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anti-HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) Antibodies

HUWE1 encodes a member of the HECT E3 ubiquitin ligase family. Additionally we are shipping HUWE1 Kits (6) and HUWE1 Proteins (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HUWE1 59026 Q7TMY8
HUWE1 10075 Q7Z6Z7
HUWE1 501546  
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Top anti-HUWE1 Antibodies at antibodies-online.com

Showing 10 out of 54 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IF, WB Immunocytochemistry of ARF-BP1 in Daudi cells with AP30078PU-N ARF-BP1 antibody at 5 μg/ml. Immunofluorescence of ARF-BP1 in Daudi cells with AP30078PU-N ARF-BP1 antibody at 20 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), IP, PLA, WB Detection of Human Ureb1/Lasu1 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (5, 15 and 50 mcg for WB, 1 mg for IP, 1/4 of IP loaded) from 293T cells. Antibodies: ABIN152075 used at 1 mcg/ml for WB (A and B) and at 3 mcg/mg lysate for IP (B). Ureb1/Lasu1 was less efficiently immunoprecipitated by another Ureb1/Lasu1 antibody, which is an affinity purified rabbit antibody to a downstream epitope from Ureb1/Lasu1. Detection: Chemiluminescence with an exposure time of 10 seconds. Immunohistochemistry-Paraffin: HUWE1 Antibody [ABIN152075] - FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit antiLasu1/Ureb1 used at a dilution of 1:1,000 (1ug/ml). Detection: DAB Counterstain: IHC Hematoxylin (blue). 100 μL Log in to see 5 to 7 Days
$486.94
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (36.45 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Rabbit Un-conjugated IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IHC (p), WB Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with HUWE1 antibody ABIN213933 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Human Heart (formalin-fixed, paraffin-embedded) stained with HUWE1 antibody ABIN213933 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Goat Un-conjugated ELISA   0.1 mg Log in to see 5 to 7 Days
$317.63
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, WB Immunocytochemistry/Immunofluorescence: HUWE1 Antibody [NBP1-76795] - Daudi cells with HUWE1 antibody at 5 ug/ml. Western Blot: HUWE1 Antibody [NBP1-76795] - Daudi cell lysate with HUWE1 antibody at 1 ug/ml. 0.1 mg Log in to see 6 to 9 Days
$447.56
Details
Human Rabbit Un-conjugated ICC, ELISA, WB   100 μg Log in to see 15 to 19 Days
$466.62
Details
Human Goat Un-conjugated ELISA   0.1 mg Log in to see 2 to 3 Days
$446.88
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunocytochemistry/Immunofluorescence: HUWE1 Antibody [NBP1-83127] Staining of human cell line U-251MG shows positivity in nucleus but not nucleoli & cytoplasm. Immunohistochemistry-Paraffin: HUWE1 Antibody [NBP1-83127] - Staining of human testis shows strong nuclear and cytoplasmic positivity in cells of seminiferus ducts. 0.1 mL Log in to see 8 to 11 Days
$439.69
Details

HUWE1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-HUWE1 Antibodies

  1. Human Polyclonal HUWE1 Primary Antibody for ICC, IF - ABIN152075 : Hall, Kow, Nevis, Lu, Luce, Zhong, Cook: Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage. in Molecular biology of the cell 2007 (PubMed)
    Show all 13 references for ABIN152075

  2. Human Polyclonal HUWE1 Primary Antibody for ICC, ELISA - ABIN1001821 : Gallagher, Kefford, Rizos: The ARF tumour suppressor. in The international journal of biochemistry & cell biology 2006 (PubMed)
    Show all 4 references for ABIN1001821

  3. Human Polyclonal HUWE1 Primary Antibody for EIA, IF - ABIN499331 : Zhong, Gao, Du, Wang: Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. in Cell 2005 (PubMed)
    Show all 3 references for ABIN499331

  4. Human Polyclonal HUWE1 Primary Antibody for ELISA, WB - ABIN564354 : Katsogiannou, Andrieu, Baylot, Baudot, Dusetti, Gayet, Finetti, Garrido, Birnbaum, Bertucci, Brun, Rocchi: The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. in Molecular & cellular proteomics : MCP 2014 (PubMed)

  5. Human Polyclonal HUWE1 Primary Antibody for ELISA - ABIN4222056 : Stankiewicz, Livingstone, Mohseni, Mosser: Regulation of heat-induced apoptosis by Mcl-1 degradation and its inhibition by Hsp70. in Cell death and differentiation 2009 (PubMed)

More Antibodies against HUWE1 Interaction Partners

Mouse (Murine) HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) interaction partners

  1. this study shows that the E3-ubiquitin ligase Huwe1 (HECT, UBA, and WWE domain-containing 1) is required for proliferating stem cells of the adult mouse hippocampus to return to quiescence.

  2. TNF (show TNF Antibodies) activates Mule by inducing the dissociation of Mule from its inhibitor ARF (show CDKN2A Antibodies). Inhibition of Mule phosphorylation by silencing Syk (show SYK Antibodies) prevents this, thereby inhibiting Mule E3 ligase activity and TNF (show TNF Antibodies)-induced JNK (show MAPK8 Antibodies) activation and cell death.

  3. expression level of miR (show MLXIP Antibodies)-98, which can regulate Caspase-3 (show CASP3 Antibodies), was significantly decreased. Huwe1, the host gene of miR (show MLXIP Antibodies)-98, was positively associated with miR (show MLXIP Antibodies)-98 expression after Silica NP exposure

  4. Thus, modulating the levels of both Huwe1 and USP10 (show USP10 Antibodies) appears to fine-tune the requisite degradation of TBP (show TBP Antibodies) during myogenesis.

