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HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase Proteins (HUWE1)

HUWE1 encodes a member of the HECT E3 ubiquitin ligase family. Additionally we are shipping HUWE1 Antibodies (49) and HUWE1 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse HUWE1 HUWE1 59026 Q7TMY8
HUWE1 10075 Q7Z6Z7
HUWE1 501546  
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Top HUWE1 Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,865.50
Details

HUWE1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Rat (Rattus)

More Proteins for HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) Interaction Partners

Mouse (Murine) HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) interaction partners

  1. this study shows that the E3-ubiquitin ligase Huwe1 (HECT, UBA, and WWE domain-containing 1) is required for proliferating stem cells of the adult mouse hippocampus to return to quiescence.

  2. TNF (show TNF Proteins) activates Mule by inducing the dissociation of Mule from its inhibitor ARF. Inhibition of Mule phosphorylation by silencing Syk (show SYK Proteins) prevents this, thereby inhibiting Mule E3 ligase activity and TNF (show TNF Proteins)-induced JNK (show MAPK8 Proteins) activation and cell death.

  3. expression level of miR (show MLXIP Proteins)-98, which can regulate Caspase-3 (show CASP3 Proteins), was significantly decreased. Huwe1, the host gene of miR (show MLXIP Proteins)-98, was positively associated with miR (show MLXIP Proteins)-98 expression after Silica NP exposure

  4. Thus, modulating the levels of both Huwe1 and USP10 (show USP10 Proteins) appears to fine-tune the requisite degradation of TBP (show TBP Proteins) during myogenesis.

  5. Results show that ARF-BP1 was expressed at high levels in B-cell lymphoma cell lines and by regulating MYC and p53 transcriptional activity, ARF-BP1 is a critical determinant of the proliferation of B cell lymphomas.

  6. The dynamic balance between MYC and p53 required for normal B cell maturation and function is finely tuned and critically dependent on the activities of ARF-BP1.

  7. data demonstrate in vivo that Mule suppresses Ras-mediated tumorigenesis by preventing an accumulation of c-Myc (show MYC Proteins)/Miz1 (show PIAS2 Proteins) complexes that mediates p21 and p15 (show CDKN2B Proteins) down-regulation

  8. an important role of ARF-BP1 in maintaining beta-cell homeostasis in aging mice and reveal that the stability of p53 is critically regulated by ARF-BP1 in vivo.

  9. Mule regulates the ATM (show ATM Proteins)-p53 (show TP53 Proteins) axis to maintain B cell homeostasis under both steady-state and stress conditions.

  10. Mitochondrion-dependent N-terminal processing of outer membrane Mcl-1 protein removes an essential Mule/Lasu1 protein-binding site.

Human HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) interaction partners

  1. miR-542-5p plays a critical role in the proliferation of osteosarcoma and targets HUWE1.

  2. TNF (show TNF Proteins) activates Mule by inducing the dissociation of Mule from its inhibitor ARF. Inhibition of Mule phosphorylation by silencing Syk (show SYK Proteins) prevents this, thereby inhibiting Mule E3 ligase activity and TNF (show TNF Proteins)-induced JNK (show MAPK8 Proteins) activation and cell death.

  3. HUWE1 and NEDD4-1 (show NEDD4 Proteins) are two E3 ligases that are fundamental enzymes in the post-translational regulation of ABCG1 (show ABCG1 Proteins) and ABCG4 (show ABCG4 Proteins) protein levels and cellular cholesterol export activity

  4. Results show that ARF-BP1 was expressed at high levels in B-cell lymphoma cell lines and by regulating MYC and p53 transcriptional activity, ARF-BP1 is a critical determinant of the proliferation of B cell lymphomas.

  5. Our findings highlight the importance of microduplications at Xp11.22 to ID, even in sporadic cases, and reveal new clinical and molecular insight into HUWE1 copy number gains.

  6. we show that HUWE1 stimulates human lung cancer cell invasion through regulating TIAM1 (show TIAM1 Proteins) stability. Finally, we demonstrate that HUWE1 and TIAM1 (show TIAM1 Proteins) protein levels are inversely correlated in human lung carcinomas

  7. Inhibition of HUWE1 stabilizes MIZ1 (show ZBTB17 Proteins) and induces global accumulation of MIZ1 (show ZBTB17 Proteins) on MYC (show MYC Proteins)-bound target genes.

  8. analysis of ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4 (show DDIT4 Proteins)) by the E3 ligase HUWE1

  9. Results demonstrate that HUWE1 is a novel player involved in regulating ERK1/2 signal transmission through the Shoc2 (show SHOC2 Proteins) scaffold complex.

  10. Ubiquitin ligase HUWE1 regulates axon branching through the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway in a Drosophila model for intellectual disability.

HUWE1 Protein Profile

Protein Summary

This gene encodes a member of the HECT E3 ubiquitin ligase family. The HECT domain lies in the C-terminus and contains the active-site cysteine which forms an intermediate ubiquitin-thioester bond. E3 family members are divided into three subfamilies based on their protein-protein interaction domains\; this gene encodes a member of the SI(ngle)-HECT E3 subfamily. In lung, breast, and colorectal carcinomas, this gene is highly expressed. Mutations in this gene has been found in 3 unrelated families with X-linked syndromic mental retardation, Turner type.

Gene names and symbols associated with HUWE1

  • HECT, UBA and WWE domain containing 1 (Huwe1)
  • HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (HUWE1)
  • HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (Huwe1)
  • 5430439H10Rik protein
  • ARF-BP1 protein
  • AU041296 protein
  • C80292 protein
  • C430014N20Rik protein
  • Gm1718 protein
  • HECTH9 protein
  • HSPC272 protein
  • Ib772 protein
  • LASU1 protein
  • MULE protein
  • URE-B1 protein
  • UREB1 protein

Protein level used designations for HUWE1

E3 ubiquitin-protein ligase HUWE1 , E3Histone , HECT, UBA and WWE domain-containing protein 1 , Mcl-1 ubiquitin ligase , URE-B1 , URE-binding protein 1 , upstream regulatory element binding protein 1 , upstream regulatory element-binding protein 1 , ARF-binding protein 1 , BJ-HCC-24 tumor antigen , HECT domain protein LASU1 , Mcl-1 ubiquitin ligase E3 , homologous to E6AP carboxyl terminus homologous protein 9 , large structure of UREB1

GENE ID SPECIES
59026 Mus musculus
10075 Homo sapiens
501546 Rattus norvegicus
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