A549 (A), NIH3T3 (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Chicken Goat Un-conjugated ELISA   100 μg Log in to see 7 to 9 Days
$507.83
Details
Human Rabbit Un-conjugated IHC, IHC (p) Immunohistochemistry: NEDL2 Antibody [NBP1-92174] - Staining of human lung shows strong cytoplasmic positivity in subsets of alveolar cells. Immunocytochemistry/Immunofluorescence: NEDL2 Antibody  - Staining of human cell line A-431 shows localization to endoplasmic reticulum. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged HECW2 is approximately 0.3ng/ml as a capture antibody. Western Blot detection against Immunogen (37.73 KDa) . 100 μg Log in to see 11 to 12 Days
$430.00
Details

HECW2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Mouse (Murine) ,
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More Antibodies against HECW2 Interaction Partners

Human HECT, C2 and WW Domain Containing E3 Ubiquitin Protein Ligase 2 (HECW2) interaction partners

  1. HECW2, a novel EC ubiquitin E3 ligase, plays a critical role in stabilizing endothelial cell-to-cell junctions by regulating AMOT (show AMOT Antibodies)-like 1 (AMOTL1 (show AMOTL1 Antibodies)) stability.

  2. HECW2 is an ubiquitin ligase that stabilises p73 (show TP73 Antibodies), a crucial mediator of neurodevelopment and neurogenesis. This study implicates pathogenic genetic variants in HECW2 as potential causes of neurodevelopmental disorders in humans.

  3. This work lends further support to previously identified candidate gene HECW2 as a novel candidate gene in intellectual disability and epilepsy. In 39 patient-parent trios, 29 de novo mutations in coding sequence were identified.

  4. Low HECW2 expression is associated with cervical cancer.

  5. NEDL2 is a novel substrate of APC (show APC Antibodies)/C-Cdh1 (show CDH1 Antibodies) as cells exit mitosis and functions as a regulator of the metaphase to anaphase transition

Mouse (Murine) HECT, C2 and WW Domain Containing E3 Ubiquitin Protein Ligase 2 (HECW2) interaction partners

  1. NEDL2 positively regulates enteric neural precursor proliferation through the GDNF/Akt (show AKT1 Antibodies) signaling pathway.

  2. Grk2 (show ADRBK1 Antibodies) phosphorylates the C terminus of the Na-channel beta subunit (show POLG Antibodies) and renders the channels insensitive to inhibition by Nedd4-2 (show NEDD4L Antibodies)

HECW2 Antigen Profile

Protein Summary

E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (By similarity).

Gene names and symbols associated with HECW2

  • HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 (Hecw2) antibody
  • HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 (HECW2) antibody
  • E3 ubiquitin-protein ligase HECW2 (LOC531691) antibody
  • HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2b (hecw2b) antibody
  • HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 (hecw2) antibody
  • A730039N16Rik antibody
  • D030049F17Rik antibody
  • Gm971 antibody
  • HECW2 antibody
  • mKIAA1301 antibody
  • Nedl2 antibody

Protein level used designations for HECW2

E3 ubiquitin-protein ligase HECW2 , HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 , E3 ubiquitin-protein ligase HECW2-like , e3 ubiquitin-protein ligase HECW2-like , HECT, C2 and WW domain-containing protein 2 , NEDD4-like E3 ubiquitin-protein ligase 2 , NEDD4-related E3 ubiquitin ligase NEDL2

GENE ID SPECIES
316395 Rattus norvegicus
424050 Gallus gallus
459844 Pan troglodytes
531691 Bos taurus
100055015 Equus caballus
100331355 Danio rerio
100411186 Callithrix jacchus
100444189 Pongo abelii
100469664 Ailuropoda melanoleuca
100560989 Anolis carolinensis
100602550 Nomascus leucogenys
57520 Homo sapiens
329152 Mus musculus
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