  5. Results show that ARF-BP1 was expressed at high levels in B-cell lymphoma cell lines and by regulating MYC and p53 transcriptional activity, ARF-BP1 is a critical determinant of the proliferation of B cell lymphomas.

  6. The dynamic balance between MYC and p53 required for normal B cell maturation and function is finely tuned and critically dependent on the activities of ARF-BP1.

  7. data demonstrate in vivo that Mule suppresses Ras-mediated tumorigenesis by preventing an accumulation of c-Myc (show MYC Antibodies)/Miz1 (show PIAS2 Antibodies) complexes that mediates p21 (show D4S234E Antibodies) and p15 (show CDKN2B Antibodies) down-regulation

  8. an important role of ARF-BP1 in maintaining beta-cell homeostasis in aging mice and reveal that the stability of p53 is critically regulated by ARF-BP1 in vivo.

  9. Mule regulates the ATM (show ATM Antibodies)-p53 (show TP53 Antibodies) axis to maintain B cell homeostasis under both steady-state and stress conditions.

  10. Mitochondrion-dependent N-terminal processing of outer membrane Mcl-1 protein removes an essential Mule/Lasu1 protein-binding site.

Human HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) interaction partners

  1. We identified a HUWE1 mutation in an affected male with Juberg-Marsidi and Brooks syndromes from the original family reported by Juberg and Marsidi; it is evident the syndrome does not result from a mutation in ATRX as reported in the literature. Additionally, the data indicated that Juberg-Marsidi syndrome and Brooks syndromes are allelic having the same HUWE1 mutation.

  2. Results reveal a pathway controlled by ATM, SIRT6, and SNF2H to block HUWE1, which stabilizes H2AX and induces its incorporation into chromatin only when cells are damaged.

  3. miR-542-5p plays a critical role in the proliferation of osteosarcoma and targets HUWE1.

  4. TNF (show TNF Antibodies) activates Mule by inducing the dissociation of Mule from its inhibitor ARF (show CDKN2A Antibodies). Inhibition of Mule phosphorylation by silencing Syk (show SYK Antibodies) prevents this, thereby inhibiting Mule E3 ligase activity and TNF (show TNF Antibodies)-induced JNK (show MAPK8 Antibodies) activation and cell death.

  5. HUWE1 and NEDD4-1 (show NEDD4 Antibodies) are two E3 ligases that are fundamental enzymes in the post-translational regulation of ABCG1 (show ABCG1 Antibodies) and ABCG4 (show ABCG4 Antibodies) protein levels and cellular cholesterol export activity

  6. Results show that ARF-BP1 was expressed at high levels in B-cell lymphoma cell lines and by regulating MYC and p53 transcriptional activity, ARF-BP1 is a critical determinant of the proliferation of B cell lymphomas.

  7. Our findings highlight the importance of microduplications at Xp11.22 to ID, even in sporadic cases, and reveal new clinical and molecular insight into HUWE1 copy number gains.

  8. we show that HUWE1 stimulates human lung cancer cell invasion through regulating TIAM1 (show TIAM1 Antibodies) stability. Finally, we demonstrate that HUWE1 and TIAM1 (show TIAM1 Antibodies) protein levels are inversely correlated in human lung carcinomas

  9. Inhibition of HUWE1 stabilizes MIZ1 (show ZBTB17 Antibodies) and induces global accumulation of MIZ1 (show ZBTB17 Antibodies) on MYC (show MYC Antibodies)-bound target genes.

  10. analysis of ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4 (show DDIT4 Antibodies)) by the E3 ligase HUWE1

HUWE1 Antigen Profile

Protein Summary

This gene encodes a member of the HECT E3 ubiquitin ligase family. The HECT domain lies in the C-terminus and contains the active-site cysteine which forms an intermediate ubiquitin-thioester bond. E3 family members are divided into three subfamilies based on their protein-protein interaction domains\; this gene encodes a member of the SI(ngle)-HECT E3 subfamily. In lung, breast, and colorectal carcinomas, this gene is highly expressed. Mutations in this gene has been found in 3 unrelated families with X-linked syndromic mental retardation, Turner type.

Gene names and symbols associated with HUWE1

  • HECT, UBA and WWE domain containing 1 (Huwe1) antibody
  • HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (HUWE1) antibody
  • HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (Huwe1) antibody
  • 5430439H10Rik antibody
  • ARF-BP1 antibody
  • AU041296 antibody
  • C80292 antibody
  • C430014N20Rik antibody
  • Gm1718 antibody
  • HECTH9 antibody
  • HSPC272 antibody
  • Ib772 antibody
  • LASU1 antibody
  • MULE antibody
  • URE-B1 antibody
  • UREB1 antibody

Protein level used designations for HUWE1

E3 ubiquitin-protein ligase HUWE1 , E3Histone , HECT, UBA and WWE domain-containing protein 1 , Mcl-1 ubiquitin ligase , URE-B1 , URE-binding protein 1 , upstream regulatory element binding protein 1 , upstream regulatory element-binding protein 1 , ARF-binding protein 1 , BJ-HCC-24 tumor antigen , HECT domain protein LASU1 , Mcl-1 ubiquitin ligase E3 , homologous to E6AP carboxyl terminus homologous protein 9 , large structure of UREB1

GENE ID SPECIES
59026 Mus musculus
10075 Homo sapiens
501546 Rattus norvegicus
Selected quality suppliers for anti-HUWE1 (HUWE1) Antibodies
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