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E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Additionally we are shipping HACE1 Kits (10) and HACE1 Proteins (4) and many more products for this protein.
Showing 10 out of 27 products:
Cow (Bovine) Polyclonal HACE1 Primary Antibody for WB - ABIN2774769
Zhang, Anglesio, OSullivan, Zhang, Yang, Sarao, Mai, Cronin, Hara, Melnyk, Li, Wada, Liu, Farrar, Arceci, Sorensen, Penninger: The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers. in Nature medicine 2007
Mechanistic studies showed that HACE1 exerts its inhibitory role on virus-induced signaling by disrupting the MAVS (show MAVS Antibodies)-TRAF3 (show TRAF3 Antibodies) complex.
HACE1 can act as a haploinsufficient tumor suppressor gene in most B-cell lymphomas and can be downregulated by deacetylation of its promoter region chromatin
Hepatocellular carcinoma patients with low HACE1 expression levels exhibited poorer overall survival and HACE1 was found to be an independent prognostic factor for survival.
HACE1 as a specific E3 ligase that polyubiquitinates YB-1 through non-canonical K27 linked ubiquitin chains.
Biallelic loss-of-function mutations in HACE1 are associated with an autosomal recessive neurodevelopmental syndrome.
supports a critical role for HACE1 in breast cancer progression and identifies patients that may benefit from Rac (show AKT1 Antibodies)-targeted therapies
contrary to previous report, overexpression of HACE1 by transduction of recombinant protein did not affect proliferation or survival of NKTCL cell lines. We therefore conclude that HACE1 is not directly involved in NKTCL pathophysiology
HACE1-OPTN (show OPTN Antibodies) axis synergistically suppresses growth and tumorigenicity of lung cancer cells.
Ubiquitylation and activation of RAB11a (show RAB11A Antibodies) is promoted by a beta2 adrenergic receptor (show ADRB2 Antibodies)-HACE1 complex.
HACE1 reduces oxidative stress and mutant Huntingtin (show HTT Antibodies) toxicity by promoting the NRF2 (show GABPA Antibodies) response.
Increased reactive oxygen species (ROS (show ROS1 Antibodies)) production due to Hace1 loss leads to glutamine (show GFPT1 Antibodies) addiction as a mechanism to cope with increased ROS (show ROS1 Antibodies)-induced oxidative stress.
Data indicate that HECT E3 ubiquitin ligase (show MUL1 Antibodies) HACE1 deficiency accelerates pressure overload-induced heart failure.
Hace1 controls ROS (show ROS1 Antibodies) generation of vertebrate Rac1-dependent NADPH oxidase (show NOX1 Antibodies) complexes.
E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB (By similarity).
HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
, E3 ubiquitin-protein ligase HACE1
, HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1
, E3 ubiquitin-protein ligase HACE1-like
, e3 ubiquitin-protein ligase HACE1-like